FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322719962> ?p ?o ?g. }

• W4322719962 abstract "Objective Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy. An increasingly identified subset of patients with TLE consists of those who show bilaterally independent temporal lobe seizures. The purpose of this study was to leverage network neuroscience to better understand the interictal whole brain network of bilateral TLE (BiTLE). Methods In this study, using a multicenter resting state functional magnetic resonance imaging (rs-fMRI) data set, we constructed whole-brain functional networks of 19 patients with BiTLE, and compared them to those of 75 patients with unilateral TLE (UTLE). We quantified resting-state, whole-brain topological properties using metrics derived from network theory, including clustering coefficient, global efficiency, participation coefficient, and modularity. For each metric, we computed an average across all brain regions, and iterated this process across network densities. Curves of network density vs each network metric were compared between groups. Finally, we derived a combined metric, which we term the “integration-segregation axis,” by combining whole-brain average clustering coefficient and global efficiency curves, and applying principal component analysis (PCA)–based dimensionality reduction. Results Compared to UTLE, BiTLE had decreased global efficiency (p = .031), and decreased whole brain average participation coefficient across a range of network densities (p = .019). Modularity maximization yielded a larger number of smaller communities in BiTLE than in UTLE (p = .020). Differences in network properties separate BiTLE and UTLE along the integration-segregation axis, with regions within the axis having a specificity of up to 0.87 for BiTLE. Along the integration-segregation axis, UTLE patients with poor surgical outcomes were distributed in the same regions as BiTLE, and network metrics confirmed similar patterns of increased segregation in both BiTLE and poor outcome UTLE. Significance Increased interictal whole-brain network segregation, as measured by rs-fMRI, is specific to BiTLE, as well as poor surgical outcome UTLE, and may assist in non-invasively identifying this patient population prior to intracranial electroencephalography or device implantation." @default.
• W4322719962 created "2023-03-03" @default.
• W4322719962 creator A5006851856 @default.
• W4322719962 creator A5007603388 @default.
• W4322719962 creator A5025795521 @default.
• W4322719962 creator A5037974362 @default.
• W4322719962 creator A5040928549 @default.
• W4322719962 creator A5047157013 @default.
• W4322719962 creator A5051033644 @default.
• W4322719962 creator A5057823907 @default.
• W4322719962 creator A5067569321 @default.
• W4322719962 creator A5071227075 @default.
• W4322719962 creator A5075448829 @default.
• W4322719962 creator A5079120203 @default.
• W4322719962 date "2023-03-20" @default.
• W4322719962 modified "2023-09-27" @default.
• W4322719962 title "Resting state functional connectivity demonstrates increased segregation in bilateral temporal lobe epilepsy" @default.
• W4322719962 cites W1546583880 @default.
• W4322719962 cites W1920448680 @default.
• W4322719962 cites W1973855259 @default.
• W4322719962 cites W1991513523 @default.
• W4322719962 cites W2017987256 @default.
• W4322719962 cites W2024066705 @default.
• W4322719962 cites W2030848759 @default.
• W4322719962 cites W2079207152 @default.
• W4322719962 cites W2108056153 @default.
• W4322719962 cites W2117523955 @default.
• W4322719962 cites W2121709831 @default.
• W4322719962 cites W2128616678 @default.
• W4322719962 cites W2133858753 @default.
• W4322719962 cites W2138790588 @default.
• W4322719962 cites W2167822639 @default.
• W4322719962 cites W2317495993 @default.
• W4322719962 cites W2402346616 @default.
• W4322719962 cites W2731922686 @default.
• W4322719962 cites W2759409764 @default.
• W4322719962 cites W2894585821 @default.
• W4322719962 cites W2944341921 @default.
• W4322719962 cites W2950086191 @default.
• W4322719962 cites W2954856236 @default.
• W4322719962 cites W2972603548 @default.
• W4322719962 cites W3008793891 @default.
• W4322719962 cites W3081345152 @default.
• W4322719962 cites W3083017933 @default.
• W4322719962 cites W3163968030 @default.
• W4322719962 cites W3207722339 @default.
• W4322719962 cites W322832166 @default.
• W4322719962 cites W4210685811 @default.
• W4322719962 cites W4225678479 @default.
• W4322719962 cites W4280546425 @default.
• W4322719962 cites W4295750005 @default.
• W4322719962 cites W586899634 @default.
• W4322719962 doi "https://doi.org/10.1111/epi.17565" @default.
• W4322719962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36855286" @default.
• W4322719962 hasPublicationYear "2023" @default.
• W4322719962 type Work @default.
• W4322719962 citedByCount "4" @default.
• W4322719962 countsByYear W43227199622023 @default.
• W4322719962 crossrefType "journal-article" @default.
• W4322719962 hasAuthorship W4322719962A5006851856 @default.
• W4322719962 hasAuthorship W4322719962A5007603388 @default.
• W4322719962 hasAuthorship W4322719962A5025795521 @default.
• W4322719962 hasAuthorship W4322719962A5037974362 @default.
• W4322719962 hasAuthorship W4322719962A5040928549 @default.
• W4322719962 hasAuthorship W4322719962A5047157013 @default.
• W4322719962 hasAuthorship W4322719962A5051033644 @default.
• W4322719962 hasAuthorship W4322719962A5057823907 @default.
• W4322719962 hasAuthorship W4322719962A5067569321 @default.
• W4322719962 hasAuthorship W4322719962A5071227075 @default.
• W4322719962 hasAuthorship W4322719962A5075448829 @default.
• W4322719962 hasAuthorship W4322719962A5079120203 @default.
• W4322719962 hasBestOaLocation W43227199622 @default.
• W4322719962 hasConcept C153180895 @default.
• W4322719962 hasConcept C154945302 @default.
• W4322719962 hasConcept C15744967 @default.
• W4322719962 hasConcept C162324750 @default.
• W4322719962 hasConcept C169760540 @default.
• W4322719962 hasConcept C176217482 @default.
• W4322719962 hasConcept C17755696 @default.
• W4322719962 hasConcept C21547014 @default.
• W4322719962 hasConcept C22047676 @default.
• W4322719962 hasConcept C2778186239 @default.
• W4322719962 hasConcept C2779478453 @default.
• W4322719962 hasConcept C2781099131 @default.
• W4322719962 hasConcept C41008148 @default.
• W4322719962 hasConcept C54355233 @default.
• W4322719962 hasConcept C66324658 @default.
• W4322719962 hasConcept C73555534 @default.
• W4322719962 hasConcept C86803240 @default.
• W4322719962 hasConceptScore W4322719962C153180895 @default.
• W4322719962 hasConceptScore W4322719962C154945302 @default.
• W4322719962 hasConceptScore W4322719962C15744967 @default.
• W4322719962 hasConceptScore W4322719962C162324750 @default.
• W4322719962 hasConceptScore W4322719962C169760540 @default.
• W4322719962 hasConceptScore W4322719962C176217482 @default.
• W4322719962 hasConceptScore W4322719962C17755696 @default.
• W4322719962 hasConceptScore W4322719962C21547014 @default.
• W4322719962 hasConceptScore W4322719962C22047676 @default.
• W4322719962 hasConceptScore W4322719962C2778186239 @default.
• W4322719962 hasConceptScore W4322719962C2779478453 @default.

• next