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- W4323309618 abstract "Embryogenesis is one of the most important life stages because it determines an organism's healthy growth. However, embryos of externally fertilizing species, such as most fish, are directly exposed to the environment during development and may be threatened by DNA damaging factors (pollutants, UV, reactive oxygen species). To counteract the negative effects of DNA fragmentation, fish embryos evolved complex damage response pathways. DNA repair pathways have been extensively studied in some fish species, such as zebrafish (Danio rerio). Our literature review, on the other hand, revealed a paucity of knowledge about DNA damage response and repair in non-model aquaculture fish species. Further, several pieces of evidence underlie the additional role of DNA repair genes and proteins in organogenesis, spatiotemporal localization in different tissue, and its indispensability for normal embryo development. In this review, we will summarize features of different DNA repair pathways in course of fish embryo development. We describe how the expression of DNA repair genes and proteins is regulated during development, their organogenetic roles, and how the expression of DNA repair genes changes in response to genotoxic stress. This will aid in addressing the link between genotoxic stress and embryo phenotype. Furthermore, available data indicate that embryos can repair damaged DNA, but the effects of early-life stress may manifest later in life as behavioral changes, neoplasia, or neurodegeneration. Overall, we conclude that more research on DNA repair in fish embryos is needed." @default.
- W4323309618 created "2023-03-07" @default.
- W4323309618 creator A5005295328 @default.
- W4323309618 creator A5007683882 @default.
- W4323309618 creator A5017690299 @default.
- W4323309618 creator A5083425389 @default.
- W4323309618 date "2023-03-01" @default.
- W4323309618 modified "2023-09-30" @default.
- W4323309618 title "DNA repair genes play a variety of roles in the development of fish embryos" @default.
- W4323309618 cites W1022678588 @default.
- W4323309618 cites W1498045662 @default.
- W4323309618 cites W1520164532 @default.
- W4323309618 cites W1779185681 @default.
- W4323309618 cites W1900811710 @default.
- W4323309618 cites W1961074127 @default.
- W4323309618 cites W1967321299 @default.
- W4323309618 cites W1971559763 @default.
- W4323309618 cites W1981569224 @default.
- W4323309618 cites W1982018823 @default.
- W4323309618 cites W1983066436 @default.
- W4323309618 cites W1984377389 @default.
- W4323309618 cites W1987771199 @default.
- W4323309618 cites W1988967913 @default.
- W4323309618 cites W1989187489 @default.
- W4323309618 cites W1989358347 @default.
- W4323309618 cites W1990335933 @default.
- W4323309618 cites W1992177385 @default.
- W4323309618 cites W1995601165 @default.
- W4323309618 cites W1999314545 @default.
- W4323309618 cites W2007199577 @default.
- W4323309618 cites W2008485110 @default.
- W4323309618 cites W2013827564 @default.
- W4323309618 cites W2019312328 @default.
- W4323309618 cites W2019391041 @default.
- W4323309618 cites W2028630156 @default.
- W4323309618 cites W2028757631 @default.
- W4323309618 cites W2028973234 @default.
- W4323309618 cites W2038241119 @default.
- W4323309618 cites W2039860296 @default.
- W4323309618 cites W2046006793 @default.
- W4323309618 cites W2050192518 @default.
- W4323309618 cites W2051298041 @default.
- W4323309618 cites W2052492066 @default.
- W4323309618 cites W2058274661 @default.
- W4323309618 cites W2068026234 @default.
- W4323309618 cites W2069750713 @default.
- W4323309618 cites W2074416973 @default.
- W4323309618 cites W2075415219 @default.
- W4323309618 cites W2075870502 @default.
- W4323309618 cites W2075899471 @default.
- W4323309618 cites W2076029239 @default.
- W4323309618 cites W2077651032 @default.
- W4323309618 cites W2080553628 @default.
- W4323309618 cites W2081954164 @default.
- W4323309618 cites W2084147994 @default.
- W4323309618 cites W2096731080 @default.
- W4323309618 cites W2102552625 @default.
- W4323309618 cites W2105033032 @default.
- W4323309618 cites W2106647330 @default.
- W4323309618 cites W2110409902 @default.
- W4323309618 cites W2112428210 @default.
- W4323309618 cites W2115603195 @default.
- W4323309618 cites W2116760626 @default.
- W4323309618 cites W2117404792 @default.
- W4323309618 cites W2125349610 @default.
- W4323309618 cites W2125745293 @default.
- W4323309618 cites W2134745259 @default.
- W4323309618 cites W2136704576 @default.
- W4323309618 cites W2137683543 @default.
- W4323309618 cites W2139229198 @default.
- W4323309618 cites W2163700254 @default.
- W4323309618 cites W2167069196 @default.
- W4323309618 cites W2170309011 @default.
- W4323309618 cites W2170481286 @default.
- W4323309618 cites W2185073681 @default.
- W4323309618 cites W2201691085 @default.
- W4323309618 cites W2316744180 @default.
- W4323309618 cites W2337611083 @default.
- W4323309618 cites W2528371319 @default.
- W4323309618 cites W2570584697 @default.
- W4323309618 cites W2572090623 @default.
- W4323309618 cites W2581663839 @default.
- W4323309618 cites W2612428976 @default.
- W4323309618 cites W2620613559 @default.
- W4323309618 cites W2626118374 @default.
- W4323309618 cites W269983673 @default.
- W4323309618 cites W2731803318 @default.
- W4323309618 cites W2756259848 @default.
- W4323309618 cites W2765420624 @default.
- W4323309618 cites W2768519858 @default.
- W4323309618 cites W2915881745 @default.
- W4323309618 cites W2941697941 @default.
- W4323309618 cites W2945474672 @default.
- W4323309618 cites W2980977558 @default.
- W4323309618 cites W2986367038 @default.
- W4323309618 cites W2991324771 @default.
- W4323309618 cites W3015960325 @default.
- W4323309618 cites W3037734947 @default.
- W4323309618 cites W3093954077 @default.
- W4323309618 cites W3101521458 @default.