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- W4323032859 abstract "Both innate and adaptive immune system undergo evolution from low to high vertebrates. Due to the limitation of conventional approaches in identifying broader spectrum of immune cells and molecules from various vertebrates, it remains unclear how immune molecules evolve among vertebrates. Here, we utilized carry out comparative transcriptome analysis in various immune cells across seven vertebrate species. Single-cell RNA sequencing (scRNA-seq). We uncovered both conserved and species-specific profiling of gene expression in innate and adaptive immunity. Macrophages exhibited highly-diversified genes and developed sophisticated molecular signaling networks along with evolution, indicating effective and versatile functions in higher species. In contrast, B cells conservatively evolved with less differentially-expressed genes in analyzed species. Interestingly, T cells represented a dominant immune cell populations in all species and unique T cell populations were identified in zebrafish and pig. We also revealed compensatory TCR cascade components utilized by different species. Inter-species comparison of core gene programs demonstrated mouse species has the highest similarity in immune transcriptomes to human. Therefore, our comparative study reveals gene transcription characteristics across multiple vertebrate species during the evolution of immune system, providing insights for species-specific immunity as well as the translation of animal studies to human physiology and disease." @default.
- W4323032859 created "2023-03-04" @default.
- W4323032859 creator A5001162052 @default.
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- W4323032859 date "2023-03-01" @default.
- W4323032859 modified "2023-10-18" @default.
- W4323032859 title "Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species" @default.
- W4323032859 cites W1487897082 @default.
- W4323032859 cites W1518095394 @default.
- W4323032859 cites W1689369637 @default.
- W4323032859 cites W1698396880 @default.
- W4323032859 cites W1801353699 @default.
- W4323032859 cites W1918638041 @default.
- W4323032859 cites W1927992572 @default.
- W4323032859 cites W1952540413 @default.
- W4323032859 cites W1968191137 @default.
- W4323032859 cites W1972489295 @default.
- W4323032859 cites W1972517114 @default.
- W4323032859 cites W1979055719 @default.
- W4323032859 cites W1979387940 @default.
- W4323032859 cites W1979554951 @default.
- W4323032859 cites W1981160000 @default.
- W4323032859 cites W1989708237 @default.
- W4323032859 cites W1991543373 @default.
- W4323032859 cites W1995744610 @default.
- W4323032859 cites W2004165973 @default.
- W4323032859 cites W2007050309 @default.
- W4323032859 cites W2020969300 @default.
- W4323032859 cites W2023143826 @default.
- W4323032859 cites W2023941836 @default.
- W4323032859 cites W2029531805 @default.
- W4323032859 cites W2032760168 @default.
- W4323032859 cites W2033560950 @default.
- W4323032859 cites W2035618305 @default.
- W4323032859 cites W2040668262 @default.
- W4323032859 cites W2050040190 @default.
- W4323032859 cites W2054542448 @default.
- W4323032859 cites W2064993419 @default.
- W4323032859 cites W2069957135 @default.
- W4323032859 cites W2073118744 @default.
- W4323032859 cites W2073745127 @default.
- W4323032859 cites W2077290438 @default.
- W4323032859 cites W2090945841 @default.
- W4323032859 cites W2093626188 @default.
- W4323032859 cites W2100363448 @default.
- W4323032859 cites W2103804401 @default.
- W4323032859 cites W2106391842 @default.
- W4323032859 cites W2123335694 @default.
- W4323032859 cites W2138651252 @default.
- W4323032859 cites W2146122014 @default.
- W4323032859 cites W2146341019 @default.
- W4323032859 cites W2154938671 @default.
- W4323032859 cites W2158313944 @default.
- W4323032859 cites W2159675211 @default.
- W4323032859 cites W2160520579 @default.
- W4323032859 cites W2191880222 @default.
- W4323032859 cites W2406250479 @default.
- W4323032859 cites W2408766557 @default.
- W4323032859 cites W2518536270 @default.
- W4323032859 cites W2591655768 @default.
- W4323032859 cites W2753518299 @default.
- W4323032859 cites W2790505494 @default.
- W4323032859 cites W2794480084 @default.
- W4323032859 cites W2803300773 @default.
- W4323032859 cites W2894687190 @default.
- W4323032859 cites W2901405427 @default.
- W4323032859 cites W2914913137 @default.
- W4323032859 cites W2918621261 @default.
- W4323032859 cites W2937950890 @default.
- W4323032859 cites W2948911456 @default.
- W4323032859 cites W2949177718 @default.
- W4323032859 cites W2955084980 @default.
- W4323032859 cites W2969593942 @default.
- W4323032859 cites W2973312406 @default.
- W4323032859 cites W2990889969 @default.
- W4323032859 cites W2991313606 @default.
- W4323032859 cites W3000676906 @default.
- W4323032859 cites W3004268891 @default.
- W4323032859 cites W3011242662 @default.
- W4323032859 cites W3023126733 @default.
- W4323032859 cites W3025179027 @default.
- W4323032859 cites W3031553816 @default.
- W4323032859 cites W3048076282 @default.
- W4323032859 cites W3091872297 @default.
- W4323032859 cites W3112976705 @default.
- W4323032859 cites W3177161004 @default.