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- W4322756410 abstract "ObjectiveThe efficacy of the mechanistic target of rapamycin inhibitor, sirolimus, was recently reported for patients more than 6 years of age by Kato et al. We evaluated the efficacy and safety of sirolimus in a 2-year-old patient with recurrent focal seizures with impaired consciousness after focal cortical dysplasia (FCD) type IIa resection.MethodsThe patient was a 2-year-old girl who had recurrent seizures after undergoing FCD resection at 4 months of age. The initial dose of sirolimus was 0.5 mg/day and was gradually increased using the trough blood concentration before oral administration as an index, and evaluation was performed at 92 weeks.ResultsThe trough blood level of sirolimus was increased to 6.1 ng/mL and maintenance therapy was started at 40 weeks. Focal seizures with impairment of consciousness with tonic extension of the limbs decreased. No critically serious adverse events occurred.ConclusionSirolimus was effective against epileptic seizures from FCD type II even for a child under 5 years of age. There were no critically serious adverse events and administration could be continued." @default.
- W4322756410 created "2023-03-03" @default.
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- W4322756410 date "2023-06-01" @default.
- W4322756410 modified "2023-09-30" @default.
- W4322756410 title "Efficacy of sirolimus for epileptic seizures in childhood associated with focal cortical dysplasia type II" @default.
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- W4322756410 doi "https://doi.org/10.1016/j.braindev.2023.02.005" @default.
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