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• W4322757673 abstract "Background Radiotherapy (RT) combined with chemotherapy is the standard treatment for T 1-2 N 1 M 0 nasopharyngeal carcinoma (NPC) based on conventional radiotherapy. However, intensity-modulated radiotherapy (IMRT) has narrowed the treatment gap between RT and chemoradiotherapy. Thus, this retrospective study aimed to compare the efficacy of RT and chemoradiotherapy (RT-chemo) in treating T 1-2 N 1 M 0 NPC in the IMRT era. Materials and methods From January 2008 to December 2016, 343 consecutive patients with T 1-2 N 1 M 0 NPC in two cancer centers were included. All patients received RT or RT-chemo, chemotherapy including induction chemotherapy (IC) + concurrent chemoradiotherapy (CCRT), CCRT, or CCRT + adjuvant chemotherapy (AC). The number of patients who received RT, CCRT, IC + CCRT, and CCRT + AC was 114, 101, 89, and 39. The survival rates were analyzed using the Kaplan-Meier method and compared using the log-rank test. Multivariable analysis was performed to identify valuable prognostic factors. Results The median follow-up time for survivors was 93 (range: 55–144) months. The 5-year overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFFS), and distant metastasis-free survival (DMFS) for the RT-chemo and RT groups were 93.7%, 88.5%, 93.8%, 93.8% and 93.0%, 87.7%, 91.9%, 91.2%, respectively (P>0.05 for all outcomes). No significant survival differences were found between the two groups. The T 1 N 1 M 0 or T 2 N 1 M 0 subgroup analysis showed that treatment outcomes had no significant differences between the RT and RT-chemo groups. After adjusting for various factors, treatment mode was not identified as an independent prognostic factor for all survival rates. Conclusions In this study, outcomes of T 1-2 N 1 M 0 NPC patients treated by IMRT alone were comparable to chemoradiotherapy, supporting the omission or postponement of chemotherapy." @default.
• W4322757673 created "2023-03-03" @default.
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• W4322757673 date "2023-03-02" @default.
• W4322757673 modified "2023-09-25" @default.
• W4322757673 title "T1-2N1M0 nasopharyngeal carcinoma chemotherapy or not: A retrospective study" @default.
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• W4322757673 doi "https://doi.org/10.1371/journal.pone.0279252" @default.
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