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- W4322713590 abstract "The work that has been carried out describes for the first time the hereditary caused breast cancer cases in Gomel region of Belarus, having defined a spectrum and frequencies of the most significant genetic factors underlying the given pathology. After the molecular-genetic testing of 667 primary breast cancer cases it was shown that out of eight BRCA1/2 gene mutations that are widely spread in Eastern Europe there are only five ones in Gomel region of Belarus with various frequencies - 185delAG, 300T>G, 4153delA, 5382insC and 6174delT. The 2274insA, 3819del5 and 3875del4 mutations were not found in the studied group. The 5382insC mutation was found to be the predominant one, which has made 80 % of all the detected mutations. Total mutation frequency in nonselective sampling taking into consideration the standardized indicators of age structure has made 7,9 %. It was found out, that family anamnesis is the most significant criterion from the point of view of probability estimation of BRCA1/2 mutations in genotype. In the united subgroup of patients with any of the basic signs of family cancer and their combinations, the share of mutations has made 24,4 %." @default.
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- W4322713590 date "2009-12-28" @default.
- W4322713590 modified "2023-10-04" @default.
- W4322713590 title "ESTIMATION OF GENETIC PREDISPOSITION TO BREAST CANCER BY TESTING OF MOST FREQUENT MUTATIONS OF BRCA1 AND BRCA2 GENES IN GROUP OF PATIENTS FROM GOMEL REGION OF BELARUS" @default.
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- W4322713590 doi "https://doi.org/10.51523/2708-6011.2009-6-4-20" @default.
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