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- W4323075188 abstract "Abstract YES proto‐oncogene 1 (YES1) is an SRC family kinase (SFK) that plays a key role in cancer cell proliferation, adhesion, invasion, survival, and angiogenesis during tumorigenesis and tumor development. Reports suggest that YES1 amplification is associated with resistance to chemotherapeutic drugs and tyrosine kinase inhibitors (TKIs) in human malignancies. However, the mechanisms of drug resistance have not been fully elucidated. In this article, we review the literature on YES1 and discuss the implications of YES1 signaling for targeted therapy and chemotherapy resistance in malignancies. Moreover, recent advances in targeted therapy for YES1 ‐amplified malignancies are summarized. Finally, we conclude that targeting YES1 may reverse drug resistance and serve as a valuable tumor treatment strategy." @default.
- W4323075188 created "2023-03-05" @default.
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- W4323075188 date "2023-03-03" @default.
- W4323075188 modified "2023-10-12" @default.
- W4323075188 title "Role of YES1 signaling in tumor therapy resistance" @default.
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- W4323075188 doi "https://doi.org/10.1002/cai2.51" @default.
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