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• W4322754753 abstract "Abstract Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these subtypes may not be as distinct as previously thought. Patients with luminal-like, estrogen receptor (ER)-expressing tumors have better prognosis than patients with more aggressive, triple-negative or basal-like tumors. There is, however, a subset of luminal-like tumors that express lower levels of ER, which exhibit more basal-like features. We have found that breast tumors expressing lower levels of ER, traditionally considered to be luminal-like, represent a distinct subset of breast cancer characterized by the emergence of basal-like features. Lineage tracing of low-ER tumors in the MMTV-PyMT mouse mammary tumor model revealed that basal marker-expressing cells arose from normal luminal epithelial cells, suggesting that luminal-to-basal plasticity is responsible for the evolution and emergence of basal-like characteristics. This plasticity allows tumor cells to gain a new lumino-basal phenotype, thus leading to intratumoral lumino-basal heterogeneity. Single-cell RNA sequencing revealed SOX10 as a potential driver for this plasticity, which is known among breast tumors to be almost exclusively expressed in triple-negative breast cancer (TNBC) and was also found to be highly expressed in low-ER tumors. These findings suggest that basal-like tumors may result from the evolutionary progression of luminal tumors with low ER expression." @default.
• W4322754753 created "2023-03-03" @default.
• W4322754753 creator A5007096218 @default.
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• W4322754753 date "2023-03-01" @default.
• W4322754753 modified "2023-10-09" @default.
• W4322754753 title "Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits" @default.
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• W4322754753 doi "https://doi.org/10.1186/s13058-023-01621-8" @default.
• W4322754753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36859337" @default.
• W4322754753 hasPublicationYear "2023" @default.
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