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• W4322757414 abstract "Global fluctuation dispersion (FDglobal), a spatial-temporal metric derived from serial images of the pulmonary perfusion obtained with MRI-arterial spin labeling, describes temporal fluctuations in the spatial distribution of perfusion. In healthy subjects, FDglobal is increased by hyperoxia, hypoxia and inhaled nitric oxide. We evaluated patients with pulmonary arterial hypertension (PAH, 4F, aged 47±15, mean pulmonary artery pressure 48±7 mmHg) and healthy controls (CON, 7F, aged 47±12) to test the hypothesis that FDglobal is increased in PAH. Images were acquired at ~4-5 second intervals during voluntary respiratory gating, inspected for quality, registered using a deformable registration algorithm and normalized. Spatial relative dispersion (RD = SD/mean) and the percent of the lung image with no measurable perfusion signal (%NMP) were also assessed. FDglobal was significantly increased in PAH (PAH=0.40±0.17, CON=0.17±0.02, p=0.006, a 135% increase) with no overlap in values between the two groups, consistent with altered vascular regulation. Both spatial RD and %NMP were also markedly greater in PAH vs. CON (PAH RD=1.46±0.24, CON=0.90±0.10, p = 0.0004; PAH NMP=13.4±6.1%; CON=2.3±1.4%, p=0.001 respectively) consistent with vascular remodeling resulting in poorly perfused regions of lung and increased spatial heterogeneity. The difference in FDglobal between normal subjects and PAH patients in this small cohort suggests that spatial-temporal imaging of perfusion may be useful in evaluation of patients with PAH. Since this MR imaging technique uses no injected contrast agents and has no ionizing radiation it may be suitable for use in diverse patient populations." @default.
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• W4322757414 date "2023-03-02" @default.
• W4322757414 modified "2023-09-26" @default.
• W4322757414 title "The spatial temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension" @default.
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• W4322757414 doi "https://doi.org/10.1152/japplphysiol.00463.2022" @default.
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• W4322757414 hasPublicationYear "2023" @default.
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