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• W4323054927 endingPage "503" @default.
• W4323054927 startingPage "491" @default.
• W4323054927 abstract "Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase involved in the metabolism of biologically active peptides. Its most important physiological function is the conversion of angiotensin II to angiotensin-(1–7), which initiates the protective arm of the renin–angiotensin system (RAS). To evaluate the physiological relevance of this revision of the RAS, numerous different animal models have been engineered with genetic alterations in ACE2 expression. The characterization of ACE-deficient mice led to the discovery of a second function of the protein being responsible for the trafficking of the neutral amino acid transporter B(0)AT1 to the plasma membrane of gut epithelial cells, thereby promoting the intestinal uptake of certain amino acids. These two different functions are mediated by two domains of ACE2 with homologies to ACE and to collectrin, respectively, which have been fused during evolution. Moreover, some coronaviruses, such as SARS-CoV and SARS-CoV-2, hijack ACE2 for their entry into host cells, and again genetically altered mouse models expressing human ACE2 became instrumental to study virus infection and to develop therapeutic strategies. This chapter will summarize the different transgenic and knockout mouse and rat models with altered expression of ACE2 and the insights they have provided for the functions of this versatile protein." @default.
• W4323054927 created "2023-03-05" @default.
• W4323054927 creator A5039371456 @default.
• W4323054927 creator A5059936166 @default.
• W4323054927 date "2023-01-01" @default.
• W4323054927 modified "2023-09-30" @default.
• W4323054927 title "Transgenic animal models for the functional analysis of ACE2" @default.
• W4323054927 cites W1516304808 @default.
• W4323054927 cites W1594727967 @default.
• W4323054927 cites W1791384833 @default.
• W4323054927 cites W1964982019 @default.
• W4323054927 cites W1966686940 @default.
• W4323054927 cites W1966865110 @default.
• W4323054927 cites W1980771632 @default.
• W4323054927 cites W1981694088 @default.
• W4323054927 cites W1990544851 @default.
• W4323054927 cites W1992425723 @default.
• W4323054927 cites W1998964868 @default.
• W4323054927 cites W2000040025 @default.
• W4323054927 cites W2002765492 @default.
• W4323054927 cites W2004840558 @default.
• W4323054927 cites W2007034829 @default.
• W4323054927 cites W2010503769 @default.
• W4323054927 cites W2011565627 @default.
• W4323054927 cites W2017614891 @default.
• W4323054927 cites W2023080320 @default.
• W4323054927 cites W2025672718 @default.
• W4323054927 cites W2025906550 @default.
• W4323054927 cites W2028507800 @default.
• W4323054927 cites W2029269323 @default.
• W4323054927 cites W2031777104 @default.
• W4323054927 cites W2032062610 @default.
• W4323054927 cites W2033190476 @default.
• W4323054927 cites W2042477769 @default.
• W4323054927 cites W2043343078 @default.
• W4323054927 cites W2043702192 @default.
• W4323054927 cites W2051738649 @default.
• W4323054927 cites W2052851394 @default.
• W4323054927 cites W2055646886 @default.
• W4323054927 cites W2056763550 @default.
• W4323054927 cites W2063069042 @default.
• W4323054927 cites W2073321185 @default.
• W4323054927 cites W2074438457 @default.
• W4323054927 cites W2083902337 @default.
• W4323054927 cites W2085943051 @default.
• W4323054927 cites W2086052108 @default.
• W4323054927 cites W2100104153 @default.
• W4323054927 cites W2100267160 @default.
• W4323054927 cites W2101176145 @default.
• W4323054927 cites W2109740270 @default.
• W4323054927 cites W2112011558 @default.
• W4323054927 cites W2112849422 @default.
• W4323054927 cites W2113332919 @default.
• W4323054927 cites W2117892119 @default.
• W4323054927 cites W2119768071 @default.
• W4323054927 cites W2126237345 @default.
• W4323054927 cites W2129541689 @default.
• W4323054927 cites W2129812418 @default.
• W4323054927 cites W2135832604 @default.
• W4323054927 cites W2138245658 @default.
• W4323054927 cites W2147515973 @default.
• W4323054927 cites W2148281534 @default.
• W4323054927 cites W2149146712 @default.
• W4323054927 cites W2153075644 @default.
• W4323054927 cites W2154841519 @default.
• W4323054927 cites W2157466080 @default.
• W4323054927 cites W2161399617 @default.
• W4323054927 cites W2161477365 @default.
• W4323054927 cites W2163610648 @default.
• W4323054927 cites W2164449616 @default.
• W4323054927 cites W2164963532 @default.
• W4323054927 cites W2171705481 @default.
• W4323054927 cites W2224884856 @default.
• W4323054927 cites W2255789882 @default.
• W4323054927 cites W2298153446 @default.
• W4323054927 cites W2298465989 @default.
• W4323054927 cites W2328849045 @default.
• W4323054927 cites W2337247222 @default.
• W4323054927 cites W2561492009 @default.
• W4323054927 cites W2572076579 @default.
• W4323054927 cites W2747668193 @default.
• W4323054927 cites W2749925549 @default.
• W4323054927 cites W2774744396 @default.
• W4323054927 cites W2792389757 @default.
• W4323054927 cites W2792595120 @default.
• W4323054927 cites W2802435570 @default.
• W4323054927 cites W2891729799 @default.
• W4323054927 cites W2914853620 @default.
• W4323054927 cites W2971382717 @default.
• W4323054927 cites W2977713107 @default.
• W4323054927 cites W2981959799 @default.
• W4323054927 cites W3009912996 @default.
• W4323054927 cites W3010441732 @default.
• W4323054927 cites W3021880084 @default.
• W4323054927 cites W3031410383 @default.
• W4323054927 cites W3045720050 @default.
• W4323054927 cites W3048717165 @default.
• W4323054927 cites W3065141030 @default.

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