FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323294899> ?p ?o ?g. }

• W4323294899 abstract "Neisseria gonorrhoeae (GC) is a obligate human pathogen responsible for gonorrhea, one of the most common sexually transmitted infections. The yearly increased multidrug resistance in GC has led to treatment failure clinically, suggesting an urgent need for novel therapy to combat this global health issue. AS101 [ammonium trichloro(dioxoethylene-O,O'-)tellurate], a tellurium-based compound previously used as an immunomodulatory agent, was found to have antimicrobial effects against Klebsiella pneumoniae via a high-throughput drug screening and showed antibacterial activity against Acinetobacter spp. This study aimed to evaluate the in vitro anti-gonococcal activity of AS101, including its antimicrobial activity, biofilm and infectivity inhibition, and potential underlying mechanisms. The agar-dilution-based MIC was used. The inhibition of GC microcolony formation and continual growth by AS101 was assessed by microscopy. The effect of AS101 on GC infectivity was evaluated by infecting endocervical ME180 and colorectal T84 epithelial cell lines. The mode of action was evaluated by a time-killing curve, transmission electron microscopy (TEM), and the level of reactive oxygen species (ROS). The MICs of MS11 and WHO GC isolates were both found to be 0.05 μg/mL. The biofilm formation, continual growth, and infectivity of two epithelial cell lines were significantly decreased with AS101 treatment. The time-kill curve, similar to that of azithromycin, suggested that AS101 is a bacteriostatic antimicrobial. However, TEM and ROS levels implied a mode of action different from that of azithromycin. Our findings highlighted the robust anti-gonococcal activities of AS101, which potentiates its use as a future antimicrobial for GC. IMPORTANCE Neisseria gonorrhoeae is an obligate human pathogen responsible for gonorrhea, one of the most common sexually transmitted infections. The yearly increased multidrug resistance in GC has led to treatment failure clinically, suggesting an urgent need for novel therapy to combat the global health issue. This study aimed to evaluate the in vitro anti-gonococcal activity of a previous immunomodulatory agent, AS101, and its underlying mechanisms. Here, we report that AS101 possesses remarkable anti-gonococcal activity. These findings supported further studies on in vivo experiments and formulations for the clinical application of AS101 as an anti-gonococcal agent." @default.
• W4323294899 created "2023-03-07" @default.
• W4323294899 creator A5004553318 @default.
• W4323294899 creator A5028971629 @default.
• W4323294899 creator A5038010570 @default.
• W4323294899 creator A5039349420 @default.
• W4323294899 creator A5055424928 @default.
• W4323294899 creator A5067716788 @default.
• W4323294899 creator A5079365625 @default.
• W4323294899 creator A5084302435 @default.
• W4323294899 date "2023-04-13" @default.
• W4323294899 modified "2023-09-30" @default.
• W4323294899 title "<i>In Vitro</i> Evaluation of Tellurium-Based AS101 Compound against Neisseria gonorrhoeae Infectivity" @default.
• W4323294899 cites W1109749069 @default.
• W4323294899 cites W1536376967 @default.
• W4323294899 cites W1599263328 @default.
• W4323294899 cites W1964231265 @default.
• W4323294899 cites W1964961805 @default.
• W4323294899 cites W2015775910 @default.
• W4323294899 cites W2092028271 @default.
• W4323294899 cites W2116277671 @default.
• W4323294899 cites W2117543713 @default.
• W4323294899 cites W2118758170 @default.
• W4323294899 cites W2122744382 @default.
• W4323294899 cites W2139391701 @default.
• W4323294899 cites W2143401494 @default.
• W4323294899 cites W2158080844 @default.
• W4323294899 cites W2175741618 @default.
• W4323294899 cites W2292091275 @default.
• W4323294899 cites W2460894723 @default.
• W4323294899 cites W2462093517 @default.
• W4323294899 cites W2519761790 @default.
• W4323294899 cites W2520168328 @default.
• W4323294899 cites W2578495584 @default.
