FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323035553> ?p ?o ?g. }

• W4323035553 endingPage "315" @default.
• W4323035553 startingPage "304" @default.
• W4323035553 abstract "Medicinal properties of curcumin are widely published. Previously, researchers used curcuminoid mixture comprising three chemical forms, out of which, the highest quantity is the most active molecule-dimethoxy curcumin (DMC). Reduced bioavailability, poor aqueous solubility, and quick hydrolytic degradation of DMC have projected challenges limiting its therapeutic value. However, selective conjugation of DMC with human serum albumin (HSA) enhances drug stability and solubility by several folds. Studies using animal models demonstrated potential anti-cancer/anti-inflammatory effects of DMCHSA; both studies showed results of local administration in peritoneal cavity and rabbit knee joint. DMC has prospects as intravenous therapeutic agent because carrier is HSA. However, before in vivo testing, important preclinical data required are toxicological safety and bioavailability of soluble forms of DMC. This study evaluated absorption, distribution, metabolism, and excretion of DMCHSA. Imaging technology and molecular analysis proved bio-distribution. The study also assessed the pharmacological safety of DMCHSA in mice in terms of its acute and sub-acute toxicity, complying with regulatory toxicology. Overall, the study demonstrated the safety pharmacology of DMCHSA upon intravenous infusion. This is a novel study establishing the safety of highly soluble and stable formulation of DMCHSA, qualifying it for intravenous administration and further efficacy evaluation in suitable disease models." @default.
• W4323035553 created "2023-03-04" @default.
• W4323035553 creator A5007886442 @default.
• W4323035553 creator A5010788792 @default.
• W4323035553 creator A5023323470 @default.
• W4323035553 creator A5029765745 @default.
• W4323035553 creator A5046024573 @default.
• W4323035553 creator A5048334239 @default.
• W4323035553 creator A5076074790 @default.
• W4323035553 date "2023-06-01" @default.
• W4323035553 modified "2023-09-27" @default.
• W4323035553 title "Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose" @default.
• W4323035553 cites W1975090882 @default.
• W4323035553 cites W1978223966 @default.
• W4323035553 cites W1979734999 @default.
• W4323035553 cites W1985342300 @default.
• W4323035553 cites W1987712541 @default.
• W4323035553 cites W1990870506 @default.
• W4323035553 cites W2013585426 @default.
• W4323035553 cites W2020055240 @default.
• W4323035553 cites W2022290696 @default.
• W4323035553 cites W2026768166 @default.
• W4323035553 cites W2030711777 @default.
• W4323035553 cites W2038796248 @default.
• W4323035553 cites W2041764058 @default.
• W4323035553 cites W2048604010 @default.
• W4323035553 cites W2051802223 @default.
• W4323035553 cites W2056638689 @default.
• W4323035553 cites W2063293300 @default.
• W4323035553 cites W2071477176 @default.
• W4323035553 cites W2071965500 @default.
• W4323035553 cites W2080556420 @default.
• W4323035553 cites W2100880117 @default.
• W4323035553 cites W2130751640 @default.
• W4323035553 cites W2142201529 @default.
• W4323035553 cites W2158735110 @default.
• W4323035553 cites W2178801398 @default.
• W4323035553 cites W2282552839 @default.
• W4323035553 cites W2411457407 @default.
• W4323035553 cites W2433713077 @default.
• W4323035553 cites W2507263359 @default.
• W4323035553 cites W2519838368 @default.
• W4323035553 cites W2766083858 @default.
• W4323035553 cites W2787220856 @default.
• W4323035553 cites W2789343877 @default.
• W4323035553 cites W2940436383 @default.
• W4323035553 cites W2941776018 @default.
• W4323035553 cites W3034903248 @default.
• W4323035553 cites W3117090837 @default.
• W4323035553 cites W3122388469 @default.
• W4323035553 cites W3173269646 @default.
• W4323035553 cites W3178003350 @default.
• W4323035553 cites W4212766898 @default.
• W4323035553 cites W4226453130 @default.
• W4323035553 cites W4237769455 @default.
• W4323035553 cites W4247050267 @default.
• W4323035553 cites W4301807412 @default.
• W4323035553 doi "https://doi.org/10.1139/cjpp-2022-0408" @default.
• W4323035553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36867858" @default.
• W4323035553 hasPublicationYear "2023" @default.
• W4323035553 type Work @default.
• W4323035553 citedByCount "0" @default.
• W4323035553 crossrefType "journal-article" @default.
• W4323035553 hasAuthorship W4323035553A5007886442 @default.
• W4323035553 hasAuthorship W4323035553A5010788792 @default.
• W4323035553 hasAuthorship W4323035553A5023323470 @default.
• W4323035553 hasAuthorship W4323035553A5029765745 @default.
• W4323035553 hasAuthorship W4323035553A5046024573 @default.
• W4323035553 hasAuthorship W4323035553A5048334239 @default.
• W4323035553 hasAuthorship W4323035553A5076074790 @default.
• W4323035553 hasConcept C112705442 @default.
• W4323035553 hasConcept C126322002 @default.
• W4323035553 hasConcept C150903083 @default.
• W4323035553 hasConcept C181389837 @default.
• W4323035553 hasConcept C185592680 @default.
• W4323035553 hasConcept C19831878 @default.
• W4323035553 hasConcept C207001950 @default.
• W4323035553 hasConcept C2778250585 @default.
• W4323035553 hasConcept C2778597219 @default.
• W4323035553 hasConcept C2780035454 @default.
• W4323035553 hasConcept C29730261 @default.
• W4323035553 hasConcept C55493867 @default.
• W4323035553 hasConcept C69366308 @default.
• W4323035553 hasConcept C71924100 @default.
• W4323035553 hasConcept C86803240 @default.
• W4323035553 hasConcept C98274493 @default.
• W4323035553 hasConceptScore W4323035553C112705442 @default.
• W4323035553 hasConceptScore W4323035553C126322002 @default.
• W4323035553 hasConceptScore W4323035553C150903083 @default.
• W4323035553 hasConceptScore W4323035553C181389837 @default.
• W4323035553 hasConceptScore W4323035553C185592680 @default.
• W4323035553 hasConceptScore W4323035553C19831878 @default.
• W4323035553 hasConceptScore W4323035553C207001950 @default.
• W4323035553 hasConceptScore W4323035553C2778250585 @default.
• W4323035553 hasConceptScore W4323035553C2778597219 @default.
• W4323035553 hasConceptScore W4323035553C2780035454 @default.
• W4323035553 hasConceptScore W4323035553C29730261 @default.
• W4323035553 hasConceptScore W4323035553C55493867 @default.

• next