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• W4323075811 abstract "Abstract Fast synaptic inhibition determines neuronal response properties in the mammalian brain and is mediated by chloride-permeable ionotropic GABA-A receptors (GABA A Rs). Despite their fundamental role, it is still not known how GABA A Rs signal in the intact brain. Here we use in vivo gramicidin recordings to investigate synaptic GABA A R signaling in mouse cortical pyramidal neurons under conditions that preserve native transmembrane chloride gradients. In anaesthetized cortex, synaptic GABA A Rs exert classic hyperpolarizing effects. In contrast, GABA A R-mediated synaptic signaling in awake cortex is found to be predominantly shunting. This is due to more depolarized GABA A R equilibrium potentials (E GABAAR ), which are shown to result from the high levels of synaptic activity that characterize awake cortical networks. The E GABAAR observed in awake cortex can facilitate the decoupling of local networks, which improves the ability of the network to discriminate stimuli. Our findings therefore suggest that GABA A R signaling adapts to optimize cortical functions." @default.
• W4323075811 created "2023-03-05" @default.
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• W4323075811 date "2023-03-02" @default.
• W4323075811 modified "2023-10-10" @default.
• W4323075811 title "Active cortical networks promote shunting fast synaptic inhibition<i>in vivo</i>" @default.
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• W4323075811 doi "https://doi.org/10.1101/2023.03.01.530641" @default.
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