FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323031012> ?p ?o ?g. }

• W4323031012 endingPage "114371" @default.
• W4323031012 startingPage "114371" @default.
• W4323031012 abstract "Alzheimer's disease (AD) is closely related to hippocampal synapse loss, which can be alleviated by running exercise. However, further studies are needed to determine whether running exercise reduces synapse loss in the hippocampus in an AD model by regulating microglia. Ten-month-old male wild-type mice and APP/PS1 mice were randomly divided into control and running groups. All mice in the running groups were subjected to voluntary running exercise for four months. After the behavioral tests, immunohistochemistry, stereological methods, immunofluorescence staining, 3D reconstruction, western blotting and RNA-Seq were performed. Running exercise improved the spatial learning and memory abilities of APP/PS1 mice and increased the total number of dendritic spines, the levels of the PSD-95 and Synapsin Ia/b proteins, the colocalization of PSD-95 and neuronal dendrites (MAP-2) and the number of PSD-95-contacting astrocytes (GFAP) in the hippocampi of APP/PS1 mice. Moreover, running exercise reduced the relative expression of CD68 and Iba-1, the number of Iba-1+ microglia and the colocalization of PSD-95 and Iba-1+ microglia in the hippocampi of APP/PS1 mice. The RNA-Seq results showed that some differentially expressed genes (DEGs) related to the complement system (Cd59b, Serping1, Cfh, A2m, and Trem2) were upregulated in the hippocampi of APP/PS1 mice, while running exercise downregulated the C3 gene. At the protein level, running exercise also reduced the expression of advanced glycation end products (AGEs), receptor for advanced glycation end products (RAGE), C1q and C3 in the hippocampus and AGEs and RAGE in hippocampal microglia in APP/PS1 mice. Furthermore, the Col6a3, Scn5a, Cxcl5, Tdg and Clec4n genes were upregulated in the hippocampi of APP/PS1 mice but downregulated after running, and these genes were associated with the C3 and RAGE genes according to protein-protein interaction (PPI) analysis. These findings indicate that long-term voluntary exercise might protect hippocampal synapses and affect the function and activation of microglia, the AGE/RAGE signaling pathway in microglia and the C1q/C3 complement system in the hippocampus in APP/PS1 mice, and these effects may be related to the Col6a3, Scn5a, Cxcl5, Tdg and Clec4n genes. The current results provide an important basis for identifying targets for the prevention and treatment of AD." @default.
• W4323031012 created "2023-03-04" @default.
• W4323031012 creator A5004614278 @default.
• W4323031012 creator A5031499311 @default.
• W4323031012 creator A5037391254 @default.
• W4323031012 creator A5055364186 @default.
• W4323031012 creator A5058481549 @default.
• W4323031012 creator A5059276823 @default.
• W4323031012 creator A5060010401 @default.
• W4323031012 creator A5060141911 @default.
• W4323031012 creator A5063481044 @default.
• W4323031012 creator A5066213432 @default.
• W4323031012 creator A5077066775 @default.
• W4323031012 creator A5077210762 @default.
• W4323031012 creator A5077227452 @default.
• W4323031012 creator A5082185821 @default.
• W4323031012 date "2023-05-01" @default.
• W4323031012 modified "2023-10-15" @default.
• W4323031012 title "Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice" @default.
• W4323031012 cites W1456373634 @default.
• W4323031012 cites W1487695731 @default.
• W4323031012 cites W1531365070 @default.
• W4323031012 cites W1575154149 @default.
• W4323031012 cites W1584384737 @default.
• W4323031012 cites W1853959720 @default.
• W4323031012 cites W1876773427 @default.
• W4323031012 cites W1915977580 @default.
• W4323031012 cites W1964945625 @default.
• W4323031012 cites W1967464880 @default.
• W4323031012 cites W1967794631 @default.
• W4323031012 cites W1976296246 @default.
• W4323031012 cites W1980789245 @default.
• W4323031012 cites W1984325684 @default.
• W4323031012 cites W1984652813 @default.
• W4323031012 cites W1985623947 @default.
• W4323031012 cites W1986677236 @default.
• W4323031012 cites W1989605260 @default.
• W4323031012 cites W1990293508 @default.
• W4323031012 cites W1990483753 @default.
• W4323031012 cites W1993465897 @default.
• W4323031012 cites W1996981671 @default.
• W4323031012 cites W1999769601 @default.
• W4323031012 cites W2003813921 @default.
• W4323031012 cites W2007818439 @default.
• W4323031012 cites W2008986992 @default.
• W4323031012 cites W2020951538 @default.
• W4323031012 cites W2030004690 @default.
• W4323031012 cites W2033302498 @default.
• W4323031012 cites W2033617297 @default.
• W4323031012 cites W2039550203 @default.
• W4323031012 cites W2046801118 @default.
• W4323031012 cites W2056313099 @default.
• W4323031012 cites W2056787227 @default.
• W4323031012 cites W2058409428 @default.
• W4323031012 cites W2060995405 @default.
• W4323031012 cites W2063987862 @default.
• W4323031012 cites W2066116456 @default.
• W4323031012 cites W2069498125 @default.
• W4323031012 cites W2073809598 @default.
• W4323031012 cites W2085293170 @default.
• W4323031012 cites W2088780441 @default.
• W4323031012 cites W2098533587 @default.
• W4323031012 cites W2111405228 @default.
• W4323031012 cites W2111570868 @default.
• W4323031012 cites W2121428135 @default.
• W4323031012 cites W2122743846 @default.
• W4323031012 cites W2122779261 @default.
• W4323031012 cites W2138541585 @default.
• W4323031012 cites W2142514276 @default.
• W4323031012 cites W2149879510 @default.
• W4323031012 cites W2153184101 @default.
• W4323031012 cites W2158805435 @default.
• W4323031012 cites W2159579257 @default.
• W4323031012 cites W2163691580 @default.
• W4323031012 cites W2164133449 @default.
• W4323031012 cites W2165302236 @default.
• W4323031012 cites W2177834950 @default.
• W4323031012 cites W2193466021 @default.
• W4323031012 cites W2280077905 @default.
• W4323031012 cites W2307398552 @default.
• W4323031012 cites W2471328253 @default.
• W4323031012 cites W2471701648 @default.
• W4323031012 cites W2509907732 @default.
• W4323031012 cites W2532659719 @default.
• W4323031012 cites W2568320657 @default.
• W4323031012 cites W2587891766 @default.
• W4323031012 cites W2588124790 @default.
• W4323031012 cites W2605483677 @default.
• W4323031012 cites W2607050832 @default.
• W4323031012 cites W2609860042 @default.
• W4323031012 cites W2613240073 @default.
• W4323031012 cites W2614586381 @default.
• W4323031012 cites W2618794795 @default.
• W4323031012 cites W2620082173 @default.
• W4323031012 cites W2753593979 @default.
• W4323031012 cites W2755806383 @default.
• W4323031012 cites W2768580979 @default.
• W4323031012 cites W2774947569 @default.

• next