• W4323294899 cites W2613021898 @default.
• W4323294899 cites W2789808681 @default.
• W4323294899 cites W2803660889 @default.
• W4323294899 cites W2808490053 @default.
• W4323294899 cites W2889693598 @default.
• W4323294899 cites W2978418147 @default.
• W4323294899 cites W2998465737 @default.
• W4323294899 cites W3023266079 @default.
• W4323294899 cites W3088775449 @default.
• W4323294899 cites W3111151712 @default.
• W4323294899 cites W3192914422 @default.
• W4323294899 cites W3193426294 @default.
• W4323294899 cites W4200156776 @default.
• W4323294899 cites W4210955077 @default.
• W4323294899 cites W4213322270 @default.
• W4323294899 doi "https://doi.org/10.1128/spectrum.01496-22" @default.
• W4323294899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36877078" @default.
• W4323294899 hasPublicationYear "2023" @default.
• W4323294899 type Work @default.
• W4323294899 citedByCount "0" @default.
• W4323294899 crossrefType "journal-article" @default.
• W4323294899 hasAuthorship W4323294899A5004553318 @default.
• W4323294899 hasAuthorship W4323294899A5028971629 @default.
• W4323294899 hasAuthorship W4323294899A5038010570 @default.
• W4323294899 hasAuthorship W4323294899A5039349420 @default.
• W4323294899 hasAuthorship W4323294899A5055424928 @default.
• W4323294899 hasAuthorship W4323294899A5067716788 @default.
• W4323294899 hasAuthorship W4323294899A5079365625 @default.
• W4323294899 hasAuthorship W4323294899A5084302435 @default.
• W4323294899 hasBestOaLocation W43232948991 @default.
• W4323294899 hasConcept C106358424 @default.
• W4323294899 hasConcept C121587506 @default.
• W4323294899 hasConcept C159047783 @default.
• W4323294899 hasConcept C2522874641 @default.
• W4323294899 hasConcept C2778907293 @default.
• W4323294899 hasConcept C2779166590 @default.
• W4323294899 hasConcept C33070731 @default.
• W4323294899 hasConcept C4937899 @default.
• W4323294899 hasConcept C501593827 @default.
• W4323294899 hasConcept C86803240 @default.
• W4323294899 hasConcept C89423630 @default.
• W4323294899 hasConceptScore W4323294899C106358424 @default.
• W4323294899 hasConceptScore W4323294899C121587506 @default.
• W4323294899 hasConceptScore W4323294899C159047783 @default.
• W4323294899 hasConceptScore W4323294899C2522874641 @default.
• W4323294899 hasConceptScore W4323294899C2778907293 @default.
• W4323294899 hasConceptScore W4323294899C2779166590 @default.
• W4323294899 hasConceptScore W4323294899C33070731 @default.
• W4323294899 hasConceptScore W4323294899C4937899 @default.
• W4323294899 hasConceptScore W4323294899C501593827 @default.
• W4323294899 hasConceptScore W4323294899C86803240 @default.
• W4323294899 hasConceptScore W4323294899C89423630 @default.
• W4323294899 hasIssue "2" @default.
• W4323294899 hasLocation W43232948991 @default.
• W4323294899 hasLocation W43232948992 @default.
• W4323294899 hasLocation W43232948993 @default.
• W4323294899 hasOpenAccess W4323294899 @default.
• W4323294899 hasPrimaryLocation W43232948991 @default.
• W4323294899 hasRelatedWork W1968322066 @default.
• W4323294899 hasRelatedWork W2027932282 @default.
• W4323294899 hasRelatedWork W2073004064 @default.
• W4323294899 hasRelatedWork W2152718845 @default.
• W4323294899 hasRelatedWork W2742443309 @default.
• W4323294899 hasRelatedWork W2891613987 @default.
• W4323294899 hasRelatedWork W3048784711 @default.
• W4323294899 hasRelatedWork W3191141701 @default.

• next