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• W4323067087 abstract "Abstract Background The sperm chromatin dispersion assay is commonly used to assess sperm DNA integrity. This approach is time‐consuming, demonstrates poor chromatin preservation, and provides an ambiguous and unstandardized evaluation of fragmented chromatin. Objectives We aimed to (i) develop an optimized sperm chromatin dispersion assay with reduced operation time, (ii) validate R10 test accuracy by comparing it to a conventional sperm chromatin dispersion assay, and (iii) standardize the sperm DNA fragmentation analysis procedure by integrating artificial intelligence optical microscopic technology. Materials and methods This cross‐section study included 620 semen samples. Aliquots were analyzed by a conventional Halosperm ® G2 assay (G2) and LensHooke ® R10 assay (R10). The DNA fragmentation index was scored manually, and R10 slides were automatically determined by a LensHooke ® X12 PRO semen analysis system (X12). Results We demonstrated significant improvements in total assay time (40 vs. 72 min, p < 0.001) and in the halo‐cytological resolution using R10 compared to G2. Comparing the G2 and R10, DNA fragmentation index results demonstrated good agreement between the two methods (Spearman's rank correlation, rho = 0.8517, p < 0.0001). We introduced the integration of an auto‐calculation system to diagnose sperm DNA fragmentation. X12 interpretation showed excellent agreement with manual interpretation (Spearman's rank correlation, rho = 0.9323, p < 0.0001), but had a low coefficient of variation compared to manual interpretation (4% for R10 by X12 vs. 19% for R10 by manual scoring vs. 25% for G2 by manual scoring). DNA fragmentation index was more correlated with total motility (coefficients = −0.3607, p < 0.0001) than sperm morphology and was positively associated with asthenozoospermic semen samples ( p = 0.0001). Conclusion The R10 sperm chromatin dispersion assay combined with the X12 semen analysis system is faster, more objective, and provides standardization for sperm DNA fragmentation." @default.
• W4323067087 created "2023-03-05" @default.
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• W4323067087 date "2023-03-15" @default.
• W4323067087 modified "2023-10-17" @default.
• W4323067087 title "Development and integration of LensHooke^® R10 for automatic and standardized diagnosis for sperm DNA fragmentation" @default.
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• W4323067087 doi "https://doi.org/10.1111/andr.13419" @default.
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