FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323052179> ?p ?o ?g. }

• W4323052179 abstract "The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is linked to the presence of pancreatic cancer stem-like cells (CSCs) that respond poorly to current chemotherapy regimens. By small molecule compound screening targeting 142 epigenetic enzymes, we identified that bromodomain-containing protein BRD9, a component of the BAF histone remodelling complex, is a key chromatin regulator to orchestrate the stemness of pancreatic CSCs via cooperating with the TGFβ/Activin-SMAD2/3 signalling pathway. Inhibition and genetic ablation of BDR9 block the self-renewal, cell cycle entry into G0 phase and invasiveness of CSCs, and improve the sensitivity of CSCs to gemcitabine treatment. In addition, pharmacological inhibition of BRD9 significantly reduced the tumorigenesis in patient-derived xenografts mouse models and eliminated CSCs in tumours from pancreatic cancer patients. Mechanistically, inhibition of BRD9 disrupts enhancer-promoter looping and transcription of stemness genes in CSCs. Collectively, the data suggest BRD9 as a novel therapeutic target for PDAC treatment via modulation of CSC stemness." @default.
• W4323052179 created "2023-03-04" @default.
• W4323052179 creator A5000749022 @default.
• W4323052179 creator A5010735561 @default.
• W4323052179 creator A5011867023 @default.
• W4323052179 creator A5018147696 @default.
• W4323052179 creator A5030288845 @default.
• W4323052179 creator A5040058951 @default.
• W4323052179 creator A5041155406 @default.
• W4323052179 creator A5047079042 @default.
• W4323052179 creator A5047094607 @default.
• W4323052179 creator A5057514008 @default.
• W4323052179 creator A5060470951 @default.
• W4323052179 creator A5060685912 @default.
• W4323052179 creator A5061689835 @default.
• W4323052179 creator A5062054124 @default.
• W4323052179 creator A5066061339 @default.
• W4323052179 creator A5070129678 @default.
• W4323052179 creator A5070641211 @default.
• W4323052179 creator A5072926885 @default.
• W4323052179 creator A5077222290 @default.
• W4323052179 creator A5082308725 @default.
• W4323052179 creator A5085028455 @default.
• W4323052179 creator A5086014790 @default.
• W4323052179 creator A5087622795 @default.
• W4323052179 date "2023-03-02" @default.
• W4323052179 modified "2023-09-30" @default.
• W4323052179 title "BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma" @default.
• W4323052179 cites W1608762409 @default.
• W4323052179 cites W1675493788 @default.
• W4323052179 cites W1963985319 @default.
• W4323052179 cites W1968812902 @default.
• W4323052179 cites W1981030303 @default.
• W4323052179 cites W1988783376 @default.
• W4323052179 cites W1994070275 @default.
• W4323052179 cites W1996435746 @default.
• W4323052179 cites W1996588332 @default.
• W4323052179 cites W2003524961 @default.
• W4323052179 cites W2004302235 @default.
• W4323052179 cites W2011649365 @default.
• W4323052179 cites W2016849135 @default.
• W4323052179 cites W2019264784 @default.
• W4323052179 cites W2029443168 @default.
• W4323052179 cites W2069524976 @default.
• W4323052179 cites W2073377349 @default.
• W4323052179 cites W2090757807 @default.
• W4323052179 cites W2091015937 @default.
• W4323052179 cites W2103441770 @default.
• W4323052179 cites W2106578635 @default.
• W4323052179 cites W2107441200 @default.
• W4323052179 cites W2114104545 @default.
• W4323052179 cites W2122986552 @default.
• W4323052179 cites W2124649657 @default.
• W4323052179 cites W2131170195 @default.
• W4323052179 cites W2138155367 @default.
• W4323052179 cites W2146825820 @default.
• W4323052179 cites W2158789637 @default.
• W4323052179 cites W2159675211 @default.
• W4323052179 cites W2161817637 @default.
• W4323052179 cites W2165480504 @default.
• W4323052179 cites W2167312662 @default.
• W4323052179 cites W2171808845 @default.
• W4323052179 cites W2193079089 @default.
• W4323052179 cites W2273796682 @default.
• W4323052179 cites W2537413785 @default.
• W4323052179 cites W2593764076 @default.
• W4323052179 cites W2605411274 @default.
• W4323052179 cites W2746266812 @default.
• W4323052179 cites W2803724995 @default.
• W4323052179 cites W2885492789 @default.
• W4323052179 cites W2902716564 @default.
• W4323052179 cites W2911631359 @default.
• W4323052179 cites W2912550169 @default.
• W4323052179 cites W2941269293 @default.
• W4323052179 cites W2952947531 @default.
• W4323052179 cites W3007162511 @default.
• W4323052179 cites W3015208903 @default.
• W4323052179 cites W3042010229 @default.
• W4323052179 cites W3085439020 @default.
• W4323052179 cites W3089565134 @default.
• W4323052179 cites W3096839945 @default.
• W4323052179 cites W3118083551 @default.
• W4323052179 cites W3118990851 @default.
• W4323052179 cites W3159309654 @default.
• W4323052179 cites W3189965895 @default.
• W4323052179 cites W4211181525 @default.
• W4323052179 cites W4238403033 @default.
• W4323052179 cites W4307501600 @default.
• W4323052179 cites W4308253332 @default.
• W4323052179 cites W839105568 @default.
• W4323052179 doi "https://doi.org/10.1101/2023.03.02.530770" @default.
• W4323052179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36909530" @default.
• W4323052179 hasPublicationYear "2023" @default.
• W4323052179 type Work @default.
• W4323052179 citedByCount "0" @default.
• W4323052179 crossrefType "posted-content" @default.
• W4323052179 hasAuthorship W4323052179A5000749022 @default.
• W4323052179 hasAuthorship W4323052179A5010735561 @default.
• W4323052179 hasAuthorship W4323052179A5011867023 @default.
• W4323052179 hasAuthorship W4323052179A5018147696 @default.

• next