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- W4322757503 abstract "Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response." @default.
- W4322757503 created "2023-03-03" @default.
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- W4322757503 date "2023-03-02" @default.
- W4322757503 modified "2023-10-15" @default.
- W4322757503 title "Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells" @default.
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- W4322757503 doi "https://doi.org/10.7554/elife.83908" @default.
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