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- W4322719571 abstract "A mild strategy for Co(III)-catalyzed C(sp2)-H cyanation of indoles was developed by using NCBLD as an electrophilic cyanation reagent and 1-butyl-3-acetylimidazole ditrifluoromethylsulfonimide ([BAIM]NTf2) as an environmentally friendly and recyclable solvent, and a series of 2-cyano products were obtained at room temperature. Adopting this strategy, the unnatural nucleotide fragment precursor of Remdesivir, which was a drug for COVID-19, was synthesized through cyano transformation, further proving the practicability of this cyanation method." @default.
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- W4322719571 date "2023-03-01" @default.
- W4322719571 modified "2023-09-27" @default.
- W4322719571 title "<i>N</i>-Cyano-2,2′-biphenyldicarboimide as a Cyanation Reagent for Co(III)-Catalyzed C–H Cyanation of Indoles in Ionic Liquids" @default.
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- W4322719571 doi "https://doi.org/10.1021/acs.orglett.3c00164" @default.
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