FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322743667> ?p ?o ?g. }

• W4322743667 endingPage "1238" @default.
• W4322743667 startingPage "1238" @default.
• W4322743667 abstract "Health authorities are near universal in their recommendation to replace sugar-sweetened beverages (SSBs) with water. Non-nutritive sweetened beverages (NSBs) are not as widely recommended as a replacement strategy due to a lack of established benefits and concerns they may induce glucose intolerance through changes in the gut microbiome. The STOP Sugars NOW trial aims to assess the effect of the substitution of NSBs (the intended substitution) versus water (the standard of care substitution) for SSBs on glucose tolerance and microbiota diversity.The STOP Sugars NOW trial (NCT03543644) is a pragmatic, head-to-head, open-label, crossover, randomized controlled trial conducted in an outpatient setting. Participants were overweight or obese adults with a high waist circumference who regularly consumed ≥1 SSBs daily. Each participant completed three 4-week treatment phases (usual SSBs, matched NSBs, or water) in random order, which were separated by ≥4-week washout. Blocked randomization was performed centrally by computer with allocation concealment. Outcome assessment was blinded; however, blinding of participants and trial personnel was not possible. The two primary outcomes are oral glucose tolerance (incremental area under the curve) and gut microbiota beta-diversity (weighted UniFrac distance). Secondary outcomes include related markers of adiposity and glucose and insulin regulation. Adherence was assessed by objective biomarkers of added sugars and non-nutritive sweeteners and self-report intake. A subset of participants was included in an Ectopic Fat sub-study in which the primary outcome is intrahepatocellular lipid (IHCL) by 1H-MRS. Analyses will be according to the intention to treat principle.Recruitment began on 1 June 2018, and the last participant completed the trial on 15 October 2020. We screened 1086 participants, of whom 80 were enrolled and randomized in the main trial and 32 of these were enrolled and randomized in the Ectopic Fat sub-study. The participants were predominantly middle-aged (mean age 41.8 ± SD 13.0 y) and had obesity (BMI of 33.7 ± 6.8 kg/m2) with a near equal ratio of female: male (51%:49%). The average baseline SSB intake was 1.9 servings/day. SSBs were replaced with matched NSB brands, sweetened with either a blend of aspartame and acesulfame-potassium (95%) or sucralose (5%).Baseline characteristics for both the main and Ectopic Fat sub-study meet our inclusion criteria and represent a group with overweight or obesity, with characteristics putting them at risk for type 2 diabetes. Findings will be published in peer-reviewed open-access medical journals and provide high-level evidence to inform clinical practice guidelines and public health policy for the use NSBs in sugars reduction strategies.ClinicalTrials.gov identifier, NCT03543644." @default.
• W4322743667 created "2023-03-03" @default.
• W4322743667 creator A5001516546 @default.
• W4322743667 creator A5005475705 @default.
• W4322743667 creator A5005693066 @default.
• W4322743667 creator A5015414747 @default.
• W4322743667 creator A5018513549 @default.
• W4322743667 creator A5024759598 @default.
• W4322743667 creator A5027965558 @default.
• W4322743667 creator A5029481995 @default.
• W4322743667 creator A5030229604 @default.
• W4322743667 creator A5035911645 @default.
• W4322743667 creator A5037636324 @default.
• W4322743667 creator A5040539181 @default.
• W4322743667 creator A5047041312 @default.
• W4322743667 creator A5059816717 @default.
• W4322743667 creator A5060315652 @default.
• W4322743667 creator A5063609672 @default.
• W4322743667 creator A5063644691 @default.
• W4322743667 creator A5065718701 @default.
• W4322743667 creator A5070413623 @default.
• W4322743667 creator A5077175395 @default.
• W4322743667 creator A5080414941 @default.
• W4322743667 creator A5080691435 @default.
• W4322743667 creator A5081624902 @default.
• W4322743667 date "2023-02-28" @default.
• W4322743667 modified "2023-10-03" @default.
• W4322743667 title "Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study" @default.
• W4322743667 cites W1596515083 @default.
• W4322743667 cites W1968008536 @default.
• W4322743667 cites W1989947363 @default.
• W4322743667 cites W1993299437 @default.
• W4322743667 cites W1996583810 @default.
• W4322743667 cites W2011667745 @default.
• W4322743667 cites W2020214777 @default.
• W4322743667 cites W2021908918 @default.
• W4322743667 cites W2023300718 @default.
• W4322743667 cites W2035066415 @default.
• W4322743667 cites W2052848339 @default.
• W4322743667 cites W2066503141 @default.
• W4322743667 cites W2081270681 @default.
• W4322743667 cites W2098558143 @default.
• W4322743667 cites W2102312935 @default.
• W4322743667 cites W2107732097 @default.
• W4322743667 cites W2110300022 @default.
• W4322743667 cites W2111946630 @default.
• W4322743667 cites W2115654907 @default.
• W4322743667 cites W2119878811 @default.
• W4322743667 cites W2133795831 @default.
• W4322743667 cites W2134968997 @default.
• W4322743667 cites W2143104968 @default.
• W4322743667 cites W2145025818 @default.
• W4322743667 cites W2154212775 @default.
• W4322743667 cites W2156773567 @default.
• W4322743667 cites W2160234571 @default.
• W4322743667 cites W2163234420 @default.
• W4322743667 cites W2164366280 @default.
• W4322743667 cites W2164531314 @default.
• W4322743667 cites W2164655298 @default.
• W4322743667 cites W2170024099 @default.
• W4322743667 cites W2171131656 @default.
• W4322743667 cites W2178586826 @default.
• W4322743667 cites W2202529936 @default.
• W4322743667 cites W2315760147 @default.
• W4322743667 cites W2316084138 @default.
• W4322743667 cites W2337254011 @default.
• W4322743667 cites W2534167096 @default.
• W4322743667 cites W2592501403 @default.
• W4322743667 cites W2605052214 @default.
• W4322743667 cites W2607031541 @default.
• W4322743667 cites W2616631710 @default.
• W4322743667 cites W2617575448 @default.
• W4322743667 cites W2621835653 @default.
• W4322743667 cites W2623226437 @default.
• W4322743667 cites W2734494266 @default.
• W4322743667 cites W2765317088 @default.
• W4322743667 cites W2770896795 @default.
• W4322743667 cites W2793601891 @default.
• W4322743667 cites W2806428173 @default.
• W4322743667 cites W2809659531 @default.
• W4322743667 cites W2810783973 @default.
• W4322743667 cites W2892151012 @default.
• W4322743667 cites W2907742136 @default.
• W4322743667 cites W2908219301 @default.
• W4322743667 cites W2921424591 @default.
• W4322743667 cites W2946590740 @default.
• W4322743667 cites W2946710786 @default.
• W4322743667 cites W2954790846 @default.
• W4322743667 cites W2963276645 @default.
• W4322743667 cites W2981035061 @default.
• W4322743667 cites W2985102296 @default.
• W4322743667 cites W2987187089 @default.
• W4322743667 cites W2999139663 @default.
• W4322743667 cites W2999954317 @default.
• W4322743667 cites W3000306948 @default.
• W4322743667 cites W3014022032 @default.
• W4322743667 cites W3031800946 @default.
• W4322743667 cites W3087409922 @default.

• next