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- W4322753561 endingPage "2459" @default.
- W4322753561 startingPage "2441" @default.
- W4322753561 abstract "Abstract The production of high‐quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically associated with the proteotoxic stress induced upon aberrant accumulation of off‐pathway protein folding intermediates, which eventually culminate in the induction of apoptosis. In this review, we will discuss advances in cell engineering and their applications at different hierarchical levels of control of the expression of recombinant proteins, from transcription and translational to posttranslational modifications and subcellular trafficking. We also highlight challenges and unique opportunities to apply modern synthetic biology tools to the design of programmable cell factories for improved biomanufacturing of therapeutic proteins." @default.
- W4322753561 created "2023-03-03" @default.
- W4322753561 creator A5031614171 @default.
- W4322753561 creator A5043748014 @default.
- W4322753561 creator A5077042737 @default.
- W4322753561 creator A5079166027 @default.
- W4322753561 date "2023-03-11" @default.
- W4322753561 modified "2023-10-12" @default.
- W4322753561 title "Cell factory engineering: Challenges and opportunities for synthetic biology applications" @default.
- W4322753561 cites W1540853973 @default.
- W4322753561 cites W1592578892 @default.
- W4322753561 cites W1624756048 @default.
- W4322753561 cites W1645305843 @default.
- W4322753561 cites W1908675203 @default.
- W4322753561 cites W1966212700 @default.
- W4322753561 cites W1967156547 @default.
- W4322753561 cites W1969770714 @default.
- W4322753561 cites W1977855308 @default.
- W4322753561 cites W1982054041 @default.
- W4322753561 cites W1985719186 @default.
- W4322753561 cites W1990345672 @default.
- W4322753561 cites W1993617984 @default.
- W4322753561 cites W1994251377 @default.
- W4322753561 cites W2000853857 @default.
- W4322753561 cites W2005844368 @default.
- W4322753561 cites W2008487520 @default.
- W4322753561 cites W2010385141 @default.
- W4322753561 cites W2017907556 @default.
- W4322753561 cites W2026757351 @default.
- W4322753561 cites W2029339959 @default.
- W4322753561 cites W2034329045 @default.
- W4322753561 cites W2036460884 @default.
- W4322753561 cites W2037735567 @default.
- W4322753561 cites W2044791218 @default.
- W4322753561 cites W2048162805 @default.
- W4322753561 cites W2048941695 @default.
- W4322753561 cites W2049322319 @default.
- W4322753561 cites W2050870581 @default.
- W4322753561 cites W2050982262 @default.
- W4322753561 cites W2052668971 @default.
- W4322753561 cites W2055456683 @default.
- W4322753561 cites W2059127858 @default.
- W4322753561 cites W2060379553 @default.
- W4322753561 cites W2061738853 @default.
- W4322753561 cites W2061954697 @default.
- W4322753561 cites W2062410066 @default.
- W4322753561 cites W2063379481 @default.
- W4322753561 cites W2068160568 @default.
- W4322753561 cites W2070729846 @default.
- W4322753561 cites W2071919990 @default.
- W4322753561 cites W2074531605 @default.
- W4322753561 cites W2075414171 @default.
- W4322753561 cites W2079385933 @default.
- W4322753561 cites W2079933818 @default.
- W4322753561 cites W2081306620 @default.
- W4322753561 cites W2081346742 @default.
- W4322753561 cites W2082348310 @default.
- W4322753561 cites W2082401264 @default.
- W4322753561 cites W2089269966 @default.
- W4322753561 cites W2091239325 @default.
- W4322753561 cites W2093238184 @default.
- W4322753561 cites W2094068725 @default.
- W4322753561 cites W2096731906 @default.
- W4322753561 cites W2098767990 @default.
- W4322753561 cites W2102232272 @default.
- W4322753561 cites W2108422551 @default.
- W4322753561 cites W2110371202 @default.
- W4322753561 cites W2111648798 @default.
- W4322753561 cites W2118540273 @default.
- W4322753561 cites W2118628900 @default.
- W4322753561 cites W2119310960 @default.
- W4322753561 cites W2121074166 @default.
- W4322753561 cites W2122563582 @default.
- W4322753561 cites W2127280148 @default.
- W4322753561 cites W2128163162 @default.
- W4322753561 cites W2129658913 @default.
- W4322753561 cites W2130005269 @default.
- W4322753561 cites W2130912501 @default.
- W4322753561 cites W2131946590 @default.
- W4322753561 cites W2133003674 @default.
- W4322753561 cites W2133020642 @default.
- W4322753561 cites W2134759932 @default.
- W4322753561 cites W2140370795 @default.
- W4322753561 cites W2142660163 @default.
- W4322753561 cites W2143090746 @default.
- W4322753561 cites W2145668963 @default.
- W4322753561 cites W2151722718 @default.
- W4322753561 cites W2152155460 @default.
- W4322753561 cites W2161463357 @default.
- W4322753561 cites W2162695817 @default.
- W4322753561 cites W2163902333 @default.
- W4322753561 cites W2167574642 @default.
- W4322753561 cites W2167578708 @default.
- W4322753561 cites W2168072557 @default.
- W4322753561 cites W2171567367 @default.
- W4322753561 cites W2172134808 @default.
- W4322753561 cites W2182456467 @default.
- W4322753561 cites W2186082751 @default.