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- W4323322249 endingPage "104516" @default.
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- W4323322249 abstract "Control of microvascular reactivity by 5-hydroxytryptamine (5-HT; serotonin) is complex and may depend on vascular bed type and 5-HT receptors. 5-HT receptors consist of seven families (5-HT1-5-HT7), with 5-HT2 predominantly mediating renal vasoconstriction. Cyclooxygenase (COX) and smooth muscle intracellular Ca2+ levels ([Ca2+]i) have been implicated in 5-HT-induced vascular reactivity. Although 5-HT receptor expression and circulating 5-HT levels are known to be dependent on postnatal age, control of neonatal renal microvascular function by 5-HT is unclear. In the present study, we demonstrate that 5-HT stimulated human TRPV4 transiently expressed in Chinese hamster ovary cells. 5-HT2A is the predominant 5-HT2 receptor subtype in freshly isolated neonatal pig renal microvascular smooth muscle cells (SMCs). HC-067047 (HC), a selective TRPV4 blocker, attenuated cation currents induced by 5-HT in the SMCs. HC also inhibited the 5-HT-induced increase in renal microvascular [Ca2+]i and constriction. Intrarenal artery infusion of 5-HT had minimal effects on systemic hemodynamics but reduced renal blood flow (RBF) and increased renal vascular resistance (RVR) in the pigs. Transdermal measurement of glomerular filtration rate (GFR) indicated that kidney infusion of 5-HT reduced GFR. HC and 5-HT2 receptor antagonist ritanserin attenuated 5-HT effects on RBF, RVR, and GFR. Moreover, the serum and urinary COX-1 and COX-2 levels in 5-HT-treated piglets were unchanged compared with the control. These data suggest that activation of renal microvascular SMC TRPV4 channels by 5-HT impairs kidney function in neonatal pigs independently of COX production." @default.
- W4323322249 created "2023-03-07" @default.
- W4323322249 creator A5015648894 @default.
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- W4323322249 creator A5051636676 @default.
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- W4323322249 creator A5089800747 @default.
- W4323322249 date "2023-07-01" @default.
- W4323322249 modified "2023-10-17" @default.
- W4323322249 title "Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs" @default.
- W4323322249 cites W1562867663 @default.
- W4323322249 cites W1576483067 @default.
- W4323322249 cites W1747865589 @default.
- W4323322249 cites W1809659791 @default.
- W4323322249 cites W1947953470 @default.
- W4323322249 cites W1963504386 @default.
- W4323322249 cites W1972695142 @default.
- W4323322249 cites W1974062150 @default.
- W4323322249 cites W1979411920 @default.
- W4323322249 cites W1979898627 @default.
- W4323322249 cites W1980424296 @default.
- W4323322249 cites W1984362583 @default.
- W4323322249 cites W1992233475 @default.
- W4323322249 cites W1992586456 @default.
- W4323322249 cites W1996196123 @default.
- W4323322249 cites W1997389205 @default.
- W4323322249 cites W1997673753 @default.
- W4323322249 cites W2001518596 @default.
- W4323322249 cites W2008234296 @default.
- W4323322249 cites W2008673308 @default.
- W4323322249 cites W2014412928 @default.
- W4323322249 cites W2016722110 @default.
- W4323322249 cites W2016763515 @default.
- W4323322249 cites W2024162635 @default.
- W4323322249 cites W2025840607 @default.
- W4323322249 cites W2027265533 @default.
- W4323322249 cites W2029766879 @default.
- W4323322249 cites W2031510041 @default.
- W4323322249 cites W2041783474 @default.
- W4323322249 cites W2044178972 @default.
- W4323322249 cites W2051301065 @default.
- W4323322249 cites W2055776948 @default.
- W4323322249 cites W2072674617 @default.
- W4323322249 cites W2072964410 @default.
- W4323322249 cites W2076375792 @default.
- W4323322249 cites W2077005607 @default.
- W4323322249 cites W2078426939 @default.
- W4323322249 cites W2079770562 @default.
- W4323322249 cites W2084954290 @default.
- W4323322249 cites W2085683781 @default.
- W4323322249 cites W2087301325 @default.
- W4323322249 cites W2087777477 @default.
- W4323322249 cites W2093586784 @default.
- W4323322249 cites W2096028417 @default.
- W4323322249 cites W2096222016 @default.
- W4323322249 cites W2098697701 @default.
- W4323322249 cites W2112789217 @default.
- W4323322249 cites W2114532320 @default.
- W4323322249 cites W2115355276 @default.
- W4323322249 cites W2117107897 @default.
- W4323322249 cites W2119243552 @default.
- W4323322249 cites W2119749069 @default.
- W4323322249 cites W2123730244 @default.
- W4323322249 cites W2124136032 @default.
- W4323322249 cites W2135190897 @default.
- W4323322249 cites W2137006447 @default.
- W4323322249 cites W2141004359 @default.
- W4323322249 cites W2145491618 @default.
- W4323322249 cites W2145508054 @default.
- W4323322249 cites W2145596097 @default.
- W4323322249 cites W2147529770 @default.
- W4323322249 cites W2148761780 @default.
- W4323322249 cites W2153853866 @default.
- W4323322249 cites W2156339806 @default.
- W4323322249 cites W2156930797 @default.
- W4323322249 cites W2157432035 @default.
- W4323322249 cites W2168502120 @default.
- W4323322249 cites W2198960616 @default.
- W4323322249 cites W2199728488 @default.
- W4323322249 cites W2215021607 @default.
- W4323322249 cites W2278203622 @default.
- W4323322249 cites W2306327748 @default.
- W4323322249 cites W2312442452 @default.
- W4323322249 cites W2385174333 @default.
- W4323322249 cites W2407233660 @default.
- W4323322249 cites W2407597967 @default.
- W4323322249 cites W2410559368 @default.
- W4323322249 cites W2411146613 @default.
- W4323322249 cites W2412543202 @default.
- W4323322249 cites W2423462835 @default.
- W4323322249 cites W2441348615 @default.
- W4323322249 cites W2444664364 @default.
- W4323322249 cites W2461494530 @default.
- W4323322249 cites W2468805370 @default.
- W4323322249 cites W2512492485 @default.
- W4323322249 cites W2537612038 @default.