FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323315259> ?p ?o ?g. }

• W4323315259 abstract "Abstract Aim Epidermal growth factor receptor (EGFR) is one of the most extensively studied molecular targets for newly developed antitumor drugs. Metformin, a widely used antidiabetic drug for type 2 diabetes, is expected to exhibit antitumor activity. Recently, it was reported that EGFR expression in tumor tissues from patients with type 2 diabetes was reduced in patients taking metformin compared with that in patients not taking metformin. Therefore, we investigated the effect of metformin on the expression of EGFR at the cellular level. Methods Cell lines derived from oral squamous cell carcinoma were used to investigate the effect of metformin on the cell proliferation and cellular content of EGFR. Cell proliferation was assessed by direct cell counting and water‐soluble tetrazolium (WST)‐based colorimetric assay. Expression level of EGFR messenger ribonucleic acid (mRNA) and protein were analyzed by real‐time polymerase chain reaction (PCR) and western blotting, respectively. Results The proliferation of all three cell lines used in this study (Ca9‐22, SAS, and HSC‐2) was suppressed by metformin. Metformin downregulated the cellular content of EGFR without affecting its mRNA expression. Ligand‐induced EGFR internalization was accelerated by metformin. Ligand‐induced EGFR degradation was inhibited by the lysosomal and proteasomal inhibitors bafilomycin A1 and MG132, respectively. Conclusion These results suggest that metformin reduces EGFR by modifying the intracellular trafficking of the receptor, for example, promoting ligand‐induced internalization and degradation of EGFR, rather than suppressing the synthesis of the receptor. The effect of metformin on EGFR may affect therapeutic outcomes when metformin is combined with existing cancer treatments." @default.
• W4323315259 created "2023-03-07" @default.
• W4323315259 creator A5018988574 @default.
• W4323315259 creator A5020773105 @default.
• W4323315259 creator A5039224202 @default.
• W4323315259 creator A5045348619 @default.
• W4323315259 creator A5059829379 @default.
• W4323315259 creator A5060319614 @default.
• W4323315259 creator A5064977104 @default.
• W4323315259 creator A5074919615 @default.
• W4323315259 date "2023-03-05" @default.
• W4323315259 modified "2023-10-17" @default.
• W4323315259 title "Enhanced degradation of epidermal growth factor receptor by metformin" @default.
• W4323315259 cites W1484764033 @default.
• W4323315259 cites W1748615418 @default.
• W4323315259 cites W1775421522 @default.
• W4323315259 cites W1974323653 @default.
• W4323315259 cites W1975425183 @default.
• W4323315259 cites W1979766088 @default.
• W4323315259 cites W1986343991 @default.
• W4323315259 cites W1998079639 @default.
• W4323315259 cites W2012125801 @default.
• W4323315259 cites W2014637718 @default.
• W4323315259 cites W2016752484 @default.
• W4323315259 cites W2022406746 @default.
• W4323315259 cites W2031136388 @default.
• W4323315259 cites W2050598007 @default.
• W4323315259 cites W2058924454 @default.
• W4323315259 cites W2059642778 @default.
• W4323315259 cites W2084632339 @default.
• W4323315259 cites W2096623507 @default.
• W4323315259 cites W2108535907 @default.
• W4323315259 cites W2134309588 @default.
• W4323315259 cites W2138121862 @default.
• W4323315259 cites W2138669624 @default.
• W4323315259 cites W2152407075 @default.
• W4323315259 cites W2168479321 @default.
• W4323315259 cites W2171355272 @default.
• W4323315259 cites W2349230331 @default.
• W4323315259 cites W2406454118 @default.
• W4323315259 cites W2528037656 @default.
• W4323315259 cites W2742254242 @default.
• W4323315259 cites W2743010525 @default.
• W4323315259 cites W2757117686 @default.
• W4323315259 cites W2759305519 @default.
• W4323315259 cites W2788271038 @default.
• W4323315259 cites W2981104420 @default.
• W4323315259 cites W2981500142 @default.
• W4323315259 cites W3044402202 @default.
• W4323315259 cites W3153091537 @default.
• W4323315259 cites W3167301104 @default.
• W4323315259 cites W4210891390 @default.
• W4323315259 doi "https://doi.org/10.1002/osi2.1179" @default.
• W4323315259 hasPublicationYear "2023" @default.
• W4323315259 type Work @default.
• W4323315259 citedByCount "0" @default.
• W4323315259 crossrefType "journal-article" @default.
• W4323315259 hasAuthorship W4323315259A5018988574 @default.
• W4323315259 hasAuthorship W4323315259A5020773105 @default.
• W4323315259 hasAuthorship W4323315259A5039224202 @default.
• W4323315259 hasAuthorship W4323315259A5045348619 @default.
• W4323315259 hasAuthorship W4323315259A5059829379 @default.
• W4323315259 hasAuthorship W4323315259A5060319614 @default.
• W4323315259 hasAuthorship W4323315259A5064977104 @default.
• W4323315259 hasAuthorship W4323315259A5074919615 @default.
• W4323315259 hasConcept C134018914 @default.
• W4323315259 hasConcept C139770010 @default.
• W4323315259 hasConcept C1491633281 @default.
• W4323315259 hasConcept C170493617 @default.
• W4323315259 hasConcept C185592680 @default.
• W4323315259 hasConcept C2776362946 @default.
• W4323315259 hasConcept C2777506169 @default.
• W4323315259 hasConcept C2779438470 @default.
• W4323315259 hasConcept C2780323712 @default.
• W4323315259 hasConcept C502942594 @default.
• W4323315259 hasConcept C54355233 @default.
• W4323315259 hasConcept C55493867 @default.
• W4323315259 hasConcept C555293320 @default.
• W4323315259 hasConcept C62112901 @default.
• W4323315259 hasConcept C79879829 @default.
• W4323315259 hasConcept C81885089 @default.
• W4323315259 hasConcept C86803240 @default.
• W4323315259 hasConcept C98274493 @default.
• W4323315259 hasConceptScore W4323315259C134018914 @default.
• W4323315259 hasConceptScore W4323315259C139770010 @default.
• W4323315259 hasConceptScore W4323315259C1491633281 @default.
• W4323315259 hasConceptScore W4323315259C170493617 @default.
• W4323315259 hasConceptScore W4323315259C185592680 @default.
• W4323315259 hasConceptScore W4323315259C2776362946 @default.
• W4323315259 hasConceptScore W4323315259C2777506169 @default.
• W4323315259 hasConceptScore W4323315259C2779438470 @default.
• W4323315259 hasConceptScore W4323315259C2780323712 @default.
• W4323315259 hasConceptScore W4323315259C502942594 @default.
• W4323315259 hasConceptScore W4323315259C54355233 @default.
• W4323315259 hasConceptScore W4323315259C55493867 @default.
• W4323315259 hasConceptScore W4323315259C555293320 @default.
• W4323315259 hasConceptScore W4323315259C62112901 @default.
• W4323315259 hasConceptScore W4323315259C79879829 @default.
• W4323315259 hasConceptScore W4323315259C81885089 @default.
• W4323315259 hasConceptScore W4323315259C86803240 @default.

• next