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- W4322769904 endingPage "615" @default.
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- W4322769904 abstract "Most effective anticancer drugs normally generate considerable cytotoxicity in normal cells; therefore, the preferential activation of apoptosis in cancer cells and the reduction of toxicity in normal cells is a great challenge in cancer research. Natural products with selective anticancer properties used as complementary medicine can help to achieve this goal. The aim of the present study was to analyze the effect of the addition of bee products [propolis (PR) or royal jelly (RJ) or propolis and royal jelly (PR+RJ), 2-10%] to thyme (TH) and chestnut honeys (CH) on the differential anticancer properties, mainly the cytotoxic and pro-apoptotic effects, in normal and cancer hepatic cells. The cytotoxic effects of samples were analyzed using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (0-250 mg/mL) and the effects on apoptosis were analyzed using cell cycle analysis, TdT-dUTP terminal nick-end labeling (TUNEL) assay, DR5 (Death Receptor 5) and BAX (BCL-2-Associated X) activation, and caspases 8, 9, and 3 activities. Both honey samples alone and honey mixtures had no or very little apoptotic effect on normal cells. Antioxidant honey mixtures enhanced the apoptotic capacity of the corresponding honey alone via both extrinsic and intrinsic pathways. Of all the samples, chestnut honey enriched with 10% royal jelly and 10% propolis (sample 14, CH+10RJ+10PR) showed the highest apoptotic effect on tumor liver cells. The enrichment of monofloral honey with bee products could be used together with conventional anticancer treatments as a dietary supplement without side effects. On the other hand, it could be included in the diet as a natural sweetener with high added value." @default.
- W4322769904 created "2023-03-03" @default.
- W4322769904 creator A5003338339 @default.
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- W4322769904 creator A5068082756 @default.
- W4322769904 creator A5089301204 @default.
- W4322769904 date "2023-03-02" @default.
- W4322769904 modified "2023-09-30" @default.
- W4322769904 title "Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells" @default.
- W4322769904 cites W1648586995 @default.
- W4322769904 cites W1799139420 @default.
- W4322769904 cites W1850437306 @default.
- W4322769904 cites W1970370302 @default.
- W4322769904 cites W1970599905 @default.
- W4322769904 cites W1973425872 @default.
- W4322769904 cites W1984119283 @default.
- W4322769904 cites W1989824400 @default.
- W4322769904 cites W1999703394 @default.
- W4322769904 cites W2007436085 @default.
- W4322769904 cites W2018422420 @default.
- W4322769904 cites W2058824430 @default.
- W4322769904 cites W2073526237 @default.
- W4322769904 cites W2074305443 @default.
- W4322769904 cites W2085167150 @default.
- W4322769904 cites W2088653807 @default.
- W4322769904 cites W2094942223 @default.
- W4322769904 cites W2114487246 @default.
- W4322769904 cites W2122138116 @default.
- W4322769904 cites W2130366211 @default.
- W4322769904 cites W2130631177 @default.
- W4322769904 cites W2133190342 @default.
- W4322769904 cites W2134855813 @default.
- W4322769904 cites W2139390614 @default.
- W4322769904 cites W2148831641 @default.
- W4322769904 cites W2161721565 @default.
- W4322769904 cites W2254244635 @default.
- W4322769904 cites W2260702953 @default.
- W4322769904 cites W2311464408 @default.
- W4322769904 cites W2439720628 @default.
- W4322769904 cites W2513414068 @default.
- W4322769904 cites W2557531334 @default.
- W4322769904 cites W2558292694 @default.
- W4322769904 cites W2587334976 @default.
- W4322769904 cites W2759651904 @default.
- W4322769904 cites W2782628808 @default.
- W4322769904 cites W2795761050 @default.
- W4322769904 cites W2888734518 @default.
- W4322769904 cites W2891957518 @default.
- W4322769904 cites W2897894723 @default.
- W4322769904 cites W2905814117 @default.
- W4322769904 cites W2906831992 @default.
- W4322769904 cites W2912429260 @default.
- W4322769904 cites W2918429612 @default.
- W4322769904 cites W2921557918 @default.
- W4322769904 cites W2946241862 @default.
- W4322769904 cites W2946332407 @default.
- W4322769904 cites W2949780892 @default.
- W4322769904 cites W2963972381 @default.
- W4322769904 cites W2964729726 @default.
- W4322769904 cites W2969223396 @default.
- W4322769904 cites W2970084765 @default.
- W4322769904 cites W2974965336 @default.
- W4322769904 cites W3013001854 @default.
- W4322769904 cites W3023359242 @default.
- W4322769904 cites W3023725765 @default.
- W4322769904 cites W3031188436 @default.
- W4322769904 cites W3037420185 @default.
- W4322769904 cites W3045034417 @default.
- W4322769904 cites W3093071097 @default.
- W4322769904 cites W3095895841 @default.
- W4322769904 cites W3120408098 @default.
- W4322769904 cites W3126953007 @default.
- W4322769904 cites W3133886461 @default.
- W4322769904 cites W3138848156 @default.
- W4322769904 cites W3164205630 @default.
- W4322769904 cites W3173583182 @default.
- W4322769904 cites W3174453645 @default.
- W4322769904 cites W3194423298 @default.
- W4322769904 cites W3197002293 @default.
- W4322769904 cites W3198130746 @default.
- W4322769904 cites W3209537235 @default.
- W4322769904 cites W4200352881 @default.
- W4322769904 cites W4224022793 @default.
- W4322769904 cites W4250581107 @default.
- W4322769904 cites W4283074565 @default.
- W4322769904 cites W4286592368 @default.
- W4322769904 cites W4289925328 @default.
- W4322769904 cites W4289935818 @default.
- W4322769904 cites W4290085767 @default.
- W4322769904 cites W4303645052 @default.
- W4322769904 cites W4303961883 @default.
- W4322769904 cites W4312196322 @default.
- W4322769904 cites W4316038800 @default.
- W4322769904 cites W4321458616 @default.
- W4322769904 cites W79815117 @default.