Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323036481> ?p ?o ?g. }
- W4323036481 endingPage "1881" @default.
- W4323036481 startingPage "1871" @default.
- W4323036481 abstract "Abstract Hypercholesterolemia is associated with tendon pathology and injury prevalence. Lipids can accumulate in the tendon's extracellular spaces, which may disrupt its hierarchical structure and the tenocytes physicochemical environment. We hypothesized that the tendon's ability to repair after injury would be attenuated with elevated cholesterol levels, leading to inferior mechanical properties. Fifty wild‐type (sSD) and 50 apolipoprotein E knock‐out rats ( ApoE −/ − ) were given a unilateral patellar tendon (PT) injury at 12 weeks old; the uninjured limb served as a control. Animals were euthanized at 3‐, 14,‐ or 42‐days postinjury and PT healing was investigated. ApoE −/ − serum cholesterol was double that of SD rats (mean: 2.12 vs. 0.99 mg/mL, p < 0.001) and cholesterol level was related to the expression of several genes after injury; notably rats with higher cholesterol demonstrated a blunted inflammatory response. There was little physical evidence of tendon lipid content or differences in injury repair between groups, therefore we were not surprised that tendon mechanical or material properties did not differ between strains. The young age and the mild phenotype of our ApoE −/ − rats might explain these findings. Hydroxyproline content was positively related to total blood cholesterol, but this result did not translate to observable biomechanical differences, perhaps due to the narrow range of cholesterol levels observed. Tendon inflammatory and healing activity is modulated at the mRNA level even with a mild hypercholesterolemia. These important initial impacts need to be investigated as they may contribute to the known consequences of cholesterol on tendons in humans." @default.
- W4323036481 created "2023-03-04" @default.
- W4323036481 creator A5000122955 @default.
- W4323036481 creator A5022035980 @default.
- W4323036481 creator A5022043047 @default.
- W4323036481 creator A5036914597 @default.
- W4323036481 creator A5074095862 @default.
- W4323036481 date "2023-03-20" @default.
- W4323036481 modified "2023-09-26" @default.
- W4323036481 title "The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon" @default.
- W4323036481 cites W1603414617 @default.
- W4323036481 cites W1667085792 @default.
- W4323036481 cites W1757841311 @default.
- W4323036481 cites W1952062893 @default.
- W4323036481 cites W1965508158 @default.
- W4323036481 cites W1988904306 @default.
- W4323036481 cites W1994105417 @default.
- W4323036481 cites W2002241228 @default.
- W4323036481 cites W2011943209 @default.
- W4323036481 cites W2016263786 @default.
- W4323036481 cites W2026401175 @default.
- W4323036481 cites W2029167264 @default.
- W4323036481 cites W2029935659 @default.
- W4323036481 cites W2046696056 @default.
- W4323036481 cites W2052672622 @default.
- W4323036481 cites W2068174131 @default.
- W4323036481 cites W2080338162 @default.
- W4323036481 cites W2082794658 @default.
- W4323036481 cites W2085069678 @default.
- W4323036481 cites W2096363956 @default.
- W4323036481 cites W2104460754 @default.
- W4323036481 cites W2104935090 @default.
- W4323036481 cites W2113186517 @default.
- W4323036481 cites W2115371480 @default.
- W4323036481 cites W2141632196 @default.
- W4323036481 cites W2144863994 @default.
- W4323036481 cites W2145753147 @default.
- W4323036481 cites W2145778415 @default.
- W4323036481 cites W2166458609 @default.
- W4323036481 cites W2166648746 @default.
- W4323036481 cites W2169999371 @default.
- W4323036481 cites W2194180664 @default.
- W4323036481 cites W2279862511 @default.
- W4323036481 cites W2513502292 @default.
- W4323036481 cites W2572367037 @default.
- W4323036481 cites W2593456141 @default.
- W4323036481 cites W2805846806 @default.
- W4323036481 cites W2895810712 @default.
- W4323036481 cites W2905567699 @default.
- W4323036481 cites W2944617715 @default.
- W4323036481 cites W2950545112 @default.
- W4323036481 cites W2951092628 @default.
- W4323036481 cites W2995144570 @default.
- W4323036481 cites W3028800184 @default.
- W4323036481 cites W3033499384 @default.
- W4323036481 cites W3037357689 @default.
- W4323036481 cites W3043135743 @default.
- W4323036481 cites W3110951804 @default.
- W4323036481 cites W3201484255 @default.
- W4323036481 cites W575506117 @default.
- W4323036481 doi "https://doi.org/10.1002/jor.25546" @default.
- W4323036481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36866829" @default.
- W4323036481 hasPublicationYear "2023" @default.
- W4323036481 type Work @default.
- W4323036481 citedByCount "1" @default.
- W4323036481 countsByYear W43230364812023 @default.
- W4323036481 crossrefType "journal-article" @default.
- W4323036481 hasAuthorship W4323036481A5000122955 @default.
- W4323036481 hasAuthorship W4323036481A5022035980 @default.
- W4323036481 hasAuthorship W4323036481A5022043047 @default.
- W4323036481 hasAuthorship W4323036481A5036914597 @default.
- W4323036481 hasAuthorship W4323036481A5074095862 @default.
- W4323036481 hasBestOaLocation W43230364811 @default.
- W4323036481 hasConcept C126322002 @default.
- W4323036481 hasConcept C134018914 @default.
- W4323036481 hasConcept C141071460 @default.
- W4323036481 hasConcept C142724271 @default.
- W4323036481 hasConcept C2778163477 @default.
- W4323036481 hasConcept C2779134260 @default.
- W4323036481 hasConcept C2779797417 @default.
- W4323036481 hasConcept C2780105995 @default.
- W4323036481 hasConcept C2991944018 @default.
- W4323036481 hasConcept C57089818 @default.
- W4323036481 hasConcept C62746215 @default.
- W4323036481 hasConcept C71924100 @default.
- W4323036481 hasConceptScore W4323036481C126322002 @default.
- W4323036481 hasConceptScore W4323036481C134018914 @default.
- W4323036481 hasConceptScore W4323036481C141071460 @default.
- W4323036481 hasConceptScore W4323036481C142724271 @default.
- W4323036481 hasConceptScore W4323036481C2778163477 @default.
- W4323036481 hasConceptScore W4323036481C2779134260 @default.
- W4323036481 hasConceptScore W4323036481C2779797417 @default.
- W4323036481 hasConceptScore W4323036481C2780105995 @default.
- W4323036481 hasConceptScore W4323036481C2991944018 @default.
- W4323036481 hasConceptScore W4323036481C57089818 @default.
- W4323036481 hasConceptScore W4323036481C62746215 @default.
- W4323036481 hasConceptScore W4323036481C71924100 @default.
- W4323036481 hasFunder F4320334506 @default.