Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323048249> ?p ?o ?g. }
- W4323048249 abstract "Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular processes including axon pathfinding, cell migration, adhesion, differentiation, and survival. Here, we present a molecular understanding of netrin-1 mediated interactions with glycosaminoglycan chains of diverse heparan sulfate proteoglycans (HSPGs) and short heparin oligosaccharides. Whereas interactions with HSPGs act as platform to co-localise netrin-1 close to the cell surface, heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1. Remarkably, the monomer-dimer equilibrium of netrin-1 in solution is abolished in the presence of heparin oligosaccharides and replaced with highly hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation. In our integrated approach we provide a molecular mechanism for the filament assembly which opens fresh paths towards a molecular understanding of netrin-1 functions." @default.
- W4323048249 created "2023-03-04" @default.
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- W4323048249 date "2023-03-03" @default.
- W4323048249 modified "2023-10-11" @default.
- W4323048249 title "The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation" @default.
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