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- W4322731833 abstract "We present a novel design of elastic micropillars for tissue self-assembly in engineered heart tissue (EHT) platforms. The innovative tapered profile confines reproducibly the tissue position along the main micropillar axis, increasing the accuracy of tissue contraction force measurement. Polydimethylsiloxane-based pillars were designed and fabricated by wafer-level molding in an hourglass shape, with symmetric tapering producing a restriction for tissue movement in the middle of the pillars’ length. Confinement efficacy of the new geometry was validated by comparing the tissue performance in straight versus tapered (75° or 80° tapering angle) micropillars. While in all three cases compact tissues formed successfully, for both tapered designs the functionality assays evidenced yield increase from 15% to 100%, higher spatial tissue confinement, and correspondingly higher accuracy and smaller dispersion in measurements of tissue contraction force." @default.
- W4322731833 created "2023-03-03" @default.
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- W4322731833 date "2023-01-15" @default.
- W4322731833 modified "2023-09-24" @default.
- W4322731833 title "Highly Reproducible Tissue Positioning with Tapered Pillar Design in Engineered Heart Tissue Platforms" @default.
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- W4322731833 doi "https://doi.org/10.1109/mems49605.2023.10052166" @default.
- W4322731833 hasPublicationYear "2023" @default.
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