Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323320182> ?p ?o ?g. }
- W4323320182 abstract "We examined the immune response in subjects previously infected with SARS-CoV2 and infection-naïve 9 months after primary 2-dose COVID-19 mRNA vaccination and 3 months after the booster dose in a longitudinal cohort of healthcare workers. Nine months after primary vaccination, previously infected subjects exhibited higher residual antibody levels, with significant neutralizing activity against distinct variants compared to infection-naïve subjects. The higher humoral response was associated with higher levels of receptor binding domain (RBD)-specific IgG + and IgA + memory B cells. The booster dose increased neither neutralizing activity, nor the B and T cell frequencies. Conversely, infection-naïve subjects needed the booster to achieve comparable levels of neutralizing antibodies as those found in previously infected subjects after primary vaccination. The neutralizing titer correlated with anti-RBD IFNγ producing T cells, in the face of sustained B cell response. Notably, pre-pandemic samples showed high Omicron cross-reactivity. These data show the importance of the booster dose in reinforcing immunological memory and increasing circulating antibodies in infection-naïve subjects." @default.
- W4323320182 created "2023-03-07" @default.
- W4323320182 creator A5007332525 @default.
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- W4323320182 creator A5046398268 @default.
- W4323320182 creator A5071305673 @default.
- W4323320182 creator A5071836029 @default.
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- W4323320182 creator A5078511492 @default.
- W4323320182 creator A5090115261 @default.
- W4323320182 creator A5090926666 @default.
- W4323320182 date "2023-02-28" @default.
- W4323320182 modified "2023-09-26" @default.
- W4323320182 title "Long-term adaptive response in COVID-19 vaccine recipients and the effect of a booster dose" @default.
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