FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323304879> ?p ?o ?g. }

• W4323304879 endingPage "147338" @default.
• W4323304879 startingPage "147338" @default.
• W4323304879 abstract "Rheumatoid arthritis (RA) is an inflammatory condition that primarily affects the joints and progress to affect other vital organs. Variety of drugs are being recommended to control the disease progression that benefits patients to perform day-to-day activities. Few of these RA drugs have noticeable side effects; therefore, it's crucial to choose the appropriate drug for treating RA with an understanding of the disease's pathophysiology. Herein, we investigated the RA genes from GWAS data to construct protein–protein interaction (PPI) network and to define appropriate drug targets for RA. The predicted drug targets were screened with the known RA drugs based on molecular docking. Further, the molecular dynamics simulations were performed to comprehend the conformational changes and stability of the targets upon binding of the selected top ranked RA drug. As a result, our constructed protein network from GWAS data revealed, STAT3 and IL2 could be potential pharmacogenetics targets that interlink most of the RA genes encoding proteins. These interlinked proteins of both the targets showed involvement in cell signaling, immune response, and TNF signaling pathway. Among the 192 RA drugs investigated, zoledronic acid had the lowest binding energy that inhibit both STAT3 (-6.307 kcal/mol) and IL2 (-6.231 kcal/mol). Additionally, STAT3 and IL2 trajectories on zoledronic acid binding exhibit notable differences in MD simulations as compared to a drug-free environment. Also, the in vitro assessment with the zoledronic acid confirms the outcome of our computational study. Overall, our study identify zoledronic acid could be potential inhibitor against these targets, that will benefits patients with RA. Comparative efficiency assessments between the RA drugs through clinical trials are needed to validate our findings in the treatment of RA." @default.
• W4323304879 created "2023-03-07" @default.
• W4323304879 creator A5002432049 @default.
• W4323304879 creator A5018141895 @default.
• W4323304879 creator A5022115569 @default.
• W4323304879 creator A5031380320 @default.
• W4323304879 creator A5039599940 @default.
• W4323304879 creator A5043326298 @default.
• W4323304879 creator A5084674191 @default.
• W4323304879 date "2023-05-01" @default.
• W4323304879 modified "2023-09-27" @default.
• W4323304879 title "Rheumatoid arthritis treatment with zoledronic acid, a potential inhibitor of GWAS-derived pharmacogenetics STAT3 and IL2 targets" @default.
• W4323304879 cites W1507322431 @default.
• W4323304879 cites W1885801568 @default.
• W4323304879 cites W1986137506 @default.
• W4323304879 cites W1988152696 @default.
• W4323304879 cites W1990273879 @default.
• W4323304879 cites W2038888556 @default.
• W4323304879 cites W2054134161 @default.
• W4323304879 cites W2054992861 @default.
• W4323304879 cites W2056841944 @default.
• W4323304879 cites W2069973593 @default.
• W4323304879 cites W2122066039 @default.
• W4323304879 cites W2124059797 @default.
• W4323304879 cites W2169773326 @default.
• W4323304879 cites W2586251728 @default.
• W4323304879 cites W2604334766 @default.
• W4323304879 cites W2766854006 @default.
• W4323304879 cites W2769997895 @default.
• W4323304879 cites W2802240459 @default.
• W4323304879 cites W2803973097 @default.
• W4323304879 cites W2905330547 @default.
• W4323304879 cites W2923746368 @default.
• W4323304879 cites W2981295652 @default.
• W4323304879 cites W3023544438 @default.
• W4323304879 cites W3044906678 @default.
• W4323304879 cites W3131778757 @default.
• W4323304879 cites W3173786447 @default.
• W4323304879 cites W3199841527 @default.
• W4323304879 cites W4226031774 @default.
• W4323304879 cites W4303961862 @default.
• W4323304879 doi "https://doi.org/10.1016/j.gene.2023.147338" @default.
• W4323304879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36889532" @default.
• W4323304879 hasPublicationYear "2023" @default.
• W4323304879 type Work @default.
• W4323304879 citedByCount "0" @default.
• W4323304879 crossrefType "journal-article" @default.
• W4323304879 hasAuthorship W4323304879A5002432049 @default.
• W4323304879 hasAuthorship W4323304879A5018141895 @default.
• W4323304879 hasAuthorship W4323304879A5022115569 @default.
• W4323304879 hasAuthorship W4323304879A5031380320 @default.
• W4323304879 hasAuthorship W4323304879A5039599940 @default.
• W4323304879 hasAuthorship W4323304879A5043326298 @default.
• W4323304879 hasAuthorship W4323304879A5084674191 @default.
• W4323304879 hasConcept C104317684 @default.
• W4323304879 hasConcept C106208931 @default.
• W4323304879 hasConcept C126322002 @default.
• W4323304879 hasConcept C135763542 @default.
• W4323304879 hasConcept C153209595 @default.
• W4323304879 hasConcept C159110408 @default.
• W4323304879 hasConcept C203014093 @default.
• W4323304879 hasConcept C2776326535 @default.
• W4323304879 hasConcept C2777575956 @default.
• W4323304879 hasConcept C2780035454 @default.
• W4323304879 hasConcept C41685203 @default.
• W4323304879 hasConcept C54355233 @default.
• W4323304879 hasConcept C70721500 @default.
• W4323304879 hasConcept C71924100 @default.
• W4323304879 hasConcept C86803240 @default.
• W4323304879 hasConcept C98274493 @default.
• W4323304879 hasConceptScore W4323304879C104317684 @default.
• W4323304879 hasConceptScore W4323304879C106208931 @default.
• W4323304879 hasConceptScore W4323304879C126322002 @default.
• W4323304879 hasConceptScore W4323304879C135763542 @default.
• W4323304879 hasConceptScore W4323304879C153209595 @default.
• W4323304879 hasConceptScore W4323304879C159110408 @default.
• W4323304879 hasConceptScore W4323304879C203014093 @default.
• W4323304879 hasConceptScore W4323304879C2776326535 @default.
• W4323304879 hasConceptScore W4323304879C2777575956 @default.
• W4323304879 hasConceptScore W4323304879C2780035454 @default.
• W4323304879 hasConceptScore W4323304879C41685203 @default.
• W4323304879 hasConceptScore W4323304879C54355233 @default.
• W4323304879 hasConceptScore W4323304879C70721500 @default.
• W4323304879 hasConceptScore W4323304879C71924100 @default.
• W4323304879 hasConceptScore W4323304879C86803240 @default.
• W4323304879 hasConceptScore W4323304879C98274493 @default.
• W4323304879 hasLocation W43233048791 @default.
• W4323304879 hasLocation W43233048792 @default.
• W4323304879 hasOpenAccess W4323304879 @default.
• W4323304879 hasPrimaryLocation W43233048791 @default.
• W4323304879 hasRelatedWork W1983544050 @default.
• W4323304879 hasRelatedWork W2090576783 @default.
• W4323304879 hasRelatedWork W2124466768 @default.
• W4323304879 hasRelatedWork W2125138090 @default.
• W4323304879 hasRelatedWork W2136844671 @default.
• W4323304879 hasRelatedWork W2411378081 @default.
• W4323304879 hasRelatedWork W2564299030 @default.
• W4323304879 hasRelatedWork W2794783788 @default.

• next