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• W4322724508 abstract "The persistent activation of neutrophils and the excessive neutrophil extracellular traps (NETs) formation are the main determinants of pancreatic tissue injury and systemic inflammatory response in acute pancreatitis (AP). Thus, inhibiting the release of NETs can effectively prevent the aggravation of AP. Here, our study showed that the pore-forming protein gasdermin D (GSDMD) was activity in neutrophils of AP mice and patients and played the vital role in NETs formation. Through the application of GSDMD inhibitor or the construction of neutrophil GSDMD specific knockout mice, it was found in vivo and in vitro that inhibition of GSDMD could block the NETs formation, reduce pancreatic injury, systemic inflammatory reaction and organ failure in AP mice. To sum up, our findings confirmed that neutrophil GSDMD was the therapeutic target for improving the occurrence and development of AP." @default.
• W4322724508 created "2023-03-03" @default.
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• W4322724508 date "2023-04-01" @default.
• W4322724508 modified "2023-10-18" @default.
• W4322724508 title "Inhibition of Gasdermin D blocks the formation of NETs and protects acute pancreatitis in mice" @default.
• W4322724508 cites W1565772479 @default.
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• W4322724508 doi "https://doi.org/10.1016/j.bbrc.2023.02.082" @default.
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