FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323046256> ?p ?o ?g. }

• W4323046256 endingPage "4899" @default.
• W4323046256 startingPage "4899" @default.
• W4323046256 abstract "Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity of tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole is a partial inhibitor of TNAP. The aim was to investigate whether lansoprazole increases plasma PPi levels in subjects with PXE. We conducted a 2 × 2 randomized, double-blind, placebo-controlled crossover trial in patients with PXE. Patients were allocated 30 mg/day of lansoprazole or a placebo in two sequences of 8 weeks. The primary outcome was the differences in plasma PPi levels between the placebo and lansoprazole phases. 29 patients were included in the study. There were eight drop-outs due to the pandemic lockdown after the first visit and one due to gastric intolerance, so twenty patients completed the trial. A generalized linear mixed model was used to evaluate the effect of lansoprazole. Overall, lansoprazole increased plasma PPi levels from 0.34 ± 0.10 µM to 0.41 ± 0.16 µM (p = 0.0302), with no statistically significant changes in TNAP activity. There were no important adverse events. 30 mg/day of lansoprazole was able to significantly increase plasma PPi in patients with PXE; despite this, the study should be replicated with a large number of participants in a multicenter trial, with a clinical end point as the primary outcome." @default.
• W4323046256 created "2023-03-04" @default.
• W4323046256 creator A5010916174 @default.
• W4323046256 creator A5046690818 @default.
• W4323046256 creator A5051701344 @default.
• W4323046256 creator A5052591042 @default.
• W4323046256 creator A5056260879 @default.
• W4323046256 creator A5061978772 @default.
• W4323046256 creator A5071267680 @default.
• W4323046256 creator A5072815031 @default.
• W4323046256 creator A5078144116 @default.
• W4323046256 creator A5080609002 @default.
• W4323046256 creator A5085076303 @default.
• W4323046256 date "2023-03-03" @default.
• W4323046256 modified "2023-10-18" @default.
• W4323046256 title "Lansoprazole Increases Inorganic Pyrophosphate in Patients with Pseudoxanthoma Elasticum: A Double-Blind, Randomized, Placebo-Controlled Crossover Trial" @default.
• W4323046256 cites W1563718788 @default.
• W4323046256 cites W1605020879 @default.
• W4323046256 cites W2029211558 @default.
• W4323046256 cites W2034934192 @default.
• W4323046256 cites W2044067984 @default.
• W4323046256 cites W2116191608 @default.
• W4323046256 cites W2121202172 @default.
• W4323046256 cites W2123591590 @default.
• W4323046256 cites W2131795083 @default.
• W4323046256 cites W2146914443 @default.
• W4323046256 cites W2283362891 @default.
• W4323046256 cites W2288132066 @default.
• W4323046256 cites W2735738388 @default.
• W4323046256 cites W2788948195 @default.
• W4323046256 cites W2790597051 @default.
• W4323046256 cites W2810056747 @default.
• W4323046256 cites W2885313290 @default.
• W4323046256 cites W2918505439 @default.
• W4323046256 cites W2944434778 @default.
• W4323046256 cites W2944637852 @default.
• W4323046256 cites W2955930369 @default.
• W4323046256 cites W2979720017 @default.
• W4323046256 cites W2995148693 @default.
• W4323046256 cites W2996716482 @default.
• W4323046256 cites W3020836979 @default.
• W4323046256 cites W3172895000 @default.
• W4323046256 cites W3174699165 @default.
• W4323046256 cites W3213743700 @default.
• W4323046256 cites W4212939246 @default.
• W4323046256 cites W4229054505 @default.
• W4323046256 cites W4229068618 @default.
• W4323046256 cites W4281710582 @default.
• W4323046256 cites W4312115361 @default.
• W4323046256 doi "https://doi.org/10.3390/ijms24054899" @default.
• W4323046256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36902331" @default.
• W4323046256 hasPublicationYear "2023" @default.
• W4323046256 type Work @default.
• W4323046256 citedByCount "0" @default.
• W4323046256 crossrefType "journal-article" @default.
• W4323046256 hasAuthorship W4323046256A5010916174 @default.
• W4323046256 hasAuthorship W4323046256A5046690818 @default.
• W4323046256 hasAuthorship W4323046256A5051701344 @default.
• W4323046256 hasAuthorship W4323046256A5052591042 @default.
• W4323046256 hasAuthorship W4323046256A5056260879 @default.
• W4323046256 hasAuthorship W4323046256A5061978772 @default.
• W4323046256 hasAuthorship W4323046256A5071267680 @default.
• W4323046256 hasAuthorship W4323046256A5072815031 @default.
• W4323046256 hasAuthorship W4323046256A5078144116 @default.
• W4323046256 hasAuthorship W4323046256A5080609002 @default.
• W4323046256 hasAuthorship W4323046256A5085076303 @default.
• W4323046256 hasBestOaLocation W43230462561 @default.
• W4323046256 hasConcept C126322002 @default.
• W4323046256 hasConcept C142724271 @default.
• W4323046256 hasConcept C168563851 @default.
• W4323046256 hasConcept C185592680 @default.
• W4323046256 hasConcept C204787440 @default.
• W4323046256 hasConcept C27081682 @default.
• W4323046256 hasConcept C2777498785 @default.
• W4323046256 hasConcept C2778028898 @default.
• W4323046256 hasConcept C2778715759 @default.
• W4323046256 hasConcept C71924100 @default.
• W4323046256 hasConcept C87813604 @default.
• W4323046256 hasConcept C90924648 @default.
• W4323046256 hasConceptScore W4323046256C126322002 @default.
• W4323046256 hasConceptScore W4323046256C142724271 @default.
• W4323046256 hasConceptScore W4323046256C168563851 @default.
• W4323046256 hasConceptScore W4323046256C185592680 @default.
• W4323046256 hasConceptScore W4323046256C204787440 @default.
• W4323046256 hasConceptScore W4323046256C27081682 @default.
• W4323046256 hasConceptScore W4323046256C2777498785 @default.
• W4323046256 hasConceptScore W4323046256C2778028898 @default.
• W4323046256 hasConceptScore W4323046256C2778715759 @default.
• W4323046256 hasConceptScore W4323046256C71924100 @default.
• W4323046256 hasConceptScore W4323046256C87813604 @default.
• W4323046256 hasConceptScore W4323046256C90924648 @default.
• W4323046256 hasIssue "5" @default.
• W4323046256 hasLocation W43230462561 @default.
• W4323046256 hasLocation W43230462562 @default.
• W4323046256 hasLocation W43230462563 @default.
• W4323046256 hasLocation W43230462564 @default.
• W4323046256 hasOpenAccess W4323046256 @default.
• W4323046256 hasPrimaryLocation W43230462561 @default.

• next