FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323318277> ?p ?o ?g. }

• W4323318277 endingPage "4953" @default.
• W4323318277 startingPage "4953" @default.
• W4323318277 abstract "Bone loss occurs in astronauts during long-term space flight, but the mechanisms are still unclear. We previously showed that advanced glycation end products (AGEs) were involved in microgravity-induced osteoporosis. Here, we investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss by using the AGEs formation inhibitor, irbesartan. To achieve this objective, we used a tail-suspended (TS) rat model to simulate microgravity and treated the TS rats with 50 mg/kg/day irbesartan, as well as the fluorochrome biomarkers injected into rats to label dynamic bone formation. To assess the accumulation of AGEs, pentosidine (PEN), non-enzymatic cross-links (NE−xLR), and fluorescent AGEs (fAGEs) were identified in the bone; 8-hydroxydeoxyguanosine (8-OHdG) was analyzed for the reactive oxygen species (ROS) level in the bone. Meanwhile, bone mechanical properties, bone microstructure, and dynamic bone histomorphometry were tested for bone quality assessment, and Osterix and TRAP were immunofluorescences stained for the activities of osteoblastic and osteoclastic cells. Results showed AGEs increased significantly and 8-OHdG expression in bone showed an upward trend in TS rat hindlimbs. The bone quality (bone microstructure and mechanical properties) and bone formation process (dynamic bone formation and osteoblastic cells activities) were inhibited after tail-suspension, and showed a correlation with AGEs, suggesting the elevated AGEs contributed to the disused bone loss. After being treated with irbesartan, the increased AGEs and 8-OHdG expression were significantly inhibited, suggesting irbesartan may reduce ROS to inhibit dicarbonyl compounds, thus suppressing AGEs production after tail-suspension. The inhibition of AGEs can partially alter the bone remodeling process and improve bone quality. Both AGEs accumulation and bone alterations almost occurred in trabecular bone but not in cortical bone, suggesting AGEs effects on bone remodeling under microgravity are dependent on the biological milieu." @default.
• W4323318277 created "2023-03-07" @default.
• W4323318277 creator A5022754708 @default.
• W4323318277 creator A5030946510 @default.
• W4323318277 creator A5058794879 @default.
• W4323318277 creator A5071535731 @default.
• W4323318277 creator A5071919719 @default.
• W4323318277 creator A5073972923 @default.
• W4323318277 creator A5086914328 @default.
• W4323318277 creator A5087202209 @default.
• W4323318277 date "2023-03-03" @default.
• W4323318277 modified "2023-10-14" @default.
• W4323318277 title "Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products" @default.
• W4323318277 cites W1888774673 @default.
• W4323318277 cites W1966136179 @default.
• W4323318277 cites W1970479919 @default.
• W4323318277 cites W1971589882 @default.
• W4323318277 cites W1977489392 @default.
• W4323318277 cites W1983341185 @default.
• W4323318277 cites W1985260952 @default.
• W4323318277 cites W1988102983 @default.
• W4323318277 cites W1994647035 @default.
• W4323318277 cites W2010370140 @default.
• W4323318277 cites W2014092961 @default.
• W4323318277 cites W2022836308 @default.
• W4323318277 cites W2037786457 @default.
• W4323318277 cites W2050614637 @default.
• W4323318277 cites W2053679002 @default.
• W4323318277 cites W2054680082 @default.
• W4323318277 cites W2058375582 @default.
• W4323318277 cites W2060678541 @default.
• W4323318277 cites W2062095138 @default.
• W4323318277 cites W2075877355 @default.
• W4323318277 cites W2083991002 @default.
• W4323318277 cites W2086732436 @default.
• W4323318277 cites W2086933933 @default.
• W4323318277 cites W2088588903 @default.
• W4323318277 cites W2116458615 @default.
• W4323318277 cites W2118532242 @default.
• W4323318277 cites W2118734820 @default.
• W4323318277 cites W2136497849 @default.
• W4323318277 cites W2152136687 @default.
• W4323318277 cites W2152196075 @default.
• W4323318277 cites W2156365988 @default.
• W4323318277 cites W2158621112 @default.
• W4323318277 cites W2162212747 @default.
• W4323318277 cites W2166435534 @default.
• W4323318277 cites W2199224494 @default.
• W4323318277 cites W2255019493 @default.
• W4323318277 cites W2328302466 @default.
• W4323318277 cites W2329659082 @default.
• W4323318277 cites W2346226609 @default.
• W4323318277 cites W2414866503 @default.
• W4323318277 cites W2422495554 @default.
• W4323318277 cites W2490352529 @default.
• W4323318277 cites W2575486971 @default.
• W4323318277 cites W2606348538 @default.
• W4323318277 cites W267679572 @default.
• W4323318277 cites W27166413 @default.
• W4323318277 cites W2757147362 @default.
• W4323318277 cites W2784587353 @default.
• W4323318277 cites W2799829761 @default.
• W4323318277 cites W2883984970 @default.
• W4323318277 cites W2888025177 @default.
• W4323318277 cites W2897281001 @default.
• W4323318277 cites W2921427704 @default.
• W4323318277 cites W2942311836 @default.
• W4323318277 cites W2952180399 @default.
• W4323318277 cites W2965949505 @default.
• W4323318277 cites W3048813625 @default.
• W4323318277 cites W3215980635 @default.
• W4323318277 cites W4200022802 @default.
• W4323318277 cites W4283732816 @default.
• W4323318277 cites W4308492580 @default.
• W4323318277 cites W4321350608 @default.
• W4323318277 cites W90529267 @default.
• W4323318277 doi "https://doi.org/10.3390/ijms24054953" @default.
• W4323318277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36902384" @default.
• W4323318277 hasPublicationYear "2023" @default.
• W4323318277 type Work @default.
• W4323318277 citedByCount "2" @default.
• W4323318277 countsByYear W43233182772023 @default.
• W4323318277 crossrefType "journal-article" @default.
• W4323318277 hasAuthorship W4323318277A5022754708 @default.
• W4323318277 hasAuthorship W4323318277A5030946510 @default.
• W4323318277 hasAuthorship W4323318277A5058794879 @default.
• W4323318277 hasAuthorship W4323318277A5071535731 @default.
• W4323318277 hasAuthorship W4323318277A5071919719 @default.
• W4323318277 hasAuthorship W4323318277A5073972923 @default.
• W4323318277 hasAuthorship W4323318277A5086914328 @default.
• W4323318277 hasAuthorship W4323318277A5087202209 @default.
• W4323318277 hasBestOaLocation W43233182771 @default.
• W4323318277 hasConcept C126322002 @default.
• W4323318277 hasConcept C134018914 @default.
• W4323318277 hasConcept C147990577 @default.
• W4323318277 hasConcept C170033053 @default.
• W4323318277 hasConcept C170493617 @default.
• W4323318277 hasConcept C185592680 @default.

• next