Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322775905> ?p ?o ?g. }
- W4322775905 endingPage "1092.e9" @default.
- W4322775905 startingPage "1075" @default.
- W4322775905 abstract "A multitude of histone chaperones are required to support histones from their biosynthesis until DNA deposition. They cooperate through the formation of histone co-chaperone complexes, but the crosstalk between nucleosome assembly pathways remains enigmatic. Using exploratory interactomics, we define the interplay between human histone H3-H4 chaperones in the histone chaperone network. We identify previously uncharacterized histone-dependent complexes and predict the structure of the ASF1 and SPT2 co-chaperone complex, expanding the role of ASF1 in histone dynamics. We show that DAXX provides a unique functionality to the histone chaperone network, recruiting histone methyltransferases to promote H3K9me3 catalysis on new histone H3.3-H4 prior to deposition onto DNA. Hereby, DAXX provides a molecular mechanism for de novo H3K9me3 deposition and heterochromatin assembly. Collectively, our findings provide a framework for understanding how cells orchestrate histone supply and employ targeted deposition of modified histones to underpin specialized chromatin states." @default.
- W4322775905 created "2023-03-03" @default.
- W4322775905 creator A5002789694 @default.
- W4322775905 creator A5010964793 @default.
- W4322775905 creator A5017461128 @default.
- W4322775905 creator A5027774844 @default.
- W4322775905 creator A5031343137 @default.
- W4322775905 creator A5050670577 @default.
- W4322775905 creator A5051185441 @default.
- W4322775905 creator A5065023489 @default.
- W4322775905 creator A5067117947 @default.
- W4322775905 creator A5076844877 @default.
- W4322775905 creator A5087145202 @default.
- W4322775905 creator A5089567310 @default.
- W4322775905 creator A5091538305 @default.
- W4322775905 date "2023-04-01" @default.
- W4322775905 modified "2023-10-15" @default.
- W4322775905 title "DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network" @default.
- W4322775905 cites W1417021171 @default.
- W4322775905 cites W1793067559 @default.
- W4322775905 cites W1920350157 @default.
- W4322775905 cites W1931686165 @default.
- W4322775905 cites W1966218941 @default.
- W4322775905 cites W1970304959 @default.
- W4322775905 cites W1970916644 @default.
- W4322775905 cites W1972029155 @default.
- W4322775905 cites W1974784924 @default.
- W4322775905 cites W1975859486 @default.
- W4322775905 cites W1976122783 @default.
- W4322775905 cites W1977087301 @default.
- W4322775905 cites W1978678628 @default.
- W4322775905 cites W1981010326 @default.
- W4322775905 cites W1981071130 @default.
- W4322775905 cites W1981700185 @default.
- W4322775905 cites W1983859430 @default.
- W4322775905 cites W1989915311 @default.
- W4322775905 cites W1991366673 @default.
- W4322775905 cites W1994158526 @default.
- W4322775905 cites W2003236418 @default.
- W4322775905 cites W2010817679 @default.
- W4322775905 cites W2012025493 @default.
- W4322775905 cites W2022267672 @default.
- W4322775905 cites W2029087061 @default.
- W4322775905 cites W2032467048 @default.
- W4322775905 cites W2035515342 @default.
- W4322775905 cites W2040904248 @default.
- W4322775905 cites W2042239071 @default.
- W4322775905 cites W2047795717 @default.
- W4322775905 cites W2047820533 @default.
- W4322775905 cites W2047881988 @default.
- W4322775905 cites W2053330747 @default.
- W4322775905 cites W2054589275 @default.
- W4322775905 cites W2058434102 @default.
- W4322775905 cites W2059369082 @default.
- W4322775905 cites W2070367241 @default.
- W4322775905 cites W2070994087 @default.
- W4322775905 cites W2080089210 @default.
- W4322775905 cites W2080571195 @default.
- W4322775905 cites W2080578479 @default.
- W4322775905 cites W2086516583 @default.
- W4322775905 cites W2088670929 @default.
- W4322775905 cites W2092213937 @default.
- W4322775905 cites W2102859326 @default.
- W4322775905 cites W2103089522 @default.
- W4322775905 cites W2105617035 @default.
- W4322775905 cites W2108088228 @default.
- W4322775905 cites W2112445327 @default.
- W4322775905 cites W2117568376 @default.
- W4322775905 cites W2126451754 @default.
- W4322775905 cites W2129068490 @default.
- W4322775905 cites W2131633518 @default.
- W4322775905 cites W2132232570 @default.
- W4322775905 cites W2132316576 @default.
- W4322775905 cites W2144792857 @default.
- W4322775905 cites W2145467073 @default.
- W4322775905 cites W2151026121 @default.
- W4322775905 cites W2151243552 @default.
- W4322775905 cites W2153653183 @default.
- W4322775905 cites W2156134501 @default.
- W4322775905 cites W2159079025 @default.
- W4322775905 cites W2159450566 @default.
- W4322775905 cites W2168146428 @default.
- W4322775905 cites W2170776626 @default.
- W4322775905 cites W2171967738 @default.
- W4322775905 cites W2172454326 @default.
- W4322775905 cites W2178357398 @default.
- W4322775905 cites W2272774995 @default.
- W4322775905 cites W2320510676 @default.
- W4322775905 cites W2324719756 @default.
- W4322775905 cites W2338045966 @default.
- W4322775905 cites W2473363865 @default.
- W4322775905 cites W2528248328 @default.
- W4322775905 cites W2567956911 @default.
- W4322775905 cites W2570296944 @default.
- W4322775905 cites W2587723625 @default.
- W4322775905 cites W2598221142 @default.
- W4322775905 cites W2618569629 @default.
- W4322775905 cites W2619566212 @default.