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• W4322745086 abstract "Abstract Deuterium oxide (D 2 O) is a water molecule in which both hydrogens are replaced by the heavier and rare isotope deuterium. We have previously shown that D 2 O has distinct sweet taste, which is mediated by the T1R2/T1R3 sweet taste receptor. Here we explore the effect of heavy water on T1R2 and T1R3 subunits. We show that D 2 O activates T1R3 transfected HEK293T cells similarly to T1R2/T1R3 transfected cells. The response to glucose dissolved in D 2 O is higher than to glucose dissolved in water. Mutations of Phenylalanine at position 730 5.40 in the transmembrane domain of T1R3 to Alanine, Leucine or Tyrosine, impair or diminish activation by D 2 O, suggesting a critical role for T1R3 TMD domain in relaying the heavy water signal." @default.
• W4322745086 created "2023-03-03" @default.
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• W4322745086 date "2023-02-28" @default.
• W4322745086 modified "2023-09-28" @default.
• W4322745086 title "T1R3 subunit of the sweet taste receptor is activated by D₂O in transmembrane domain-dependent manner" @default.
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• W4322745086 doi "https://doi.org/10.1101/2023.02.28.530404" @default.
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