Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323040315> ?p ?o ?g. }
- W4323040315 endingPage "107" @default.
- W4323040315 startingPage "99" @default.
- W4323040315 abstract "The review article analyzes the data accumulated in the literature on the association of Wilms’ tumor with chromosomal syndromes and searches for possible causes of this phenomenon. In 10 % of all cases, nephroblastoma is represented by a hereditary tumor syndrome due to germline mutations in suppressor genes, mainly in the WT1 gene, less often in WT2 , WTX , CTNNB1 , TP53 . These genes are associated with retroelements that play a role in the development of Wilms’ tumor, promoting carcinogenesis, causing genome instability. LINE-1 retroelement is a negative regulator of WT1 expression, while suppressor genes are characterized by suppression of retroelement activity. Part of the pathogenesis of Perlman, Beckwith-Wiedemann, WAGR, and trisomy 18 syndromes caused by germline microdeletions is the activation of retroelements that promote somatic chromosomal rearrangements, including deletions, insertions, and translocations, which are characteristic of sporadic Wilms’ tumor. Long noncoding RNAs and microRNAs are formed from retroelements during evolution or directly during the processing of their transcripts. At the same time, long noncoding RNAs affect the development of Wilms’ tumor by various mechanisms: due to the effect on ferroptosis (lncRNA AC007406.1, AC005208.1, LINC01770, DLGAP1-AS2, AP002761.4, STPG3-AS1, AC129507.1, AC234772.2, LINC02447, AC009570.1, ZBTB20-AS1 and LINC01179), Wnt/β-catenin signaling pathways (HOTAIR, MEG3), apoptosis (HAGLROS), regulation of expression of specific miRNAs (SNHG6, MEG8, XIST, SNHG16, DLEU1, CRNDE, SNHG6, DLGAP1, OSTM1-AS1, EMX2OS, H19). Analysis of the MDTE DB database revealed nephroblastoma-associated miRNAs that originate from retrotransposons. These include miR-192, -335, -378c, -562, -630, -1248. These molecules are promising for possible use in the pathogenetic treatment of Wilms’ tumor due to their effect on pathologically activated retrotransposons." @default.
- W4323040315 created "2023-03-04" @default.
- W4323040315 creator A5009918132 @default.
- W4323040315 date "2023-02-28" @default.
- W4323040315 modified "2023-10-18" @default.
- W4323040315 title "The probable role of retroelements in the development of Wilms’ tumor in chromosomal syndromes" @default.
- W4323040315 cites W1959248353 @default.
- W4323040315 cites W1984830334 @default.
- W4323040315 cites W1988448084 @default.
- W4323040315 cites W2011861577 @default.
- W4323040315 cites W2012169926 @default.
- W4323040315 cites W2012935740 @default.
- W4323040315 cites W2016265450 @default.
- W4323040315 cites W2023631770 @default.
- W4323040315 cites W2023854641 @default.
- W4323040315 cites W2024733621 @default.
- W4323040315 cites W2038402217 @default.
- W4323040315 cites W2042644193 @default.
- W4323040315 cites W2065517576 @default.
- W4323040315 cites W2078641812 @default.
- W4323040315 cites W2080604150 @default.
- W4323040315 cites W2082904471 @default.
- W4323040315 cites W2102824378 @default.
- W4323040315 cites W2107454957 @default.
- W4323040315 cites W2113371388 @default.
- W4323040315 cites W2114244323 @default.
- W4323040315 cites W2115368313 @default.
- W4323040315 cites W2140418236 @default.
- W4323040315 cites W2141605287 @default.
- W4323040315 cites W2142354712 @default.
- W4323040315 cites W2145709837 @default.
- W4323040315 cites W2160273279 @default.
- W4323040315 cites W2161664698 @default.
- W4323040315 cites W2166767983 @default.
- W4323040315 cites W2213981767 @default.
- W4323040315 cites W2326801857 @default.
- W4323040315 cites W2342523820 @default.
- W4323040315 cites W2402274042 @default.
- W4323040315 cites W2464479759 @default.
- W4323040315 cites W2519643400 @default.
- W4323040315 cites W2746135575 @default.
- W4323040315 cites W2775592059 @default.
- W4323040315 cites W2793247280 @default.
- W4323040315 cites W2796059570 @default.
- W4323040315 cites W2884919719 @default.
- W4323040315 cites W2895859366 @default.
- W4323040315 cites W2904008198 @default.
- W4323040315 cites W2909350414 @default.
- W4323040315 cites W2915964837 @default.
- W4323040315 cites W2921680432 @default.
- W4323040315 cites W2954562378 @default.
- W4323040315 cites W2962880403 @default.
- W4323040315 cites W3004660847 @default.
- W4323040315 cites W3005218670 @default.
- W4323040315 cites W3008874085 @default.
- W4323040315 cites W3011073638 @default.
- W4323040315 cites W3011130319 @default.
- W4323040315 cites W3015417484 @default.
- W4323040315 cites W3095708893 @default.
- W4323040315 cites W3111408318 @default.
- W4323040315 cites W3123615637 @default.
- W4323040315 cites W3125259328 @default.
- W4323040315 cites W3159219356 @default.
- W4323040315 cites W3197356067 @default.
- W4323040315 cites W4220971799 @default.
- W4323040315 cites W4280644404 @default.
- W4323040315 cites W4292323871 @default.
- W4323040315 cites W81456596 @default.
- W4323040315 doi "https://doi.org/10.17650/1726-9776-2022-18-4-99-107" @default.
- W4323040315 hasPublicationYear "2023" @default.
- W4323040315 type Work @default.
- W4323040315 citedByCount "0" @default.
- W4323040315 crossrefType "journal-article" @default.
- W4323040315 hasAuthorship W4323040315A5009918132 @default.
- W4323040315 hasBestOaLocation W43230403151 @default.
- W4323040315 hasConcept C104317684 @default.
- W4323040315 hasConcept C109825262 @default.
- W4323040315 hasConcept C137620995 @default.
- W4323040315 hasConcept C141231307 @default.
- W4323040315 hasConcept C145059251 @default.
- W4323040315 hasConcept C2775999222 @default.
- W4323040315 hasConcept C4918238 @default.
- W4323040315 hasConcept C502942594 @default.
- W4323040315 hasConcept C54355233 @default.
- W4323040315 hasConcept C555283112 @default.
- W4323040315 hasConcept C7029365 @default.
- W4323040315 hasConcept C86803240 @default.
- W4323040315 hasConceptScore W4323040315C104317684 @default.
- W4323040315 hasConceptScore W4323040315C109825262 @default.
- W4323040315 hasConceptScore W4323040315C137620995 @default.
- W4323040315 hasConceptScore W4323040315C141231307 @default.
- W4323040315 hasConceptScore W4323040315C145059251 @default.
- W4323040315 hasConceptScore W4323040315C2775999222 @default.
- W4323040315 hasConceptScore W4323040315C4918238 @default.
- W4323040315 hasConceptScore W4323040315C502942594 @default.
- W4323040315 hasConceptScore W4323040315C54355233 @default.
- W4323040315 hasConceptScore W4323040315C555283112 @default.
- W4323040315 hasConceptScore W4323040315C7029365 @default.