FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322758257> ?p ?o ?g. }

• W4322758257 endingPage "920" @default.
• W4322758257 startingPage "910" @default.
• W4322758257 abstract "Abstract The introduction of transcutaneous and subcutaneous implants and devices into the human body instigates fouling and foreign body responses (FBRs) that limit their functional lifetimes. Polymer coatings are a promising solution to improve the biocompatibility of such implants, with potential to enhance in vivo device performance and prolong device lifetime. Here we sought to develop novel materials for use as coatings on subcutaneously implanted devices to reduce the FBR and local tissue inflammation in comparison to gold standard materials such as poly(ethylene glycol) and polyzwitterions. We prepared a library of polyacrylamide‐based copolymer hydrogels, which were selected from materials previously shown to exhibit remarkable antifouling properties with blood and plasma, and implanted them into the subcutaneous space of mice to evaluate their biocompatibility over the course of 1 month. The top performing polyacrylamide‐based copolymer hydrogel material, comprising a 50:50 mixture of N ‐(2‐hydroxyethyl)acrylamide (HEAm) and N ‐(3‐methoxypropyl)acrylamide (MPAm), exhibited significantly better biocompatibility and lower tissue inflammation than gold standard materials. Moreover, when applied to polydimethylsiloxane disks or silicon catheters as a thin coating (45 ± 1 μm), this leading copolymer hydrogel coating significantly improved implant biocompatibility. Using a rat model of insulin‐deficient diabetes, we showed that insulin pumps fitted with HEAm‐ co ‐MPAm hydrogel‐coated insulin infusion catheters exhibited improved biocompatibility and extended functional lifetime over pumps fitted with industry standard catheters. These polyacrylamide‐based copolymer hydrogel coatings have the potential to improve device function and lifetime, thereby reducing the burden of disease management for people regularly using implanted devices." @default.
• W4322758257 created "2023-03-03" @default.
• W4322758257 creator A5024165886 @default.
• W4322758257 creator A5045990567 @default.
• W4322758257 creator A5062824120 @default.
• W4322758257 creator A5071485060 @default.
• W4322758257 creator A5079889129 @default.
• W4322758257 creator A5089391222 @default.
• W4322758257 date "2023-03-02" @default.
• W4322758257 modified "2023-10-15" @default.
• W4322758257 title "Polyacrylamide‐based hydrogel coatings improve biocompatibility of implanted pump devices" @default.
• W4322758257 cites W1482515349 @default.
• W4322758257 cites W1509156154 @default.
• W4322758257 cites W1565468145 @default.
• W4322758257 cites W1567481652 @default.
• W4322758257 cites W1984904537 @default.
• W4322758257 cites W1990120142 @default.
• W4322758257 cites W1993342139 @default.
• W4322758257 cites W1996192750 @default.
• W4322758257 cites W2020002897 @default.
• W4322758257 cites W2021881473 @default.
• W4322758257 cites W2034214486 @default.
• W4322758257 cites W2053058794 @default.
• W4322758257 cites W2059542554 @default.
• W4322758257 cites W2067580462 @default.
• W4322758257 cites W2074198606 @default.
• W4322758257 cites W2082043280 @default.
• W4322758257 cites W2093984144 @default.
• W4322758257 cites W2094903240 @default.
• W4322758257 cites W2107835308 @default.
• W4322758257 cites W2128392700 @default.
• W4322758257 cites W2134890518 @default.
• W4322758257 cites W2165248259 @default.
• W4322758257 cites W2191594866 @default.
• W4322758257 cites W2413610930 @default.
• W4322758257 cites W2417458553 @default.
• W4322758257 cites W2470747143 @default.
• W4322758257 cites W2562591732 @default.
• W4322758257 cites W2563390568 @default.
• W4322758257 cites W2580940777 @default.
• W4322758257 cites W2753556737 @default.
• W4322758257 cites W2759891488 @default.
• W4322758257 cites W2784126038 @default.
• W4322758257 cites W2793244096 @default.
• W4322758257 cites W2884370030 @default.
• W4322758257 cites W2884838252 @default.
• W4322758257 cites W289241723 @default.
• W4322758257 cites W3003603323 @default.
• W4322758257 cites W3023222482 @default.
• W4322758257 cites W4225876719 @default.
• W4322758257 cites W4226151042 @default.
• W4322758257 cites W4288065881 @default.
• W4322758257 doi "https://doi.org/10.1002/jbm.a.37521" @default.
• W4322758257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36861657" @default.
• W4322758257 hasPublicationYear "2023" @default.
• W4322758257 type Work @default.
• W4322758257 citedByCount "4" @default.
• W4322758257 countsByYear W43227582572023 @default.
• W4322758257 crossrefType "journal-article" @default.
• W4322758257 hasAuthorship W4322758257A5024165886 @default.
• W4322758257 hasAuthorship W4322758257A5045990567 @default.
• W4322758257 hasAuthorship W4322758257A5062824120 @default.
• W4322758257 hasAuthorship W4322758257A5071485060 @default.
• W4322758257 hasAuthorship W4322758257A5079889129 @default.
• W4322758257 hasAuthorship W4322758257A5089391222 @default.
• W4322758257 hasBestOaLocation W43227582572 @default.
• W4322758257 hasConcept C108586683 @default.
• W4322758257 hasConcept C127413603 @default.
• W4322758257 hasConcept C136229726 @default.
• W4322758257 hasConcept C15920480 @default.
• W4322758257 hasConcept C159985019 @default.
• W4322758257 hasConcept C171250308 @default.
• W4322758257 hasConcept C188027245 @default.
• W4322758257 hasConcept C191897082 @default.
• W4322758257 hasConcept C192562407 @default.
• W4322758257 hasConcept C2777230088 @default.
• W4322758257 hasConcept C2777516009 @default.
• W4322758257 hasConcept C2778862431 @default.
• W4322758257 hasConcept C2779402116 @default.
• W4322758257 hasConcept C2781448156 @default.
• W4322758257 hasConcept C42360764 @default.
• W4322758257 hasConcept C521977710 @default.
• W4322758257 hasConcept C71924100 @default.
• W4322758257 hasConceptScore W4322758257C108586683 @default.
• W4322758257 hasConceptScore W4322758257C127413603 @default.
• W4322758257 hasConceptScore W4322758257C136229726 @default.
• W4322758257 hasConceptScore W4322758257C15920480 @default.
• W4322758257 hasConceptScore W4322758257C159985019 @default.
• W4322758257 hasConceptScore W4322758257C171250308 @default.
• W4322758257 hasConceptScore W4322758257C188027245 @default.
• W4322758257 hasConceptScore W4322758257C191897082 @default.
• W4322758257 hasConceptScore W4322758257C192562407 @default.
• W4322758257 hasConceptScore W4322758257C2777230088 @default.
• W4322758257 hasConceptScore W4322758257C2777516009 @default.
• W4322758257 hasConceptScore W4322758257C2778862431 @default.
• W4322758257 hasConceptScore W4322758257C2779402116 @default.
• W4322758257 hasConceptScore W4322758257C2781448156 @default.
• W4322758257 hasConceptScore W4322758257C42360764 @default.

• next