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- W4323313869 endingPage "1617" @default.
- W4323313869 startingPage "1617" @default.
- W4323313869 abstract "Treatment for acute myeloid leukemia (AML) has evolved rapidly over the last decade as improved understanding of cytogenetic and molecular drivers of leukemogenesis refined survival prognostication and enabled development of targeted therapeutics. Molecularly targeted therapies are now approved for the treatment of FLT3 and IDH1/2-mutated AML and additional molecularly and cellularly targeted therapeutics are in development for defined patient subgroups. Alongside these welcome therapeutic advancements, increased understanding of leukemic biology and treatment resistance has resulted in clinical trials investigating combinations of cytotoxic, cellular, and molecularly targeted therapeutics resulting in improved response and survival outcomes in patients with AML. Herein, we comprehensively review the current landscape of IDH and FLT3 inhibitors in clinical practice for the treatment of AML, highlight known resistance mechanisms, and discuss new cellular or molecularly targeted therapies currently under investigation in ongoing early phase clinical trials." @default.
- W4323313869 created "2023-03-07" @default.
- W4323313869 creator A5056317446 @default.
- W4323313869 creator A5069176297 @default.
- W4323313869 creator A5088234044 @default.
- W4323313869 date "2023-03-06" @default.
- W4323313869 modified "2023-10-14" @default.
- W4323313869 title "Molecularly Targeted Therapy in Acute Myeloid Leukemia: Current Treatment Landscape and Mechanisms of Response and Resistance" @default.
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- W4323313869 doi "https://doi.org/10.3390/cancers15051617" @default.
- W4323313869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36900407" @default.
- W4323313869 hasPublicationYear "2023" @default.
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