Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322763071> ?p ?o ?g. }
- W4322763071 endingPage "369" @default.
- W4322763071 startingPage "359" @default.
- W4322763071 abstract "Background: We previously found a conditioned increase in central neuroinflammatory markers (Interleukin 6; IL-6) following exposure to alcohol-associated cues. Recent studies suggest (unconditioned) induction of IL-6 is entirely dependent on ethanol-induced corticosterone.Objectives: The goals of these present studies were to test whether alcohol-paired cues facilitated the hypothalamic-pituitary-adrenal (HPA) axis response to either a subthreshold priming alcohol dose or an immune or psychological stress challengeMethods: In Experiment 1 (N = 64), adult male Sprague Dawley rats were trained (paired or unpaired, four pairings total) with either vehicle or 2 g/kg alcohol [intragastric (i.g.) or intraperitoneal (i.p.)] injections. In Experiments 2 (N = 28) and 3 (N = 30), male rats were similarly trained but with 4 g/kg alcohol i.g. intubations. On test day, all rats were either administered a 0.5 g/kg alcohol dose (i.p. or i.g. Experiment 1), a 100 µg/kg i.p. lipopolysaccharide (LPS) challenge (Experiment 2), or a restraint challenge (Experiment 3), and exposed to alcohol-associated cues. Blood plasma was collected for analysis.Results: Alcohol-associated cues facilitated the plasma corticosterone response to a subthreshold dose of alcohol (F1,28 = 4.85, p < .05) and an immune challenge (F8,80 = 6.23, p < .001), but not a restraint challenge (F2,27 = 0.18, p > .05).Conclusion: These findings reveal that the impact of the cues associated with alcohol intoxication on the HPA axis may be context-specific. This work illustrates how HPA axis learning processes form in the early stages of alcohol use and has important implications for how the HPA and neuroimmune conditioning may develop in alcohol use disorder in humans and facilitate the response to a later immune challenge." @default.
- W4322763071 created "2023-03-03" @default.
- W4322763071 creator A5036140878 @default.
- W4322763071 creator A5078833825 @default.
- W4322763071 creator A5089954750 @default.
- W4322763071 creator A5091169534 @default.
- W4322763071 date "2023-03-02" @default.
- W4322763071 modified "2023-10-17" @default.
- W4322763071 title "Cues associated with repeated ethanol exposure facilitate the corticosterone response to ethanol and immunological challenges in adult male Sprague Dawley rats: implications for neuroimmune regulation" @default.
- W4322763071 cites W1489713305 @default.
- W4322763071 cites W1541894425 @default.
- W4322763071 cites W1606879955 @default.
- W4322763071 cites W1761714741 @default.
- W4322763071 cites W1970209827 @default.
- W4322763071 cites W1971620345 @default.
- W4322763071 cites W1975999231 @default.
- W4322763071 cites W1978926805 @default.
- W4322763071 cites W1980637329 @default.
- W4322763071 cites W1988586625 @default.
- W4322763071 cites W1999182152 @default.
- W4322763071 cites W2000048752 @default.
- W4322763071 cites W2001217292 @default.
- W4322763071 cites W2006173908 @default.
- W4322763071 cites W2013349612 @default.
- W4322763071 cites W2013940388 @default.
- W4322763071 cites W2017496770 @default.
- W4322763071 cites W2023648659 @default.
- W4322763071 cites W2023703027 @default.
- W4322763071 cites W2024972153 @default.
- W4322763071 cites W2032197162 @default.
- W4322763071 cites W2040682356 @default.
- W4322763071 cites W2045288044 @default.
- W4322763071 cites W2045368329 @default.
- W4322763071 cites W2046960533 @default.
- W4322763071 cites W2054749214 @default.
- W4322763071 cites W2056363230 @default.
- W4322763071 cites W2061463990 @default.
- W4322763071 cites W2062489497 @default.
- W4322763071 cites W2065577847 @default.
- W4322763071 cites W2083443798 @default.
- W4322763071 cites W2084343242 @default.
- W4322763071 cites W2088355418 @default.
- W4322763071 cites W2089248014 @default.
- W4322763071 cites W2091973725 @default.
- W4322763071 cites W2091973738 @default.
- W4322763071 cites W2092568693 @default.
- W4322763071 cites W2094970393 @default.
- W4322763071 cites W2098031897 @default.
- W4322763071 cites W2099338699 @default.
- W4322763071 cites W2104537532 @default.
- W4322763071 cites W2105130852 @default.
- W4322763071 cites W2105576881 @default.
- W4322763071 cites W2106862702 @default.
- W4322763071 cites W2107980868 @default.
- W4322763071 cites W2117619438 @default.
- W4322763071 cites W2127363133 @default.
- W4322763071 cites W2129319296 @default.
- W4322763071 cites W2132539548 @default.
- W4322763071 cites W2134946465 @default.
- W4322763071 cites W2144553613 @default.
- W4322763071 cites W2154710740 @default.
- W4322763071 cites W2161039633 @default.
- W4322763071 cites W2161772805 @default.
- W4322763071 cites W2168148759 @default.
- W4322763071 cites W2179642127 @default.
- W4322763071 cites W2408637989 @default.
- W4322763071 cites W2440066738 @default.
- W4322763071 cites W2552003854 @default.
- W4322763071 cites W2588192428 @default.
- W4322763071 cites W2610249220 @default.
- W4322763071 cites W2610379017 @default.
- W4322763071 cites W2916419921 @default.
- W4322763071 cites W2951902842 @default.
- W4322763071 cites W2981049018 @default.
- W4322763071 cites W2993905113 @default.
- W4322763071 cites W3044886691 @default.
- W4322763071 cites W4220787597 @default.
- W4322763071 cites W4244064286 @default.
- W4322763071 doi "https://doi.org/10.1080/00952990.2023.2169831" @default.
- W4322763071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36862971" @default.
- W4322763071 hasPublicationYear "2023" @default.
- W4322763071 type Work @default.
- W4322763071 citedByCount "1" @default.
- W4322763071 countsByYear W43227630712023 @default.
- W4322763071 crossrefType "journal-article" @default.
- W4322763071 hasAuthorship W4322763071A5036140878 @default.
- W4322763071 hasAuthorship W4322763071A5078833825 @default.
- W4322763071 hasAuthorship W4322763071A5089954750 @default.
- W4322763071 hasAuthorship W4322763071A5091169534 @default.
- W4322763071 hasConcept C126322002 @default.
- W4322763071 hasConcept C134018914 @default.
- W4322763071 hasConcept C151730666 @default.
- W4322763071 hasConcept C15744967 @default.
- W4322763071 hasConcept C178790620 @default.
- W4322763071 hasConcept C185592680 @default.
- W4322763071 hasConcept C190385971 @default.
- W4322763071 hasConcept C203014093 @default.
- W4322763071 hasConcept C2776610969 @default.