Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323310071> ?p ?o ?g. }
- W4323310071 endingPage "10085" @default.
- W4323310071 startingPage "10077" @default.
- W4323310071 abstract "The alteration of ACE2 expression level, which has been studied in many diseases, makes the topic of ACE2 inducer potential crucial to be explored. The ACE2 inducer could further be designed to control the ACE2 expression level, which is appropriate to a specific case. An in vitro study of well-characterized carbon dots (CDs), made from citric acid and urea, was performed to determine their ability to modulate the ACE2 receptor. Gene expression of ACE2 was quantified using concentrations adjusted for IC50 results from CDs viability assays in HEK 293 and A549 cell lines. RT-qPCR was used to assess the expression of the ACE2 gene and its induction effect in normal cell lines (HEK-293A). According to the results of the tests, ACE2 is expressed in HEK-293A cell lines, and diminazene aceturate can increase ACE2 expression. The effect of CDs on ACE2 gene expression was further examined on the cell lines that had previously been induced with diminazene aceturate, which resulted in upregulation of the ACE2 expression level. An in silico study has been done by using a molecular docking approach. The molecular docking results show that CDs can make strong interactions with ACE2 amino acid residues through hydrophobic interaction, π–π interaction, π-cation interaction, and ionic interaction." @default.
- W4323310071 created "2023-03-07" @default.
- W4323310071 creator A5004410448 @default.
- W4323310071 creator A5014895373 @default.
- W4323310071 creator A5023321588 @default.
- W4323310071 creator A5058669609 @default.
- W4323310071 creator A5074152455 @default.
- W4323310071 creator A5075251280 @default.
- W4323310071 creator A5091702103 @default.
- W4323310071 date "2023-03-06" @default.
- W4323310071 modified "2023-10-17" @default.
- W4323310071 title "In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation" @default.
- W4323310071 cites W1963514652 @default.
- W4323310071 cites W1965390881 @default.
- W4323310071 cites W1972113011 @default.
- W4323310071 cites W1974901207 @default.
- W4323310071 cites W2028046413 @default.
- W4323310071 cites W2037985064 @default.
- W4323310071 cites W2054099227 @default.
- W4323310071 cites W2065715521 @default.
- W4323310071 cites W2091671824 @default.
- W4323310071 cites W2121530840 @default.
- W4323310071 cites W2134967712 @default.
- W4323310071 cites W2140325630 @default.
- W4323310071 cites W2154792548 @default.
- W4323310071 cites W2256593161 @default.
- W4323310071 cites W2301650719 @default.
- W4323310071 cites W2342868688 @default.
- W4323310071 cites W2404280981 @default.
- W4323310071 cites W2411823338 @default.
- W4323310071 cites W2411858661 @default.
- W4323310071 cites W2468168295 @default.
- W4323310071 cites W2624465932 @default.
- W4323310071 cites W2801417823 @default.
- W4323310071 cites W2904533952 @default.
- W4323310071 cites W2970999722 @default.
- W4323310071 cites W2981443459 @default.
- W4323310071 cites W3007757493 @default.
- W4323310071 cites W3014046418 @default.
- W4323310071 cites W3015134137 @default.
- W4323310071 cites W3033314946 @default.
- W4323310071 cites W3034310241 @default.
- W4323310071 cites W3036078153 @default.
- W4323310071 cites W3037545893 @default.
- W4323310071 cites W3037776677 @default.
- W4323310071 cites W3042832221 @default.
- W4323310071 cites W3100996285 @default.
- W4323310071 cites W3102414198 @default.
- W4323310071 cites W3120551159 @default.
- W4323310071 cites W3134047020 @default.
- W4323310071 cites W3139009944 @default.
- W4323310071 cites W3209167606 @default.
- W4323310071 cites W4200012711 @default.
- W4323310071 cites W4205773327 @default.
- W4323310071 cites W4206765133 @default.
- W4323310071 cites W4307971220 @default.
- W4323310071 cites W4313136221 @default.
- W4323310071 cites W4315648841 @default.
- W4323310071 doi "https://doi.org/10.1021/acsomega.2c07398" @default.
- W4323310071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36969408" @default.
- W4323310071 hasPublicationYear "2023" @default.
- W4323310071 type Work @default.
- W4323310071 citedByCount "0" @default.
- W4323310071 crossrefType "journal-article" @default.
- W4323310071 hasAuthorship W4323310071A5004410448 @default.
- W4323310071 hasAuthorship W4323310071A5014895373 @default.
- W4323310071 hasAuthorship W4323310071A5023321588 @default.
- W4323310071 hasAuthorship W4323310071A5058669609 @default.
- W4323310071 hasAuthorship W4323310071A5074152455 @default.
- W4323310071 hasAuthorship W4323310071A5075251280 @default.
- W4323310071 hasAuthorship W4323310071A5091702103 @default.
- W4323310071 hasBestOaLocation W43233100711 @default.
- W4323310071 hasConcept C104317684 @default.
- W4323310071 hasConcept C150194340 @default.
- W4323310071 hasConcept C159110408 @default.
- W4323310071 hasConcept C174510640 @default.
- W4323310071 hasConcept C185592680 @default.
- W4323310071 hasConcept C202751555 @default.
- W4323310071 hasConcept C2225953 @default.
- W4323310071 hasConcept C2775905019 @default.
- W4323310071 hasConcept C41685203 @default.
- W4323310071 hasConcept C54355233 @default.
- W4323310071 hasConcept C55493867 @default.
- W4323310071 hasConcept C71924100 @default.
- W4323310071 hasConcept C81885089 @default.
- W4323310071 hasConcept C86803240 @default.
- W4323310071 hasConcept C95444343 @default.
- W4323310071 hasConceptScore W4323310071C104317684 @default.
- W4323310071 hasConceptScore W4323310071C150194340 @default.
- W4323310071 hasConceptScore W4323310071C159110408 @default.
- W4323310071 hasConceptScore W4323310071C174510640 @default.
- W4323310071 hasConceptScore W4323310071C185592680 @default.
- W4323310071 hasConceptScore W4323310071C202751555 @default.
- W4323310071 hasConceptScore W4323310071C2225953 @default.
- W4323310071 hasConceptScore W4323310071C2775905019 @default.
- W4323310071 hasConceptScore W4323310071C41685203 @default.
- W4323310071 hasConceptScore W4323310071C54355233 @default.
- W4323310071 hasConceptScore W4323310071C55493867 @default.