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• W4322772811 abstract "Bone remodeling is regulated by the interaction between different cells and tissues across many spatial and temporal scales. Notably, in silico models are regarded as powerful tools to further understand the signaling pathways that regulate this intricate spatial cellular interplay. To this end, we have established a 3D multiscale micro-multiphysics agent-based (micro-MPA) in silico model of trabecular bone remodeling using longitudinal in vivo data from the sixth caudal vertebra (CV6) of PolgA (D257A/D257A) mice, a mouse model of premature aging. Our in silico model includes a variety of cells as single agents and receptor-ligand kinetics, mechanomics, diffusion and decay of cytokines which regulate the cells’ behavior. We highlighted its capabilities by simulating trabecular bone remodeling in the CV6 of five mice over 4 weeks and we evaluated the static and dynamic morphometry of the trabecular bone microarchitecture. Based on the progression of the average trabecular bone volume fraction (BV/TV), we identified a configuration of the model parameters to simulate homeostatic trabecular bone remodeling, here named basal. Crucially, we also produced anabolic, anti-anabolic, catabolic and anti-catabolic responses with an increase or decrease by one standard deviation in the levels of osteoprotegerin (OPG), receptor activator of nuclear factor kB ligand (RANKL), and sclerostin (Scl) produced by the osteocytes. Our results showed that changes in the levels of OPG and RANKL were positively and negatively correlated with the BV/TV values after 4 weeks in comparison to basal levels, respectively. Conversely, changes in Scl levels produced small fluctuations in BV/TV in comparison to the basal state. From these results, Scl was deemed to be the main driver of equilibrium while RANKL and OPG were shown to be involved in changes in bone volume fraction with potential relevance for age-related bone features. Ultimately, this micro-MPA model provides valuable insights into how cells respond to their local mechanical environment and can help to identify critical pathways affected by degenerative conditions and ageing." @default.
• W4322772811 created "2023-03-03" @default.
• W4322772811 creator A5019976903 @default.
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• W4322772811 date "2023-03-02" @default.
• W4322772811 modified "2023-10-05" @default.
• W4322772811 title "Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics" @default.
• W4322772811 cites W1589662636 @default.
• W4322772811 cites W1757602702 @default.
• W4322772811 cites W1777589518 @default.
• W4322772811 cites W1938637920 @default.
• W4322772811 cites W1964733232 @default.
• W4322772811 cites W1970144926 @default.
• W4322772811 cites W1975953388 @default.
• W4322772811 cites W1982187195 @default.
• W4322772811 cites W1982395713 @default.
• W4322772811 cites W1985227590 @default.
• W4322772811 cites W1996161852 @default.
• W4322772811 cites W2001032894 @default.
• W4322772811 cites W2001808739 @default.
• W4322772811 cites W2003081219 @default.
• W4322772811 cites W2004354707 @default.
• W4322772811 cites W2010617850 @default.
• W4322772811 cites W2011494353 @default.
• W4322772811 cites W2012697645 @default.
• W4322772811 cites W2013293643 @default.
• W4322772811 cites W2022121540 @default.
• W4322772811 cites W2028018890 @default.
• W4322772811 cites W2028065902 @default.
• W4322772811 cites W2032394856 @default.
• W4322772811 cites W2043991983 @default.
• W4322772811 cites W2044897807 @default.
• W4322772811 cites W2049161806 @default.
• W4322772811 cites W2054531168 @default.
• W4322772811 cites W2056442040 @default.
• W4322772811 cites W2068916684 @default.
• W4322772811 cites W2073878227 @default.
• W4322772811 cites W2085047658 @default.
• W4322772811 cites W2087560312 @default.
• W4322772811 cites W2097749765 @default.
• W4322772811 cites W2104889685 @default.
• W4322772811 cites W2108403721 @default.
• W4322772811 cites W2113523811 @default.
• W4322772811 cites W2119962765 @default.
• W4322772811 cites W2121174953 @default.
• W4322772811 cites W2122907545 @default.
• W4322772811 cites W2133449428 @default.
• W4322772811 cites W2135671879 @default.
• W4322772811 cites W2135972368 @default.
• W4322772811 cites W2142838865 @default.
• W4322772811 cites W2148851290 @default.
• W4322772811 cites W2153029275 @default.
• W4322772811 cites W2195625763 @default.
• W4322772811 cites W2241584074 @default.
• W4322772811 cites W2274492504 @default.
• W4322772811 cites W2572645650 @default.
• W4322772811 cites W2768761057 @default.
• W4322772811 cites W2774486220 @default.
• W4322772811 cites W2946816687 @default.
• W4322772811 cites W2952698168 @default.
• W4322772811 cites W2979658887 @default.
• W4322772811 cites W2982618177 @default.
• W4322772811 cites W2991179912 @default.
• W4322772811 cites W2999277489 @default.
• W4322772811 cites W3037987622 @default.
• W4322772811 cites W3043814793 @default.
• W4322772811 cites W3084164734 @default.
• W4322772811 cites W3088689133 @default.
• W4322772811 cites W3094861813 @default.
• W4322772811 cites W3098281632 @default.
• W4322772811 cites W3098646193 @default.
• W4322772811 cites W3111952893 @default.
• W4322772811 cites W3136945091 @default.
• W4322772811 cites W3142448953 @default.
• W4322772811 cites W3164857664 @default.
• W4322772811 cites W3165635859 @default.
• W4322772811 cites W3197018812 @default.
• W4322772811 cites W3209961070 @default.
• W4322772811 cites W4223628801 @default.
• W4322772811 cites W4292787268 @default.
• W4322772811 cites W4293567789 @default.
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• W4322772811 doi "https://doi.org/10.3389/fbioe.2023.1091294" @default.
• W4322772811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36937760" @default.
• W4322772811 hasPublicationYear "2023" @default.
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