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- W4323038272 abstract "ABSTRACT Mammalian axons are specialized for transmitting action potentials to targets within the central and peripheral nervous system. A growing body of evidence suggests that, besides signal conduction, axons play essential roles in neural information processing, and their malfunctions are common hallmarks of neurodegenerative diseases. The technologies available to study axonal function and structure integrally limit the comprehension of axon neurobiology. High-density microelectrode arrays (HD-MEAs) allow for accessing axonal action potentials at high spatiotemporal resolution, but provide no insights on axonal morphology. Here we demonstrate a method for electrical visualization of axonal morphologies based on extracellular action potentials recorded from cortical and motor neurons using HD-MEAs. The method enabled us to reconstruct up to 5-centimeter-long axonal arbors and directly monitor axonal conduction across thousands of recording sites. We reconstructed 1.86 meters of cortical and spinal axons in total and found specific features in their structure and function." @default.
- W4323038272 created "2023-03-04" @default.
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- W4323038272 date "2023-03-01" @default.
- W4323038272 modified "2023-09-30" @default.
- W4323038272 title "Functional imaging of conduction dynamics in cortical and spinal axons" @default.
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- W4323038272 doi "https://doi.org/10.1101/2023.02.28.530461" @default.
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