FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323304858> ?p ?o ?g. }

• W4323304858 endingPage "133623" @default.
• W4323304858 startingPage "133623" @default.
• W4323304858 abstract "Circulating tumor DNA (ctDNA) is an important biomarker for liquid biopsy. Unfortunately, the detection of ctDNA is still challenging unless these obstacles, such as unsatisfactory sensitivity, time-consuming processes, and high costs, are solved. Herein, the first paradigm of nanomaterial’s application in CRISPR/Cas12a system with enhanced fluorescence readout was reported in this work. We designed and prepared a class of metal-organic framework (MOF) based fluorescent labels with stimulus response to control the release of fluorescent molecules. Notably, the MOF-based fluorescent labels was able to optimize traditional CRISPR/Cas12a detection system with fluorescence readout, which improved the detection sensitivity over four orders of magnitude to meet the requirements of trace ctDNA detection. We integrated the MOF-based fluorescent labels and CRISPR/Cas12a system to achieve ultrasensitive and convenient detection of target ctDNA. Aiming at Kirsten rat sarcoma-2 virus point mutations, the proposed strategy exhibited ultrahigh sensitivity for detecting target ctDNA as low as 5.6 fM, which had been successfully employed to quantify target ctDNA in clinical serum samples. The quantitative results could distinguish lung cancer patients from healthy person with high specificity and sensitivity, which had a broad application prospect in clinical diagnosis." @default.
• W4323304858 created "2023-03-07" @default.
• W4323304858 creator A5008256879 @default.
• W4323304858 creator A5042428882 @default.
• W4323304858 creator A5049761738 @default.
• W4323304858 creator A5052709439 @default.
• W4323304858 creator A5064189236 @default.
• W4323304858 creator A5075000300 @default.
• W4323304858 date "2023-05-01" @default.
• W4323304858 modified "2023-10-16" @default.
• W4323304858 title "CRISPR/Cas12a bio-assay integrated with metal-organic framework based enhanced fluorescent labels for ultrasensitive detection of circulating tumor DNA" @default.
• W4323304858 cites W1892598562 @default.
• W4323304858 cites W1963853602 @default.
• W4323304858 cites W1991581123 @default.
• W4323304858 cites W2051340943 @default.
• W4323304858 cites W2503953373 @default.
• W4323304858 cites W2516846277 @default.
• W4323304858 cites W2558046062 @default.
• W4323304858 cites W2559793130 @default.
• W4323304858 cites W2586862787 @default.
• W4323304858 cites W2590954301 @default.
• W4323304858 cites W2787024379 @default.
• W4323304858 cites W2793969139 @default.
• W4323304858 cites W2808752358 @default.
• W4323304858 cites W2900771557 @default.
• W4323304858 cites W2999723416 @default.
• W4323304858 cites W3004744434 @default.
• W4323304858 cites W3010810358 @default.
• W4323304858 cites W3014526042 @default.
• W4323304858 cites W3017334101 @default.
• W4323304858 cites W3034309411 @default.
• W4323304858 cites W3103967548 @default.
• W4323304858 cites W3109667847 @default.
• W4323304858 cites W3111894463 @default.
• W4323304858 cites W3142733986 @default.
• W4323304858 cites W3162645281 @default.
• W4323304858 cites W3203041419 @default.
• W4323304858 cites W3205842424 @default.
• W4323304858 cites W4206841660 @default.
• W4323304858 cites W4210887972 @default.
• W4323304858 cites W4229916464 @default.
• W4323304858 cites W4283367411 @default.
• W4323304858 cites W4285387277 @default.
• W4323304858 cites W4304014879 @default.
• W4323304858 doi "https://doi.org/10.1016/j.snb.2023.133623" @default.
• W4323304858 hasPublicationYear "2023" @default.
• W4323304858 type Work @default.
• W4323304858 citedByCount "0" @default.
• W4323304858 crossrefType "journal-article" @default.
• W4323304858 hasAuthorship W4323304858A5008256879 @default.
• W4323304858 hasAuthorship W4323304858A5042428882 @default.
• W4323304858 hasAuthorship W4323304858A5049761738 @default.
• W4323304858 hasAuthorship W4323304858A5052709439 @default.
• W4323304858 hasAuthorship W4323304858A5064189236 @default.
• W4323304858 hasAuthorship W4323304858A5075000300 @default.
• W4323304858 hasConcept C104317684 @default.
• W4323304858 hasConcept C121332964 @default.
• W4323304858 hasConcept C121608353 @default.
• W4323304858 hasConcept C128972844 @default.
• W4323304858 hasConcept C153911025 @default.
• W4323304858 hasConcept C171250308 @default.
• W4323304858 hasConcept C185592680 @default.
• W4323304858 hasConcept C192562407 @default.
• W4323304858 hasConcept C2779529041 @default.
• W4323304858 hasConcept C2781335228 @default.
• W4323304858 hasConcept C54355233 @default.
• W4323304858 hasConcept C552990157 @default.
• W4323304858 hasConcept C55493867 @default.
• W4323304858 hasConcept C62520636 @default.
• W4323304858 hasConcept C70721500 @default.
• W4323304858 hasConcept C86803240 @default.
• W4323304858 hasConcept C91881484 @default.
• W4323304858 hasConcept C98108389 @default.
• W4323304858 hasConceptScore W4323304858C104317684 @default.
• W4323304858 hasConceptScore W4323304858C121332964 @default.
• W4323304858 hasConceptScore W4323304858C121608353 @default.
• W4323304858 hasConceptScore W4323304858C128972844 @default.
• W4323304858 hasConceptScore W4323304858C153911025 @default.
• W4323304858 hasConceptScore W4323304858C171250308 @default.
• W4323304858 hasConceptScore W4323304858C185592680 @default.
• W4323304858 hasConceptScore W4323304858C192562407 @default.
• W4323304858 hasConceptScore W4323304858C2779529041 @default.
• W4323304858 hasConceptScore W4323304858C2781335228 @default.
• W4323304858 hasConceptScore W4323304858C54355233 @default.
• W4323304858 hasConceptScore W4323304858C552990157 @default.
• W4323304858 hasConceptScore W4323304858C55493867 @default.
• W4323304858 hasConceptScore W4323304858C62520636 @default.
• W4323304858 hasConceptScore W4323304858C70721500 @default.
• W4323304858 hasConceptScore W4323304858C86803240 @default.
• W4323304858 hasConceptScore W4323304858C91881484 @default.
• W4323304858 hasConceptScore W4323304858C98108389 @default.
• W4323304858 hasLocation W43233048581 @default.
• W4323304858 hasOpenAccess W4323304858 @default.
• W4323304858 hasPrimaryLocation W43233048581 @default.
• W4323304858 hasRelatedWork W2331287810 @default.
• W4323304858 hasRelatedWork W2989125290 @default.
• W4323304858 hasRelatedWork W3006367027 @default.
• W4323304858 hasRelatedWork W3165157391 @default.

• next