FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322719421> ?p ?o ?g. }

• W4322719421 endingPage "1754" @default.
• W4322719421 startingPage "1745" @default.
• W4322719421 abstract "Abstract Background and purpose Elevated plasma concentrations of neural cell adhesion molecule 1 (NCAM1) and p75 neurotrophin receptor (p75) in patients with peripheral neuropathy have been reported. This study aimed to determine the specificity of plasma concentration elevation of either NCAM1 or p75 in a subtype of Charcot–Marie–Tooth disease (CMT) and its correlation with pathologic nerve status and disease severity. Methods Blood samples were collected from 138 patients with inherited peripheral neuropathy and 51 healthy controls. Disease severity was measured using Charcot–Marie–Tooth Neuropathy Score version 2 (CMTNSv2), and plasma concentrations of NCAM1 and p75 were analyzed by enzyme‐linked immunosorbent assay. Eight sural nerves from CMT patients were examined to determine the relation of histopathology and plasma NCAM1 levels. Results Plasma concentration of NCAM1, but not p75, was specifically increased in demyelinating subtypes of CMT (median = 7100 pg/mL, p < 0.001), including CMT1A, but not in axonal subtype (5964 pg/mL, p > 0.05), compared to the control (3859 pg/mL). CMT1A patients with mild or moderate severity (CMTNSv2 < 20) showed higher levels of plasma NCAM1 than healthy controls. Immunofluorescent NCAM1 staining for the sural nerves of CMT patients showed that NCAM1‐positive onion bulb cells and possible demyelinating Schwann cells might be associated with the specific increase of plasma NCAM1 in demyelinating CMT. Conclusions The plasma NCAM1 levels in demyelinating CMT might be a surrogate biomarker reflecting pathological Schwann cell status and disease progression." @default.
• W4322719421 created "2023-03-03" @default.
• W4322719421 creator A5000281929 @default.
• W4322719421 creator A5013694438 @default.
• W4322719421 creator A5014130986 @default.
• W4322719421 creator A5032590176 @default.
• W4322719421 creator A5045067575 @default.
• W4322719421 creator A5065413579 @default.
• W4322719421 creator A5073638057 @default.
• W4322719421 creator A5081630671 @default.
• W4322719421 creator A5087195085 @default.
• W4322719421 date "2023-03-15" @default.
• W4322719421 modified "2023-10-02" @default.
• W4322719421 title "Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating <scp>Charcot–Marie–Tooth</scp> disease" @default.
• W4322719421 cites W1965932992 @default.
• W4322719421 cites W2026396965 @default.
• W4322719421 cites W2037297256 @default.
• W4322719421 cites W2050272130 @default.
• W4322719421 cites W2054687813 @default.
• W4322719421 cites W2059771026 @default.
• W4322719421 cites W2062821199 @default.
• W4322719421 cites W2086910505 @default.
• W4322719421 cites W2114285561 @default.
• W4322719421 cites W2121807254 @default.
• W4322719421 cites W2143866689 @default.
• W4322719421 cites W2550635752 @default.
• W4322719421 cites W2599903881 @default.
• W4322719421 cites W2783746308 @default.
• W4322719421 cites W2886211838 @default.
• W4322719421 cites W2899327057 @default.
• W4322719421 cites W2933505114 @default.
• W4322719421 cites W2955450231 @default.
• W4322719421 cites W2995102752 @default.
• W4322719421 cites W2998605915 @default.
• W4322719421 cites W3114441989 @default.
• W4322719421 cites W3196297321 @default.
• W4322719421 cites W4210875960 @default.
• W4322719421 doi "https://doi.org/10.1111/ene.15763" @default.
• W4322719421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36856547" @default.
• W4322719421 hasPublicationYear "2023" @default.
• W4322719421 type Work @default.
• W4322719421 citedByCount "0" @default.
• W4322719421 crossrefType "journal-article" @default.
• W4322719421 hasAuthorship W4322719421A5000281929 @default.
• W4322719421 hasAuthorship W4322719421A5013694438 @default.
• W4322719421 hasAuthorship W4322719421A5014130986 @default.
• W4322719421 hasAuthorship W4322719421A5032590176 @default.
• W4322719421 hasAuthorship W4322719421A5045067575 @default.
• W4322719421 hasAuthorship W4322719421A5065413579 @default.
• W4322719421 hasAuthorship W4322719421A5073638057 @default.
• W4322719421 hasAuthorship W4322719421A5081630671 @default.
• W4322719421 hasAuthorship W4322719421A5087195085 @default.
• W4322719421 hasConcept C122871604 @default.
• W4322719421 hasConcept C134018914 @default.
• W4322719421 hasConcept C142724271 @default.
• W4322719421 hasConcept C1491633281 @default.
• W4322719421 hasConcept C185592680 @default.
• W4322719421 hasConcept C203014093 @default.
• W4322719421 hasConcept C2777004073 @default.
• W4322719421 hasConcept C2779901536 @default.
• W4322719421 hasConcept C2780640218 @default.
• W4322719421 hasConcept C2780923182 @default.
• W4322719421 hasConcept C2781197716 @default.
• W4322719421 hasConcept C55493867 @default.
• W4322719421 hasConcept C555293320 @default.
• W4322719421 hasConcept C71924100 @default.
• W4322719421 hasConcept C85789140 @default.
• W4322719421 hasConceptScore W4322719421C122871604 @default.
• W4322719421 hasConceptScore W4322719421C134018914 @default.
• W4322719421 hasConceptScore W4322719421C142724271 @default.
• W4322719421 hasConceptScore W4322719421C1491633281 @default.
• W4322719421 hasConceptScore W4322719421C185592680 @default.
• W4322719421 hasConceptScore W4322719421C203014093 @default.
• W4322719421 hasConceptScore W4322719421C2777004073 @default.
• W4322719421 hasConceptScore W4322719421C2779901536 @default.
• W4322719421 hasConceptScore W4322719421C2780640218 @default.
• W4322719421 hasConceptScore W4322719421C2780923182 @default.
• W4322719421 hasConceptScore W4322719421C2781197716 @default.
• W4322719421 hasConceptScore W4322719421C55493867 @default.
• W4322719421 hasConceptScore W4322719421C555293320 @default.
• W4322719421 hasConceptScore W4322719421C71924100 @default.
• W4322719421 hasConceptScore W4322719421C85789140 @default.
• W4322719421 hasFunder F4320322111 @default.
• W4322719421 hasFunder F4320322120 @default.
• W4322719421 hasIssue "6" @default.
• W4322719421 hasLocation W43227194211 @default.
• W4322719421 hasLocation W43227194212 @default.
• W4322719421 hasOpenAccess W4322719421 @default.
• W4322719421 hasPrimaryLocation W43227194211 @default.
• W4322719421 hasRelatedWork W1992868186 @default.
• W4322719421 hasRelatedWork W1999295072 @default.
• W4322719421 hasRelatedWork W2050272130 @default.
• W4322719421 hasRelatedWork W2140366096 @default.
• W4322719421 hasRelatedWork W2339005134 @default.
• W4322719421 hasRelatedWork W2357026944 @default.
• W4322719421 hasRelatedWork W2373096389 @default.
• W4322719421 hasRelatedWork W2394330061 @default.
• W4322719421 hasRelatedWork W2617222556 @default.

• next