Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323262522> ?p ?o ?g. }
- W4323262522 endingPage "19" @default.
- W4323262522 startingPage "10" @default.
- W4323262522 abstract "Background and aimsA comparison of the amino acid (AA) plasma profile and markers of intestinal absorption-inflammation between healthy subjects aged 65–70 years and age-matched patients affected by stage 3b–4 chronic kidney disease (CKD3b-4) was performed.MethodsEleven healthy volunteers were compared with 12 CKD3b-4 patients at their first outpatient control (T0) and after 12-months (T12). Adherence to a low protein diet (LPD, 0.6 ± 0.1 g/kg/day) was assessed by Urea Nitrogen Appearance. The following parameters were assessed: renal function, nutritional parameters, bioelectrical impedance analysis, plasma levels of 20 total amino acids (TAAs), both essential (EAAs) including branched-chain amino acids (BCAAs) and non-essential (NEAAs). Zonulin and faecal Calprotectin markers were used to evaluate intestinal permeability/inflammation.ResultsFour patients dropped out of the study; in the remaining 8 residual kidney function (RKF) remained stable, their LPD adherence had risen to 0.89 g/kg/day, anaemia had worsened and extracellular body fluid had increased. In comparison to healthy subjects, TAA levels of histidine, arginine, asparagine, threonine, glycine, and glutamine had all increased. No variation in BCAAs was observed. A significant increase was detected in faecal calprotectin and zonulin levels in CKD patients as the disease progressed.ConclusionsThis study confirms the finding in aged patients of an alteration in plasmatic levels of several AAs secondary to uraemia. Intestinal markers provide confirmation of a relevant alteration to the intestinal function in CKD patients." @default.
- W4323262522 created "2023-03-06" @default.
- W4323262522 creator A5008906025 @default.
- W4323262522 creator A5015360713 @default.
- W4323262522 creator A5018640782 @default.
- W4323262522 creator A5021530952 @default.
- W4323262522 creator A5024414887 @default.
- W4323262522 creator A5039308028 @default.
- W4323262522 creator A5045181963 @default.
- W4323262522 creator A5046765942 @default.
- W4323262522 creator A5058940508 @default.
- W4323262522 creator A5063206718 @default.
- W4323262522 creator A5065296222 @default.
- W4323262522 creator A5071459011 @default.
- W4323262522 date "2023-06-01" @default.
- W4323262522 modified "2023-09-28" @default.
- W4323262522 title "Observational pilot study: A comparison of amino acids and derangement of intestinal function between healthy ageing subjects and patients affected by chronic kidney disease stage CKD3b-4 in conservative management" @default.
- W4323262522 cites W1203576684 @default.
- W4323262522 cites W1923056738 @default.
- W4323262522 cites W1968267475 @default.
- W4323262522 cites W1969156144 @default.
- W4323262522 cites W1987384005 @default.
- W4323262522 cites W1991638266 @default.
- W4323262522 cites W2011661361 @default.
- W4323262522 cites W2013557112 @default.
- W4323262522 cites W2019518173 @default.
- W4323262522 cites W2031017520 @default.
- W4323262522 cites W2049099916 @default.
- W4323262522 cites W2051156405 @default.
- W4323262522 cites W2077179028 @default.
- W4323262522 cites W2086124255 @default.
- W4323262522 cites W2093935755 @default.
- W4323262522 cites W2096114555 @default.
- W4323262522 cites W2101281764 @default.
- W4323262522 cites W2103145251 @default.
- W4323262522 cites W2111131756 @default.
- W4323262522 cites W2115001982 @default.
- W4323262522 cites W2131691531 @default.
- W4323262522 cites W2134389978 @default.
- W4323262522 cites W2145969129 @default.
- W4323262522 cites W2158881689 @default.
- W4323262522 cites W2190313991 @default.
- W4323262522 cites W2270441584 @default.
- W4323262522 cites W2290365562 @default.
- W4323262522 cites W2291733689 @default.
- W4323262522 cites W2410701927 @default.
- W4323262522 cites W2470431870 @default.
- W4323262522 cites W2580278050 @default.
- W4323262522 cites W2584412920 @default.
- W4323262522 cites W2584637411 @default.
- W4323262522 cites W2744470738 @default.
- W4323262522 cites W2766047719 @default.
- W4323262522 cites W2770074615 @default.
- W4323262522 cites W2790848722 @default.
- W4323262522 cites W2792317120 @default.
- W4323262522 cites W2809612313 @default.
- W4323262522 cites W2888425808 @default.
- W4323262522 cites W2900344589 @default.
- W4323262522 cites W2900698571 @default.
- W4323262522 cites W2909990926 @default.
- W4323262522 cites W2939135469 @default.
- W4323262522 cites W2945465871 @default.
- W4323262522 cites W2951646794 @default.
- W4323262522 cites W2969944752 @default.
- W4323262522 cites W2985692865 @default.
- W4323262522 cites W2995343586 @default.
- W4323262522 cites W3007511618 @default.
- W4323262522 cites W3015935721 @default.
- W4323262522 cites W3033680847 @default.
- W4323262522 cites W3034904480 @default.
- W4323262522 cites W3037569759 @default.
- W4323262522 cites W3085881798 @default.
- W4323262522 cites W3093887303 @default.
- W4323262522 cites W3096284313 @default.
- W4323262522 cites W3113331001 @default.
- W4323262522 cites W3126489239 @default.
- W4323262522 cites W3139366263 @default.
- W4323262522 cites W3157547099 @default.
- W4323262522 cites W3158916031 @default.
- W4323262522 cites W3162575323 @default.
- W4323262522 cites W3173062350 @default.
- W4323262522 cites W3187545458 @default.
- W4323262522 cites W3193285699 @default.
- W4323262522 cites W3193434066 @default.
- W4323262522 cites W3211414366 @default.
- W4323262522 cites W4200547561 @default.
- W4323262522 cites W4211178974 @default.
- W4323262522 cites W4245090897 @default.
- W4323262522 cites W4247934261 @default.
- W4323262522 cites W4360754414 @default.
- W4323262522 doi "https://doi.org/10.1016/j.clnesp.2023.02.026" @default.
- W4323262522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37202032" @default.
- W4323262522 hasPublicationYear "2023" @default.
- W4323262522 type Work @default.
- W4323262522 citedByCount "0" @default.
- W4323262522 crossrefType "journal-article" @default.
- W4323262522 hasAuthorship W4323262522A5008906025 @default.
- W4323262522 hasAuthorship W4323262522A5015360713 @default.