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• W4322770996 abstract "Genital melanocytic lesions can be quite difficult to distinguish due to the close proximity of the clinical findings. Melanocytic lesions, especially in delicate anatomical locations such as the vulva, penis, mons pubis etc, are even more challenging to diagnose. The patients may delay physical examinations due to anxiety or discomfort from the location of the lesion. In terms of therapy options, the surgical approach is not always the preferred one, but it is the one that could lead to a definitive solution to the problem. A limited number of studies in the medical literature do not exclude the fact that atypical nevi of genital type could also be considered as melanoma precursors. Single case reports have identified atypical genital nevi of the labia majora as a risk factor for genital melanoma development. Lesions that occupy a larger area than the labia majora and extend into the areas around them are particularly problematic. Precisely because of this fact, the result of a single biopsy could be false and misleading. Therefore, careful physical and repeated preoperative histological examinations are mandatory. Mechanical irritation in the genital area, and in particular in the labia majora region, is an additional reason for choosing the surgical-reconstructive therapeutic option. We present a 13-year-old female with a progressive “kissing” divided nevus from genital type (AMNGT) , located in the area of the vulva and labia majora, extending to the mucosa. A biopsy was taken in order to rule out malignancy. Immunohistochemistry was performed with specific melanocyte markers S-100, HMB-45 and SOX confirming the benign origin of the lesion. A diagnosis of atypical melanocytic nevus of genital type (AMNGT) was made. For prevention a surgical excision was advised but later on declined by the patient’s parents. Further close observation of the lesion was recommended." @default.
• W4322770996 created "2023-03-03" @default.
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• W4322770996 date "2023-03-02" @default.
• W4322770996 modified "2023-10-01" @default.
• W4322770996 title "Kissing atypical genital Nevus (AMNGT) of the labia majora in a young Bulgarian patient: Whats the best?" @default.
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• W4322770996 doi "https://doi.org/10.4081/dr.2023.9667" @default.
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