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- W4323313749 endingPage "645" @default.
- W4323313749 startingPage "645" @default.
- W4323313749 abstract "G-quadruplexes (G4s) are short secondary DNA structures located throughout genomic DNA and transcribed RNA. Although G4 structures have been shown to form in vivo, no current search tools that examine these structures based on previously identified G-quadruplexes and filter them based on similar sequence, structure, and thermodynamic properties are known to exist. We present a framework for clustering G-quadruplex sequences into families using the CD-HIT, MeShClust, and DNACLUST methods along with a combination of Starcode and BLAST. Utilizing this framework to filter and annotate clusters, 95 families of G-quadruplex sequences were identified within the human genome. Profiles for each family were created using hidden Markov models to allow for the identification of additional family members and generate homology probability scores. The thermodynamic folding energy properties, functional annotation of genes associated with the sequences, scores from different prediction algorithms, and transcription factor binding motifs within a family were used to annotate and compare the diversity within and across clusters. The resulting set of G-quadruplex families can be used to further understand how different regions of the genome are regulated by factors targeting specific structures common to members of a specific cluster." @default.
- W4323313749 created "2023-03-07" @default.
- W4323313749 creator A5002804863 @default.
- W4323313749 creator A5017324963 @default.
- W4323313749 creator A5034707578 @default.
- W4323313749 date "2023-03-04" @default.
- W4323313749 modified "2023-10-01" @default.
- W4323313749 title "Structural and Functional Classification of G-Quadruplex Families within the Human Genome" @default.
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