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- W4323319944 abstract "The Yangyuan donkey is a domestic animal breed mainly distributed in the northwest region of Hebei Province. Donkey body shape is the most direct production index, can fully reflect the donkey’s growth status, and is closely related to important economic traits. As one of the main breeding selection criteria, body size traits have been widely used to monitor animal growth and evaluate the selection response. Molecular markers genetically linked to body size traits have the potential to accelerate the breeding process of animals via marker-assisted selection. However, the molecular markers of body size in Yangyuan donkeys have yet to be explored. In this study, we performed a genome-wide association study to identify the genomic variations associated with body size traits in a population of 120 Yangyuan donkeys. We screened 16 single nucleotide polymorphisms that were significantly associated with body size traits. Some genes distributed around these significant SNPs were considered candidates for body size traits, including SMPD4 , RPS6KA6 , LPAR4 , GLP2R , BRWD3 , MAGT1 , ZDHHC15 , and CYSLTR1 . Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that these genes were mainly involved in the P13K-Akt signaling pathway, Rap1 signaling pathway, regulation of actin cytoskeleton, calcium signaling pathway, phospholipase D signaling pathway, and neuroactive ligand-receptor interactions. Collectively, our study reported on a list of novel markers and candidate genes associated with body size traits in donkeys, providing useful information for functional gene studies and offering great potential for accelerating Yangyuan donkey breeding." @default.
- W4323319944 created "2023-03-07" @default.
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- W4323319944 date "2023-02-28" @default.
- W4323319944 modified "2023-09-30" @default.
- W4323319944 title "Genome-wide association study to identify SNPs and candidate genes associated with body size traits in donkeys" @default.
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- W4323319944 doi "https://doi.org/10.3389/fgene.2023.1112377" @default.
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