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- W4323275419 abstract "Inflammatory factors have emerged as key pathophysiological molecules involved in the progression of acute and chronic kidney disease. However, the anti-inflammatory effect of interleukin-10 (IL-10) is largely attenuated because of its insufficient concentration in an injured kidney. To overcome this challenge, we demonstrate in this study that platelet (PLT) camouflaged IL-10 ([email protected]) can selectively accumulate in injured kidneys for treating kidney inflammation and resulting complications. In this system, the PLT drug carrier maintained its original attributes over the study duration, with a good inflammation target effect, confirmed by in vivo imaging. [email protected] could be activated and aggregated, and also released IL-10 at the injury site in the kidney because of high levels of Tumor Necrosis Factor-α (TNF-α). Compared with free IL-10, [email protected] displayed a higher anti-inflammatory effect with fewer mitochondrial disorders (P < 0.01) and lower expression of NOD-like receptor (NLR)-P3 (NLRP3) (P < 0.05), resulting in reduced inflammation and pyroptosis in ischemia/reperfusion injury (I/R) mice. Treatment with [email protected] also exhibited significantly reduced nuclear factor kappa-B (NF-kB) expression, reduced inflammatory response, as well as improved renal fibrosis (P < 0.05) in the recovery phase in unilateral ureteral obstruction (UUO) mice. At the same time, [email protected] therapy continued to exhibit a favorable safety profile. This study established a promising approach for I/R- and UUO-induced kidney injury and fibrosis by taking advantage of the high accumulation and strong anti-inflammatory of [email protected]. Our study also reveals the importance PLT as an effective drug carrier for targeted therapies." @default.
- W4323275419 created "2023-03-06" @default.
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- W4323275419 date "2023-04-01" @default.
- W4323275419 modified "2023-10-17" @default.
- W4323275419 title "Platelet shipped IL-10 enhances drug delivery for attenuating I/R- or UUO-induced renal injury" @default.
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- W4323275419 doi "https://doi.org/10.1016/j.cej.2023.142258" @default.
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