FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322754807> ?p ?o ?g. }

• W4322754807 endingPage "742" @default.
• W4322754807 startingPage "742" @default.
• W4322754807 abstract "Statins are currently the treatment of choice for hypercholesterolemia. However, wide interindividual variability has been observed in the response to treatment. Recent studies have reported the role of lncRNAs in the metabolism of lipids; nevertheless, there are few studies to date that show their role in the response to treatment with statins. Thus, the aim of this study was to assess the levels of expression of three lncRNAs (RP1-13D10.2; MANTIS; lncHR1) associated with genes involved in cholesterol homeostasis in leukocyte cells of hypercholesterolemic patients after treatment with atorvastatin and compare them with levels in subjects with normal cholesterol levels. A secondary aim was to assess the levels of expression in monocytic THP-1 cells differentiated to macrophages. The study included 20 subjects with normal cholesterol (NC) levels and 20 individuals with hypercholesterolemia (HC). The HC patients were treated with atorvastatin (20 mg/day/4 weeks). THP-1 cells were differentiated to macrophages with PMA and treated with different doses of atorvastatin for 24 h. Expression of lncRNAs was determined by RT-qPCR. The lncRNAs RP1-13D10.2 (p < 0.0001), MANTIS (p = 0.0013) and lncHR1 (p < 0.0001) presented increased expression in HC subjects compared with NC subjects. Furthermore, atorvastatin had a negative regulatory effect on the expression of lncHR1 (p < 0.0001) in HC subjects after treatment. In vitro, all the lncRNAs showed significant differences in expression after atorvastatin treatment. Our findings show that the lncRNAs tested present differential expression in HC patients and play a role in the variability reported in the response to atorvastatin treatment. Further research is needed to clarify the biological impact of these lncRNAs on cholesterol homeostasis and treatment with statins." @default.
• W4322754807 created "2023-03-03" @default.
• W4322754807 creator A5000568007 @default.
• W4322754807 creator A5013238614 @default.
• W4322754807 creator A5021771055 @default.
• W4322754807 creator A5036310540 @default.
• W4322754807 creator A5039626176 @default.
• W4322754807 creator A5064735758 @default.
• W4322754807 date "2023-03-01" @default.
• W4322754807 modified "2023-09-26" @default.
• W4322754807 title "Cholesterol-Related lncRNAs as Response Predictors of Atorvastatin Treatment in Chilean Hypercholesterolemic Patients: A Pilot Study" @default.
• W4322754807 cites W1480408416 @default.
• W4322754807 cites W1890772623 @default.
• W4322754807 cites W1964431684 @default.
• W4322754807 cites W1965656498 @default.
• W4322754807 cites W1972348350 @default.
• W4322754807 cites W1989600848 @default.
• W4322754807 cites W1996651828 @default.
• W4322754807 cites W2008918627 @default.
• W4322754807 cites W2017602185 @default.
• W4322754807 cites W2023562174 @default.
• W4322754807 cites W2035190535 @default.
• W4322754807 cites W2043180355 @default.
• W4322754807 cites W2045705754 @default.
• W4322754807 cites W2049544117 @default.
• W4322754807 cites W2054539038 @default.
• W4322754807 cites W2055916074 @default.
• W4322754807 cites W2058982925 @default.
• W4322754807 cites W2076834039 @default.
• W4322754807 cites W2094501252 @default.
• W4322754807 cites W2096010571 @default.
• W4322754807 cites W2102347376 @default.
• W4322754807 cites W2106343349 @default.
• W4322754807 cites W2116404316 @default.
• W4322754807 cites W2117642721 @default.
• W4322754807 cites W2123611509 @default.
• W4322754807 cites W2132755204 @default.
• W4322754807 cites W2282741333 @default.
• W4322754807 cites W2339915731 @default.
• W4322754807 cites W2593823350 @default.
• W4322754807 cites W2594758019 @default.
• W4322754807 cites W2598871689 @default.
• W4322754807 cites W2772479564 @default.
• W4322754807 cites W2793873228 @default.
• W4322754807 cites W2800729482 @default.
• W4322754807 cites W2805241478 @default.
• W4322754807 cites W2882993121 @default.
• W4322754807 cites W2890371049 @default.
• W4322754807 cites W2899351992 @default.
• W4322754807 cites W2945161807 @default.
• W4322754807 cites W2945455613 @default.
• W4322754807 cites W2945535530 @default.
• W4322754807 cites W2950789731 @default.
• W4322754807 cites W2968085309 @default.
• W4322754807 cites W2990851885 @default.
• W4322754807 cites W2992082558 @default.
• W4322754807 cites W3042819427 @default.
• W4322754807 cites W3095776943 @default.
• W4322754807 cites W3128040544 @default.
• W4322754807 cites W3169182666 @default.
• W4322754807 doi "https://doi.org/10.3390/biomedicines11030742" @default.
• W4322754807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36979720" @default.
• W4322754807 hasPublicationYear "2023" @default.
• W4322754807 type Work @default.
• W4322754807 citedByCount "0" @default.
• W4322754807 crossrefType "journal-article" @default.
• W4322754807 hasAuthorship W4322754807A5000568007 @default.
• W4322754807 hasAuthorship W4322754807A5013238614 @default.
• W4322754807 hasAuthorship W4322754807A5021771055 @default.
• W4322754807 hasAuthorship W4322754807A5036310540 @default.
• W4322754807 hasAuthorship W4322754807A5039626176 @default.
• W4322754807 hasAuthorship W4322754807A5064735758 @default.
• W4322754807 hasBestOaLocation W43227548071 @default.
• W4322754807 hasConcept C104950815 @default.
• W4322754807 hasConcept C126322002 @default.
• W4322754807 hasConcept C134018914 @default.
• W4322754807 hasConcept C134651460 @default.
• W4322754807 hasConcept C181199279 @default.
• W4322754807 hasConcept C2777482532 @default.
• W4322754807 hasConcept C2778163477 @default.
• W4322754807 hasConcept C55493867 @default.
• W4322754807 hasConcept C71924100 @default.
• W4322754807 hasConcept C86803240 @default.
• W4322754807 hasConcept C98274493 @default.
• W4322754807 hasConceptScore W4322754807C104950815 @default.
• W4322754807 hasConceptScore W4322754807C126322002 @default.
• W4322754807 hasConceptScore W4322754807C134018914 @default.
• W4322754807 hasConceptScore W4322754807C134651460 @default.
• W4322754807 hasConceptScore W4322754807C181199279 @default.
• W4322754807 hasConceptScore W4322754807C2777482532 @default.
• W4322754807 hasConceptScore W4322754807C2778163477 @default.
• W4322754807 hasConceptScore W4322754807C55493867 @default.
• W4322754807 hasConceptScore W4322754807C71924100 @default.
• W4322754807 hasConceptScore W4322754807C86803240 @default.
• W4322754807 hasConceptScore W4322754807C98274493 @default.
• W4322754807 hasIssue "3" @default.
• W4322754807 hasLocation W43227548071 @default.
• W4322754807 hasLocation W43227548072 @default.

• next