FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322757705> ?p ?o ?g. }

• W4322757705 endingPage "938" @default.
• W4322757705 startingPage "927" @default.
• W4322757705 abstract "The β-lactoglobulin (β-LG) was previously characterized as a mild antioxidant modulating cell viability. However, its biological action regarding endometrial stromal cell cytophysiology and function has never been considered. In this study, we investigated the influence of β-LG on the cellular status of equine endometrial progenitor cells under oxidative stress. The study showed that β-LG decreased the intracellular accumulation of reactive oxygen species, simultaneously ameliorating cell viability and exerting an anti-apoptotic effect. However, at the transcriptional level, the reduced mRNA expression of pro-apoptotic factors (i.e. BAX and BAD) was accompanied by decreased expression of mRNA for anti-apoptotic BCL-2 and genes coding antioxidant enzymes (CAT, SOD-1, GPx). Still, we have also noted the positive effect of β-LG on the expression profile of transcripts involved in endometrial viability and receptivity, including ITGB1, ENPP3, TUNAR and miR-19b-3p. Finally, the expression of master factors of endometrial decidualization, namely prolactin and IGFBP1, was increased in response to β-LG, while non-coding RNAs (ncRNAs), that is lncRNA MALAT1 and miR-200b-3p, were upregulated. Our findings indicate a novel potential role of β-LG as a molecule regulating endometrial tissue functionality, promoting viability and normalizing the oxidative status of endometrial progenitor cells. The possible mechanism of β-LG action includes the activation of ncRNAs essential for tissue regeneration, such as lncRNA MALAT-1/TUNAR and miR-19b-3p/miR-200b-3p." @default.
• W4322757705 created "2023-03-03" @default.
• W4322757705 creator A5004100380 @default.
• W4322757705 creator A5010740751 @default.
• W4322757705 creator A5033242241 @default.
• W4322757705 creator A5035282778 @default.
• W4322757705 creator A5048904319 @default.
• W4322757705 creator A5054043673 @default.
• W4322757705 date "2023-03-01" @default.
• W4322757705 modified "2023-10-14" @default.
• W4322757705 title "β‐Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via <scp>lncRNA‐mRNA‐miRNA</scp> regulatory associations" @default.
• W4322757705 cites W1990044641 @default.
• W4322757705 cites W2068653318 @default.
• W4322757705 cites W2098394596 @default.
• W4322757705 cites W2109955836 @default.
• W4322757705 cites W2135935849 @default.
• W4322757705 cites W2137657922 @default.
• W4322757705 cites W2238902725 @default.
• W4322757705 cites W2255201069 @default.
• W4322757705 cites W2341322856 @default.
• W4322757705 cites W2511430792 @default.
• W4322757705 cites W2580639094 @default.
• W4322757705 cites W2609479259 @default.
• W4322757705 cites W2612998770 @default.
• W4322757705 cites W2767225262 @default.
• W4322757705 cites W2768143155 @default.
• W4322757705 cites W2793805814 @default.
• W4322757705 cites W2796002221 @default.
• W4322757705 cites W2897587300 @default.
• W4322757705 cites W2899764141 @default.
• W4322757705 cites W2913162659 @default.
• W4322757705 cites W2969699662 @default.
• W4322757705 cites W2980266362 @default.
• W4322757705 cites W2986763958 @default.
• W4322757705 cites W2990485520 @default.
• W4322757705 cites W2999441816 @default.
• W4322757705 cites W3003222858 @default.
• W4322757705 cites W3008744916 @default.
• W4322757705 cites W3010944073 @default.
• W4322757705 cites W3012695622 @default.
• W4322757705 cites W3019157072 @default.
• W4322757705 cites W3046227666 @default.
• W4322757705 cites W3056456130 @default.
• W4322757705 cites W3082205591 @default.
• W4322757705 cites W3095757747 @default.
• W4322757705 cites W3105002027 @default.
• W4322757705 cites W3118799583 @default.
• W4322757705 cites W3128541551 @default.
• W4322757705 cites W3134580842 @default.
• W4322757705 cites W3145436549 @default.
• W4322757705 cites W3160757571 @default.
• W4322757705 cites W3165711336 @default.
• W4322757705 cites W4210503393 @default.
• W4322757705 cites W4220722119 @default.
• W4322757705 cites W4221078198 @default.
• W4322757705 cites W4224317961 @default.
• W4322757705 cites W4224322090 @default.
• W4322757705 cites W4281561324 @default.
• W4322757705 cites W4287147707 @default.
• W4322757705 cites W4322757705 @default.
• W4322757705 doi "https://doi.org/10.1111/jcmm.17694" @default.
• W4322757705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36860157" @default.
• W4322757705 hasPublicationYear "2023" @default.
• W4322757705 type Work @default.
• W4322757705 citedByCount "2" @default.
• W4322757705 countsByYear W43227577052023 @default.
• W4322757705 crossrefType "journal-article" @default.
• W4322757705 hasAuthorship W4322757705A5004100380 @default.
• W4322757705 hasAuthorship W4322757705A5010740751 @default.
• W4322757705 hasAuthorship W4322757705A5033242241 @default.
• W4322757705 hasAuthorship W4322757705A5035282778 @default.
• W4322757705 hasAuthorship W4322757705A5048904319 @default.
• W4322757705 hasAuthorship W4322757705A5054043673 @default.
• W4322757705 hasBestOaLocation W43227577051 @default.
• W4322757705 hasConcept C104317684 @default.
• W4322757705 hasConcept C134018914 @default.
• W4322757705 hasConcept C145059251 @default.
• W4322757705 hasConcept C16930146 @default.
• W4322757705 hasConcept C190283241 @default.
• W4322757705 hasConcept C201750760 @default.
• W4322757705 hasConcept C2776151105 @default.
• W4322757705 hasConcept C28328180 @default.
• W4322757705 hasConcept C502942594 @default.
• W4322757705 hasConcept C53227056 @default.
• W4322757705 hasConcept C55493867 @default.
• W4322757705 hasConcept C86803240 @default.
• W4322757705 hasConcept C95444343 @default.
• W4322757705 hasConceptScore W4322757705C104317684 @default.
• W4322757705 hasConceptScore W4322757705C134018914 @default.
• W4322757705 hasConceptScore W4322757705C145059251 @default.
• W4322757705 hasConceptScore W4322757705C16930146 @default.
• W4322757705 hasConceptScore W4322757705C190283241 @default.
• W4322757705 hasConceptScore W4322757705C201750760 @default.
• W4322757705 hasConceptScore W4322757705C2776151105 @default.
• W4322757705 hasConceptScore W4322757705C28328180 @default.
• W4322757705 hasConceptScore W4322757705C502942594 @default.
• W4322757705 hasConceptScore W4322757705C53227056 @default.
• W4322757705 hasConceptScore W4322757705C55493867 @default.

• next