FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322766053> ?p ?o ?g. }

• W4322766053 endingPage "129" @default.
• W4322766053 startingPage "117" @default.
• W4322766053 abstract "Alternative splicing is a key posttranscriptional gene regulatory process, acting in diverse adaptive and basal plant processes. Splicing of precursor-messenger RNA (pre-mRNA) is catalyzed by a dynamic ribonucleoprotein complex, designated the spliceosome. In a suppressor screen, we identified a nonsense mutation in the Smith (Sm) antigen protein SME1 to alleviate photorespiratory H2O2-dependent cell death in catalase deficient plants. Similar attenuation of cell death was observed upon chemical inhibition of the spliceosome, suggesting pre-mRNA splicing inhibition to be responsible for the observed cell death alleviation. Furthermore, the sme1-2 mutants showed increased tolerance to the reactive oxygen species inducing herbicide methyl viologen. Both an mRNA-seq and shotgun proteomic analysis in sme1-2 mutants displayed a constitutive molecular stress response, together with extensive alterations in pre-mRNA splicing of transcripts encoding metabolic enzymes and RNA binding proteins, even under unstressed conditions. Using SME1 as a bait to identify protein interactors, we provide experimental evidence for almost 50 homologs of the mammalian spliceosome-associated protein to reside in the Arabidopsis thaliana spliceosome complexes and propose roles in pre-mRNA splicing for four uncharacterized plant proteins. Furthermore, as for sme1-2, a mutant in the Sm core assembly protein ICLN resulted in a decreased sensitivity to methyl viologen. Taken together, these data show that both a perturbed Sm core composition and assembly results in the activation of a defense response and in enhanced resilience to oxidative stress." @default.
• W4322766053 created "2023-03-03" @default.
• W4322766053 creator A5003852387 @default.
• W4322766053 creator A5017123045 @default.
• W4322766053 creator A5020555281 @default.
• W4322766053 creator A5037818756 @default.
• W4322766053 creator A5039149751 @default.
• W4322766053 creator A5048227199 @default.
• W4322766053 creator A5054428875 @default.
• W4322766053 creator A5055042016 @default.
• W4322766053 creator A5059193094 @default.
• W4322766053 creator A5072800163 @default.
• W4322766053 date "2023-05-01" @default.
• W4322766053 modified "2023-10-15" @default.
• W4322766053 title "Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience" @default.
• W4322766053 cites W1502660143 @default.
• W4322766053 cites W1519895850 @default.
• W4322766053 cites W1540124006 @default.
• W4322766053 cites W1799756177 @default.
• W4322766053 cites W1814931954 @default.
• W4322766053 cites W1979204842 @default.
• W4322766053 cites W1981479374 @default.
• W4322766053 cites W1984256629 @default.
• W4322766053 cites W1990214042 @default.
• W4322766053 cites W1992288436 @default.
• W4322766053 cites W1993391297 @default.
• W4322766053 cites W1995011186 @default.
• W4322766053 cites W2009221497 @default.
• W4322766053 cites W2020871612 @default.
• W4322766053 cites W2021341670 @default.
• W4322766053 cites W2030368309 @default.
• W4322766053 cites W2030593666 @default.
• W4322766053 cites W2044962116 @default.
• W4322766053 cites W2048369796 @default.
• W4322766053 cites W2052741765 @default.
• W4322766053 cites W2055849670 @default.
• W4322766053 cites W2063041271 @default.
• W4322766053 cites W2063441353 @default.
• W4322766053 cites W2068346771 @default.
• W4322766053 cites W2073688200 @default.
• W4322766053 cites W2080752012 @default.
• W4322766053 cites W2095577576 @default.
• W4322766053 cites W2095643322 @default.
• W4322766053 cites W2095676095 @default.
• W4322766053 cites W2100065623 @default.
• W4322766053 cites W2108130533 @default.
• W4322766053 cites W2114813386 @default.
• W4322766053 cites W2119204091 @default.
• W4322766053 cites W2125217159 @default.
• W4322766053 cites W2125422443 @default.
• W4322766053 cites W2133760322 @default.
• W4322766053 cites W2138148973 @default.
• W4322766053 cites W2147665732 @default.
• W4322766053 cites W2153833484 @default.
• W4322766053 cites W2157918066 @default.
• W4322766053 cites W2158217645 @default.
• W4322766053 cites W2162840029 @default.
• W4322766053 cites W2163669373 @default.
• W4322766053 cites W2167432290 @default.
• W4322766053 cites W2169456326 @default.
• W4322766053 cites W2169810791 @default.
• W4322766053 cites W2178634736 @default.
• W4322766053 cites W2238689470 @default.
• W4322766053 cites W2268486506 @default.
• W4322766053 cites W2323326409 @default.
• W4322766053 cites W2341861303 @default.
• W4322766053 cites W2405022357 @default.
• W4322766053 cites W2475425734 @default.
• W4322766053 cites W2534587422 @default.
• W4322766053 cites W2593051497 @default.
• W4322766053 cites W2601082459 @default.
• W4322766053 cites W2601763942 @default.
• W4322766053 cites W2605929552 @default.
• W4322766053 cites W2613970209 @default.
• W4322766053 cites W2620721366 @default.
• W4322766053 cites W2624117876 @default.
• W4322766053 cites W2739822974 @default.
• W4322766053 cites W2744783701 @default.
• W4322766053 cites W2747639821 @default.
• W4322766053 cites W2766646187 @default.
• W4322766053 cites W2768985026 @default.
• W4322766053 cites W2773348015 @default.
• W4322766053 cites W2790838834 @default.
• W4322766053 cites W2791532875 @default.
• W4322766053 cites W2869812023 @default.
• W4322766053 cites W2887020392 @default.
• W4322766053 cites W2911571267 @default.
• W4322766053 cites W2945659870 @default.
• W4322766053 cites W2946950202 @default.
• W4322766053 cites W2949317881 @default.
• W4322766053 cites W2977748395 @default.
• W4322766053 cites W2982462899 @default.
• W4322766053 cites W3029246177 @default.
• W4322766053 cites W3166626292 @default.
• W4322766053 cites W3172030433 @default.
• W4322766053 cites W4226450259 @default.
• W4322766053 cites W4322496347 @default.
• W4322766053 doi "https://doi.org/10.1016/j.freeradbiomed.2023.02.025" @default.

• next